Results from a Phase 2 trial showed that a lower-intensity treatment regimen may be highly effective in some subsets of patients with acute myeloid leukemia.
Learn more: https://t.co/IYwvmqaB7N @tapkadia#EndCancer
Our most recent update of CLAD+LDAC+Ven now published - almost 200 pts with ~3yr f/u ; CR rate 84% and 92% in TP53 wildtype. @alexbataller https://t.co/t7VBN447v9
Great presentation by @jenweiying summarizing the frontline data with Oral Dac Ven Revumenib in patients with newly diagnosed NPM1-m and KMT2a-r AML. #ASH2025@MDAndersonNews
Big thanks to Drs. David A. Sallman, @Tapkadia and @dremmasearle for an outstanding #ASH25#AML session—packed with practical insights for everyday clinical care.
📺 Catch the replay: https://t.co/iUApohITS3
Grateful for grant support from @JNJInnovMed, @kuraoncology and @Syndax, and for our collaboration with @HealthTree! #CME #MedEd
We report incidence of NPM1-wildtype relapses in pts treated with VEN-based frontline tx in AML.
🔴Overall, absolute # of relapses in NPM1 AML after VEN is ⬇️
🔴the fraction of NPM1-wildtype relapses ⬆️ with the⬆️ intensity of chemo backbone added to VEN.
🔴 NPM1 wildtype relapses occur later and often had MR mutations. And ALL (8/8) had a different flow immunophenotype compared to original AML.
🔴We proposed that these were ‘new’ AMLs, that arose from common preleukemic (CH) precursor, but that the original NPM1-mutated AML was ‘cured’.
https://t.co/MTYuZEW15S
@AjHematology
Very much looking forward to this meeting. Looking forward to great discussions and presentations from key US and international leaders on AML & ALL. Hoping you can join! @_MDEducation@jaltmanmd@TapKadia@doctorpemm@Ramikomrokji