xsfear

Sustainable Accelerationist for Human Flourishing, Decentralized IoAI, Ancient Wisdom, Creativity & Curiosity Resonator

[Avi Roy @agingroy]

Right now, the sugar in your blood is sticking to your proteins. Not the sugar from food, but the glucose every cell runs on. Your HbA1c test measures this: sugar attached to a blood protein. Blood renews every few months, so that clears out. But your collagen, eye lenses, and artery walls last for decades, and there the sugar builds up into deposits called AGEs that stiffen the tissue. For 40 years, this was considered permanent, and no diet could reverse it.

Today, a paper reversed that view. Revel Pharmaceuticals, spun out of @DASpiegel256's Yale lab, engineered an enzyme that finds one of these tags, CML, and rebuilds the original protein. In tissue from elderly donors, it cleared over 70% from aged arteries and brought 75-year-old skin below a 31-year-old's level. The brown staining in the image is that damage. The pale panel is the same-aged tissue after the enzyme.

There are several caveats. It's in a dish, not a living body. It clears CML, not glucosepane, the crosslink that stiffens tissue most and is still beyond reach. Whether it works in a living person, nobody knows yet.

But "irreversible" just cracked. Revel is an @aubreydegrey spinout, the repair thesis he's pushed for 25 years, finally on the board.

[Nicolas Hulscher, MPH @NicHulscher]

A new study found eating 2 kiwis a day increased skin density by 48% and epidermal cell regeneration by 30% in just 8 weeks.

Vitamin C levels significantly increased in the blood, skin fluid, and epidermal tissue—improving overall skin structure from the inside out.

[Bryan Johnson @bryan_johnson]

This is great news.

As you age, sugar binding to your proteins creates stiff, sticky chemical scars that affect skin, arteries, eyes and more. It was considered irreversible and now may be reversible, restoring to a healthy state.

Researches did this by using AlphaFold to search 45,000 oxidases, then screened more than 500 million engineered variants through directed evolution.

The work is still ex vivo in a lab setting. Delivering a large bacterial enzyme safely into living tissues, with sufficient penetration and bioavailability, remains a major challenge.

[xsfear @SteveFearnow]

HUMAN Stem Cells Have Reversed Age In Monkey's with ZERO Side Effects https://t.co/ejF389kp6q via @YouTube

[xsfear @SteveFearnow]

Arthritis Cure BREAKTHROUGH: Regrow Young Cartilage https://t.co/lIAB6inmmT via @YouTube

[The Husky @Mr_Husky1]

In 1940, a pair of identical twin boys were born in Ohio and placed for adoption just weeks after birth. They were sent to different families who had no contact with each other. Neither family knew much about the other. Each set of parents, independently, chose to name their new son James.
The two boys grew up in separate homes, in separate towns, living what appeared to be entirely separate lives. But as researchers would later discover, the parallels running through those lives were almost impossible to believe.
Both boys went by the nickname Jim. Both married a woman named Linda, then divorced her. Both then remarried a woman named Betty. Both had a son and named him James Alan. Both owned a dog at some point in their childhood and gave it the same name: Toy. Both had worked in law enforcement. Both drove the same model of Chevrolet. Both had built a white bench around a tree in their backyard.
Neither Jim knew the other existed until 1979, when they were 39 years old and finally reunited.
The case of James Springer and James Lewis, known ever since as the Jim Twins, became one of the most studied examples in the history of twin research. University of Minnesota researchers used their reunion as a landmark moment in understanding how much of human personality, preference, and behavior is shaped by genetics rather than environment.
Two men raised by strangers in different towns. Same name. Same marriages. Same dog. Same sons. Same bench in the backyard.
Some things, it turns out, run deeper than circumstance.

[xsfear @SteveFearnow]

@r0ck3t23 @davidicke 😂

[The Vigilant Fox 🦊 @VigilantFox]

Joe Rogan fell into stunned silence as Dr. Casey Means rattled off one disturbing health stat after another.

“We are getting destroyed, and it’s very recent, and it’s accelerating,” she warned.

• “74% of Americans are overweight or obese.”

• “Young adult cancers are going up 79% in the last 10 years.”

• “25% of men now under 40 have erectile dysfunction.”

• “50%, now, of American adults have type 2 diabetes or prediabetes. These were diseases where there was 1% of Americans in 1950 had type 2 diabetes. Now it’s 50% of Americans have prediabetes or type 2 diabetes.”

• “Alzheimer’s, dementia are going through the roof.”

• “Young adult dementias have increased, like, three times since 2012. So early onset dementias.”

• “One in two Americans are expected to have cancer in their lifetime now, one in two.”

• “One in [31] children has autism now, in the United States. That was one in 150 in the year 2000.”

• “In California, where I live, [Autism rates are] one in 22. One in 22 with a lifetime neurodevelopmental disorder.”

• “Infertility going up 1% per year.”

• “77% of young Americans can’t serve in the military because of obesity or drug abuse.”

• “Autoimmune diseases. Some studies are saying they’re going up 13% per year.”

• “Heart disease, which is almost totally preventable, is the leading cause of death in the United States, killing around 800,000 people per year.”

“It’s basically like all of us are a little bit dead while we’re alive,” Dr. Means said.

These aren’t unrelated crises. They share the same biological pattern — a body stuck in survival mode.

And once you understand what’s keeping your body there, the path to real healing finally makes sense. 🧵

[xsfear @SteveFearnow]

@bryan_johnson PLEASE WATCH. Hands down the most promising research backed by hundreds of top doctors but needs funding.

https://t.co/URVeyfyKrJ

[xsfear @SteveFearnow]

@bryan_johnson PLEASE WATCH. Hands down the most promising research backed by hundreds of top doctors but needs funding.

https://t.co/URVeyfyKrJ

[xsfear @SteveFearnow]

@joerogan @Spotify This guy NEEDS to be heard on bigger platforms. Established Top Scientists have backed his research and is looking for funding.

https://t.co/6eESlzRLBS

[xsfear @SteveFearnow]

@SecKennedy https://t.co/6eESlzRLBS

[xsfear @SteveFearnow]

The Cancer Code, Gene Reprogramming, & Searching for a Cure | Marc Malone https://t.co/mruB5fU3Mt via @YouTube

[Aesthetic Gentleman - Fitness | Fashion | Health @BAestheticMan]

If you continue to eat this way you’ll be layering pounds on your body.

[David Whitehead @TruthWarriorDad]

Did you know that The Lord of the Rings was about resisting communism? @Kristof_Poland

[ABC News @ABC]

JUST IN: After two people climbed to the top of the Empire State Building and unfurled a banner on top of its spire Wednesday afternoon, one of the climbers appeared to propose to the other. https://t.co/ngG3jOeTBU

[Elon Musk @elonmusk]

Exactly

[Krzysztof Szczawinski 🇵🇱 @Kristof_Poland]

Atlas Shrugged made simple:

1. Society runs on a small number of highly capable producers – industrialists, inventors, engineers – whose work everyone depends on but takes for granted.

2. The system starts rewarding need over achievement: the more capable you are, the more you’re expected to sacrifice for those who aren’t.

3. Success gets treated like a debt – taxed, regulated, resented – until the most capable start asking why they bother trying at all.

4. One by one, led by a man named John Galt, they simply withdraw – walking away rather than keep propping up a system that punishes them for producing.

5. Without them, the whole structure collapses, revealing that the “automatic” prosperity everyone assumed was actually being generated by specific, irreplaceable people.

6. Atlas is the Titan from Greek myth, condemned to carry the sky on his shoulders forever – Rand’s stand-in for the producer class, holding up civilization while getting blamed for it.

7. “Shrugged” is the whole argument in one word: Atlas doesn’t fight, doesn’t protest – he just quietly sets the weight down. Nobody realized the sky was being held up by anyone in particular, until the day it isn’t.
You don’t want us? We just go…🤷🏻‍♂️

[xsfear @SteveFearnow]

No. We hate OURSELVES more for not hating those we should hate because “they” know us better than we know ourselves. We have Parents Teachers Bosses Preachers who are all themselves followers. The mentors, guides, builders, and truth tellers have been under attack for centuries. Until modern life gets more uncomfortable people will never get mad enough to question what real freedom requires.

[Bryan Johnson @bryan_johnson]

On Saturday, my children and I would go to the local running and biking trail and hand out water and bars.

People were suspicious.

They'd ask "how much does it cost?" We'd say free. Then they'd ask what cause it was for. We'd say none. At this point they'd be stupefied. There must be a catch. There was no catch.

The suspicion is an appendage of a culture that prioritizes status and money. The more selfless the act looks, the harder they search for the hidden angle.

I was experimenting as a father how to teach virtue. The value of helping someone without agenda or the need to get something back.

There is science to this. It's called the overjustification effect. Give a toddler a reward for helping and afterward they help less. The reward replaces the instinct. By attaching a payoff to a good deed, you corrode the good deed.

Children are born with the instinct to help before anyone rewards them. By age two they are happier giving a treat away than receiving one, and happiest when the treat they give up is their own.

It also causes moral elevation. Watching someone help others lifts the people who are watching and makes them want to do so themselves.