Why do some inflammatory bowel disease patients benefit from anti-TNF therapy whilst others do not?
Our new @NatImmunol resource paper investigates this question by following patients before and after treatment: https://t.co/AmOpIBwqjB 👇
The career question I get asked the most is “why did I become a Physician-Scientist” - too often I give a vanilla answer to this - some colleagues have a Eureka moment- for me it was uncertainty, failure & extraordinary mentorship that set me on my journey https://t.co/RpTHgDuwCM
NICE says genetic testing before initiating clopidogrel is a cost-effective use of NHS resources for patients at risk of stroke
https://t.co/hsiOOkyaq6
Today's #JEMLegacy@JExpMed highlights the work of Fiona Powrie @powrie_lab & colleagues showing #Treg cells constitutively express #CTLA-4 and signaling via CTLA-4 is essential for their function to control intestinal inflammation. https://t.co/QgHHi2ntnh
Proud to be part of Dexter, as a tool for clinical trials. Dexter can help with quality improvement, predictive analytics and informatics consult in addition to observational studies and clinical trials. @KrishnaGokhale @UoB_IAHR @HDR_UK@JohtChandan
Do T cells remember what we eat? In @JExpMed, Lockhart, @danmucida et al @RockefellerUniv show that physiological exposure to food protein drives CD4+ T cell accumulation, clonal selection, and transcriptional adaptation at the intestinal epithelium. https://t.co/sdf4474qNB
Excited to share another Bioinformatician position in our lab based on our recent fundings!! Great opportunity to develop computational AI methods for longitudinal #SingleCell omics for translational medicine! https://t.co/20Lx1ltNCG @CUBiomedInfo@CURheumatology DM me directly🙌
To celebrate the release of THE BOOK THAT WOULDN'T BURN...
...everyone who retweets this g̷e̷t̷s̷ ̷a̷ ̷c̷a̷r̷ ... I mean is in the draw for a signed, dedicated copy ... I'll even number it for you!
Very happy to announce that today two papers on #PhIPSeq in (1) the general population (🧵 by @sea_andreu) and (2) in patients with inflammatory bowel diseases (#IBD), got published today in @ImmunityCP https://t.co/N1VhJNijEJ
https://t.co/8wCMV3YeEp 🧵 on IBD findings:
Delighted to share our paper on mitochondrial dynamics in B cells and lymphoma. Really grateful to my supervisor @a_j_clarke for his invaluable support and mentorship. Huge thanks to my co-supervisor @MichaelLDustin, collaborators and colleagues @KirOxford & @UniofOxford
We are thrilled to share the first publication from the McAlpine lab! Out today in @ImmunityCP.
“Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis”
@IcahnMountSinai@SinaiHeartBlood@SinaiBrain
https://t.co/WlWY1fFRa9