Daniel Barber, PhD

Immunologist at the NIH/NIAID/Intramural Research Program.

[Mihalis Lionakis @LionakisLab]

In @elife: Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency https://t.co/TWcliQTSlG

[Daniel Barber, PhD @danielleobarber]

@RobertPRousseau Thanks Rob!

[Daniel Barber, PhD @danielleobarber]

So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. https://t.co/vbdpLKjQCa

[Daniel Barber, PhD @danielleobarber]

@yufanzheng7 @LabWaggoner Thanks Ivan!

[Daniel Barber, PhD @danielleobarber]

@Sutherland_TB @mayer_barber Thanks Jayne!

[Daniel Barber, PhD @danielleobarber]

@fyarovinsky Thanks Felix!

[Daniel Barber, PhD @danielleobarber]

@javid_lab @mayer_barber Thanks Babak! This one took a while, lol.

[Daniel Barber, PhD @danielleobarber]

@MazDivangahi Thanks Maz!

[Daniel Barber, PhD @danielleobarber]

We still don’t understand how T cells control tuberculosis. Our new paper shows that Mtb-specific T cells in NHP and human lung granulomas make many interesting effector molecules upon TCR stimulation. There’s a whole lot more to T cells in TB than IFNγ!

https://t.co/30hEKjFnnu

[Daniel Barber, PhD @danielleobarber]

We are looking to hire post-docs to work on T cell responses to M. tuberculosis infection using murine and NHP models. If you know T cells and wanna work on the top infectious killer check us out. The NIH intramural program is an amazing place!

[Daniel Barber, PhD @danielleobarber]

We are looking for post-docs! If you are interested in T cell responses to M. tuberculosis infection check us out. The NIH Intramural program is a great place to train!

[joanne flynn @joanneflynn19]

Happy to share https://t.co/GlMBJdKgml @CellPress Immunity. CD4 T cells contribute to protection against #TB in a reinfection macaque model by interacting with CD8s to generate an anti-inflammatory granuloma environment. Kudos to first authors Sharie Ganchua and @joshuabromley21

[Immunology of Infectious Disease News @infdisease_news]

Scientists at @NIAIDNews examined the roles of the prototypic pro- and anti-🌡️ #inflammatory cytokines IFNγ and IL-10 using the rhesus macaque model of mild #COVID19.

👇 Check out their discovery on the role of IFNγ in lung lesions.

@PLOSPathogens | https://t.co/ezoR1aDin0

[Daniel Barber, PhD @danielleobarber]

We are looking for a technician to join our team working on immune responses to tuberculosis in NHP models. The NIH is a super fun place to do research. Have a look! https://t.co/a3JjeFKNXO

[Daniel Barber, PhD @danielleobarber]

Incredible study from @LionakisLab !!!

[Mihalis Lionakis @LionakisLab]

1/n Proud to share our latest work @NEJM. A long journey of integrated basic research and clinical care revealed a central role for IFN-g in driving mulitorgan autoimmunity in APECED and devised a personalized, life-transformative intervention for patients
https://t.co/cvV2D7LP9f

[Daniel Barber, PhD @danielleobarber]

@Tcellogic This is amazing!! Congrats Sue!!

[Daniel Barber, PhD @danielleobarber]

Check out the new paper from Kat Mayer-Barber’s lab. Heterogeneity in outcomes of SARS-CoV-2 may be in part due to the recent pulmonary immune history of the host.

[Journal of Experimental Medicine @JExpMed]

Next article in the lead up to #WorldTBDay 🫁 on March 24: @TaylorForeman19, @danielleobarber et al. show that, in mice, CD30 drives T cell differentiation and is required for host survival of Mycobacterium #tuberculosis infection ➡️ https://t.co/2mwKvUdlEx
#endTB

[Daniel Barber, PhD @danielleobarber]

We are looking for post-docs interested in studying T cell responses to M. tuberculosis infection. The NIH intramural program is an amazing place to train! Check us out.