Vignali and colleagues report CD8+ T cells in the pancreatic islets have a LAG3-promoted ‘restrained’ phenotype resembling exhausted cells but maintain effector functions, and LAG3 expression limits pathology in the NOD mouse model of type 1 diabetes https://t.co/4V4lzC6xqc
Autoreactive intra-islet CD8+ T cells look exhausted (pheno/RNA/epige/meta), yet can be perturbed from their restrained state by ablation of LAG3. Thus, LAG3 limits autoimmunity and is a therapeutic target. @Vignali_Lab@StephGrebinoski QianxiaZhang
https://t.co/IDTfUDiqwG