Catherine Phelps

Candidate in the @MeiselLab at University of Pittsburgh @Pitt_PMI 🏃‍♀️🛼👩‍🔬

[Catherine Phelps @CatMPhelps]

I am BEYOND excited to share my PhD thesis research is officially published in @CellCellPress today.

Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃‍♀️🦠

https://t.co/Opgn2OEFXL

[Bernard A Fox @BernardAFox]

Catherine Phelps from @upmc.com representing #SITC Talks on how #exercise can improve outcome - role for #microbial #metabolite #formate on mediating #anticancer #immunity / #WIC2025 #SITC2025

[Aaron Yang @aaron_null_yang]

Talking about 3D chromatin and T cell exhaustion at #TRCCC2024

[Marisol Soengas @msmelanoma]

Yet another reason to exercise!
Phelps et al.
https://t.co/h5oxHWlvKg

[Capybaras @CapybaraCountry]

It’s dangerous to go alone! Take this!

[Capybaras @CapybaraCountry]

Anyway, here’s Wonderwall

[Capybaras @CapybaraCountry]

He’s on vacation

[Immunity @ImmunityCP]

Online now: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity https://t.co/YjaFCnUizG

[Waggoner Lab @LabWaggoner]

Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity @ImmunityCP @surya25_pandey @YinanGong @RH_Laboratory
https://t.co/dJSwo1mgEo

[nature @Nature]

A potent bacterium in the human gut can supercharge the effects of some cancer drugs

https://t.co/149U85Qz90

[Ivan Zanoni @Lo_Zanzi]

#MicrobiotaPower & #Exercise! Phelps, Meisel &co show @CellCellPress that exercise drives formate from microbiota that in turns activates NRF2 in CD8 T cells driving STAT1/IRF8 programs that potentiate immune checkpoint inhibitor efficacy against melanoma https://t.co/ZyfnjuYjae

[The American Association of Immunologists (AAI) @ImmunologyAAI]

AAI Members in the News! For her graduate thesis with Dr. Marlies Meisel at @Pitt_Medicine, @CatMPhelps found that #exercise improved #cancer outcomes and enhanced responses to #immunotherapy in mice by reshaping the gut #microbiome. Congrats!

🔗 https://t.co/qxmCkOHWHw

[Emre Yekedüz @yekeduz_emre]

🏃‍♂️💥 Exercise boosts immunotherapy!
New study shows exercise increases gut microbiota-derived formate, enhancing CD8+ T cell–mediated antitumor immunity via Nrf2.
⭐️Formate may be a new biomarker for better ICI response in melanoma.

@CellPressNews @OncoAlert #microbiome #cancer #Oncology

https://t.co/LRUbRjP67n

[Dr. Patrick Hwu @PatrickHwuMD]

#ScienceSaturday

🏃‍♂️🧬 Can exercise really help fight #cancer?

📢 A new study in @CellCellPress shows exercise rewires the gut #microbiome to enhance immune responses against tumors.

➡️ @CatMPhelps et al. found exercise increases levels of a microbiota-derived metabolite called formate, which boosts CD8 T cell function through the Nrf2 pathway. This strengthens the immune system’s ability to attack tumors, even those resistant to immune checkpoint inhibitors.

➡️ In #melanoma models, both exercise and formate supplementation reduced tumor growth, increased survival and amplified the effects of immunotherapy. High-formate-producing human microbiota showed similar antitumor effects in preclinical studies.

💡 These findings suggest a powerful link between movement, metabolism, and immune activation.

🔗 Read the full article in Cell: https://t.co/olgbAwgyiK

@PittTweet @Pitt_PMI

[Neil Renic @NC_Renic]

True academic friendship is agreeing to sit in the audience for their 8:15am presentation

[Dr Meming @Dr_Meming]

Me right before a deadline

[nature @Nature]

Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate

https://t.co/AXAslrvINt

[exploreVenango @exploreVenango]

New University of Pittsburgh research shows gut bacteria are responsible for how exercise boosts cancer treatment in mice, pointing to possible future therapies for humans.
https://t.co/Rytd1gvL5w

[Catherine Phelps @CatMPhelps]

Nice thread showing highlights of our study:

[Samuel Hume @DrSamuelBHume]

Why is exercise anti-cancer?

Mice that exercise suppress tumors better than those that don't

If those mice are treated with antibiotics, the gut microbiome is depleted and the effect is pretty much gone: it's (at least partly) mediated by gut bacteria

🧵

[Oncology Tube @oncologytube]

🔥HOT 2025 DISCOVERY! Original post @EricTopol https://t.co/Tr9ewsQ8PN July 2025
💪Exercise could SAVE lives by supercharging melanoma immunotherapy via gut microbiome!
🪂Dive into our MUST-SEE Exclusive Video
Link: https://t.co/tuWO56nlCp

#MelanomaHope #ExerciseRevolution #GutPower

@CellCellPress @sumersethi @hkanji @vankapro @kidsgastrodoc @mairal @DrSunitKSingh @Prof_NickTalley @DrRobertGlatter @MatCMeier @renesugar @SchezBorrego @P1231032850 @Bosphiz @DrJohanLim @RoryEvergrowth @CreativoEnfocad @MaggyLizaola @anaiscamacho @cinthiavgauna @HendryVictoria @xixedhellonja @NovateurBio @giorg_kyriakos @nuuuukkkkk @OscarTahuahua @cihan390 @FloraFromDaRock @ForYetBetterSci @leonardopviana @EdAlvarezB @SaubashyaSur @CrypvizerGolin @HTX_Cisco @EduardoSuarez25 @LorenaShaw @JasmineSukumar @Vic_Bioinfo @UofLEnvirome @vhugo8762 @MatSaubade @DanijelaGasevic @MPH_Stone @wot_mikey @gnomikos1 @Shell_Bell1957 @PittDeptofMed @CatMPhelps

[exploreClarion @exploreclarion]

New University of Pittsburgh research shows gut bacteria are responsible for how exercise boosts cancer treatment in mice, pointing to possible future therapies for humans.
https://t.co/Eo42WZdqg2