Timofey Lebedev

[Timofey Lebedev @Timofey_LTD]

Our paper is finally out in Oncogene! It took years of research, 15 months from the first submission and 10 rejections. Despite all that I really appreciated how reviewer's suggestions made this paper better. We will post more details about this work soon.

[Oncogene Journal @oncogenejournal]

#OpenAccess from @CancerCell_Lab! 👩‍🔬👨‍🔬

Consideration of growth factor signalling activity benefits #Neuroblastoma outcome prediction and tailoring therapy regimens

👉 https://t.co/O0rCAKUwbm

@Timofey_LTD, @Elya_Elmira_Mi

[Timofey Lebedev @Timofey_LTD]

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[ANT.FUN OFFICIAL @ant_fun_trade]

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[Volodymyr Nechyporuk-Zloy @vnzloy]

An integrated platform for high-throughput phenospace learning of 3D multilineage organoid systems
Ryo Okuda et al.
https://t.co/0eytHYdLn2

[Nature Biotechnology @NatureBiotech]

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes - @PKU1898 https://t.co/lqj9yeq40H

[Anirban Maitra @Aiims1742]

Integrated cell atlas and tumoroids chart #PancreaticCancer therapeutic targets
https://t.co/dvU8MuEH4C
Website for pancreatic cancer scRNA seq atlas:
https://t.co/Vd6Ly225qN

[Hans Clevers @HansClevers]

3/11 Using long-term live imaging & tracking (by @_amolf), we followed hundreds of extrusion events. Most villus cells extruded alive, not apoptotic. Extrusion did not correlate with density.

[Hans Clevers @HansClevers]

1/11 In @ScienceMagazine: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. https://t.co/Y2EI9bhhWT

[Cell Biology J-Club @cell_club]

Restoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation | PNAS https://t.co/5V5vyhjDmW

[Timofey Lebedev @Timofey_LTD]

@AdrianoAguzzi Recently we got our paper automatically transferred between two CellPress journals without corresponding author actively agreeing to the transfer. While he was considering transfer they've already done it. Didn't even think such thing was possible.

[Waggoner Lab @LabWaggoner]

Real-time visualization of STAT activation in live cells using genetically encoded biosensors 🇨🇭
https://t.co/cLOv7o7nng

[Calì_Lab @lab_cali]

Proud to share the collaborative work with @NasuLab_IBC & @Campbell_FPs (Robert E. Campbell)! Split biosensors have been developed to intrinsically monitor membrane contact & Ca²⁺ exchange simultaneously—no chemical fluorophores required! 👉 https://t.co/e562JyYR11"

[Eric Betzig @Eric_Betzig]

Apoptotic vesicle release from a cell as it gives up the ghost under oxidative stress, as seen by MOSAIC lattice light sheet mode.

[Blood Journals Portfolio @BloodPortfolio]

Elevated B12 serum levels are associated with the presence of clonal hematopoiesis https://t.co/8QAHTZfaNV #myeloidneoplasia #clonalhematopoiesis

[Molecular Cell @MolecularCell]

Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision https://t.co/SlJ5SYSXLY

[Anirban Maitra @Aiims1742]

Preprint from @dow_lab @WeillCornell using CRISPR base editing screens:
Genetic mechanisms of resistance to targeted KRAS inhibition
https://t.co/2jOLx1TzM6
MAPK reactivation remains the predominant mechanism of resistance to KRASinh. Also identifies a hotspot mutation in CiC.

[Christoph Bock Lab @ CeMM & MedUni Vienna @BockLab]

🛡️How do macrophages tailor their defenses to different pathogens? Our new paper in @CellSystems combines dense multi-omics time series with high‐content CRISPR screens (CROP-seq) to map the regulatory landscape underlying macrophage immune responses. #Immunity #Screening (1/9)

[Prof. Nikolai Slavov @slavov_n]

You can find these and a million more dose–response curves in this resource article:

Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics

https://t.co/McIF1mLx1l

[Oncogene Journal @oncogenejournal]

A new article shows how tumor-associated #macrophages' extracellular vesicles drive regulatory T cell differentiation and #glioma progression, revealing potential new therapeutic targets for combating this type of tumor.
Read now 🔗

https://t.co/5R8w6fjP51

[Ming "Tommy" Tang @tangming2005]

1/ No, you do not always need single-cell RNA-seq.
Here's why bulk RNA-seq might still be the smarter move for your experiment.

[Hao Yin @HaoYin20]

My continued biomedical education

Re-imagining human cell culture media: Challenges, innovations, and future directions

Table 1 summarizes pros & cons of commonly used culture media

#AI
High-throughput Omics (epigenomics metabolomics proteomics)
Automation

On-demand optimization of xeno-free, chemically defined culture media

"...as most fields clung to DMEM/RPMI—formulations ill-suited for human cells' lower antioxidant capacity and distinct nutrient uptake"😬

Critical reading for one of the most important consumables in biomedical research🥸

Stanislav Sokolenko lab Biotechnol Adv 2025
https://t.co/gQuO3W9Rs3