Sytse Piersma

[The Journal of Immunology @J_Immunol]

Using an inducible genetic mouse model, researchers found that during ATP citrate lyase is required for upregulating glycolysis IL-15 priming, NK cell proliferation, cytotoxicity, and activating certain receptors. Read more: https://t.co/dNTwGhVH5l.

[The Journal of Immunology @J_Immunol]

In this #CuttingEdge article, researchers describe the pivotal role of uterine NK cells in pregnancy, offering novel insights into their lineage specification and revealing Eomesodermin as crucial to their establishment. Learn more: https://t.co/Q12lnswhZu

[Sytse Piersma @SytseP]

@JExpMed @sushantbangru @KalsotraLab @WUSTLmed Honored to be part of this collection!

[Sytse Piersma @SytseP]

@Husultan @washupathedu @NateraGenetics @parkerici Congrats Hussein, well deserved!

[Hussein Sultan @Husultan]

I am pleased to share with you that my paper has been accepted in Nature https://t.co/7A7sIq0mgy
This work would not have been possible without the guidance of an exceptional mentor, support of awesome lab members and collaborators. @washupathedu @NateraGenetics @parkerici

[Quirin Hammer @QuirinHammer]

Happy to share the final work from my post-doc with @MalmbergLab published in @CellStemCell today https://t.co/ZcC8Q32kts
extensive 15-post-🧵 below

[Waggoner Lab @LabWaggoner]

NK cell IFNγ induces resistance of tumors to NK cells by upregulating classical & non-classical MHC-I, where therapeutic combination of monalizumab/lirilumab/DX9 may fully restore the antitumor response across NK cell subsets @capslocked_me @CerwenkaLab
https://t.co/QGKwCHz23A

[Jenn Tran @Jenn__Tran]

I have waited for this moment my entire PhD for @LabWaggoner to tweet about my work!!

[Waggoner Lab @LabWaggoner]

Expression of Ly49A alone on a H-2Dd background restored missing-self target cell rejection, NK cell licensing, and NK cell KLRG1 expression, therefore a single inhibitory Ly49 receptor is sufficient to license NK cells @SytseP #Yokoyama
https://t.co/4ll9yeeDUv

[Waggoner Lab @LabWaggoner]

Cis-regulatory evolution of the recently expanded Ly49 gene family @NatureComms @twang5 @SytseP #Yokoyama @ChangxuFan
https://t.co/AfyA31lxDb

[Journal of Experimental Medicine @JExpMed]

NK cells were first described five decades ago and named in 1975. This brief Perspective from Lewis Lanier @UCSF highlights a timeline of a few selected advancements in NK cell biology in each decade. https://t.co/dqkr4UV5SP

🎥 See video summary: https://t.co/dsZY2CWTzN

[Changxu Fan @ChangxuFan]

In the mouse, I believe the most NK cell-specific gene is Ly49h. I found its enhancer! Read about my discovery of MAP8 here: https://t.co/O0n61CiX9f
Many thanks to @twang5, @SytseP , and Wayne Yokoyama for the tremendous support!

[Waggoner Lab @LabWaggoner]

CD8α status identifies human NK cell capacity for IL-15-induced proliferation and metabolism in a time-dependent fashion and exhibits a suppressive effect on NK cell activating receptors @jclinicalinvest @LabFehniger @CeliaCubitt
https://t.co/pKIsFP0d1E

[Waggoner Lab @LabWaggoner]

Cryopreservation protocols optimized for T cells kill ~75% of NK cells w/in 24 h of thaw due to leakage of GzmB from vesicles. This is prevented by IL15/IL-18 pretreatment to ⬆️antiapoptotic genes & deplete gzmB containing granules [Berjis & Sheppard]
https://t.co/ugBgc8VBO3

[Waggoner Lab @LabWaggoner]

Trans Antigen Signaling Receptors (TASR) as a new class of NK inhibitory ligands and discovered universal capacity forCD300a to protect allogeneic T cells from NK cells
https://t.co/SrG3m6Ma2Z

[Quirin Hammer @QuirinHammer]

In this article, we provide a brief perspective of the promise of allogeneic cell therapies against cancer. We consider rejection by the recipient as a central pitfall and discuss approaches to reduce this rejection by genetic engineering

https://t.co/gUSYeBN5jE

[Sytse Piersma @SytseP]

@LabWaggoner Thank you for sharing!

[Waggoner Lab @LabWaggoner]

Tissue-specific features of ILCs in antiviral defense
REVIEW by @SytseP
https://t.co/MVssc0BQ5O

[Sytse Piersma @SytseP]

Online now in Cellular and Molecular Immunology: my review on the role of ILCs in virus infection with a focus on tissue specific features. https://t.co/WNf8AEukO5

[Waggoner Lab @LabWaggoner]

ITAM-based receptors in NK cells @oaaguilar503
https://t.co/DPQlSdhPG0