BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
Fagniez et al identify new patients w/ inherited RORγT deficiency characterized by impaired TCRα rearrangement, depletion of MAIT & iNKT cells, reduced numbers of TH17, TH1* & CD8+ T cells, & defective IFN-γ & IL-17 immunity against Mycobacterium & Candida https://t.co/rfCtTJvd0x
Our understanding of the innate immune mechanisms related tuberculosis (TB) is limited. New data suggest that neutrophil subpopulations are associated with TB disease progression as they can modulate CD8 T cells’ functions. Learn more in The JI: https://t.co/vqkYswasRF.
Airway immune signatures of protection and disease progression in recent human tuberculosis household contacts | Nature Immunology https://t.co/f2FtcmoISr
Type I IFN drives #neutrophil swarming, impeding lung T cell–#macrophage interactions and #TB control. From William Branchett, Anne O’Garra et al. https://t.co/cK2OR6pQWd
📘 Updates on the Immune Responses to #Tuberculosis and #HIV: https://t.co/Ks0q62yTzP
#KSTB26#KSHIVVax26
So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. https://t.co/vbdpLKjQCa
The January 2026 issue of Science #Immunology is out!
This month's cover depicts the repopulation of resident cardiac #macrophages after #chemotherapy, protecting the heart against subsequent injury. Learn about this research and more: https://t.co/OBN7jA473N
Our October issue is here! https://t.co/H9LZ4SFHB2
The cover image shows the lung of a mouse infected with M. #tuberculosis stained for #neutrophils (orange) normal lung parenchyma (blue), collagen (white) and CD4 T cells (green). See Gern et al. https://t.co/Prz4AK8kAt
BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
Happy to share our recent paper in @eLife showing the detrimental effects of β-Glucan in a murine LPS-model of lung injury This study was led by Renaud from @chubordeauxfr and incredible collaborators @erwan_pernet@kimaimytran Dr Poschmann @NantesUniv https://t.co/HoNP7F9PIt
New research in Science supports the idea that adult neurogenesis occurs in the human hippocampus, which has been one of the most debated issues in neuroscience.
Learn more: https://t.co/6UUjSTWKuZ
A June #TopRead identified different subtypes of neutrophils in #tuberculosis (TB) patients, indicating that neutrophils might be promising targets for TB host-directed therapy. Learn more: https://t.co/o5qBSdDrC8.
A new @NIAIDNews study cautions against the use of PD-1 checkpoint blockade #immunotherapy as a treatment for #tuberculosis, revealing that the treatment increased bacterial loads and worsened chronic disease in rhesus macaques: https://t.co/aOXKzTSA9I @SciImmunology
Higher levels of natural killer cells are associated with tuberculosis latency, reports a paper published in Nature. The findings raise the question as to whether natural killer cells might play an active role in controlling tuberculosis infections https://t.co/uU2s02JRfI
#Neutrophils can exhibit substantial function diversity. Montaldo et al @OstuniLab perform immunophenotyping and transcriptome analysis to characterize the heterogeneity of human neutrophils, both under steady state and upon stress-induced conditions. https://t.co/qkOEUsekxJ