HAlsoW

Learnin' about stuff

[HAlsoW @TrialPivot]

@MartinShkreli just finished it, amazing read. any books for dummies on biologics that you'd recommend?

[Flick @flickartHQ]

We raised $6M to bring the future of filmmaking into your hands. Today, the premiere of our first Flick Residency Film Series is now live.

14 filmmakers. 13 films. All made on Flick.

Founded by filmmaker @ZoeyZ1004 and Instagram Stories founding engineer @RuiCromwell . Backed by @trueventures , @GVteam , @ycombinator (@garrytan , @golda ), @lightspeedvp, @pioneer_fund, Formosa Capital, @OliveTreeCap , and N1.

[HAlsoW @TrialPivot]

@kevinakwok fairly common chinese tech structure i'd say

[HAlsoW @TrialPivot]

@ZichenWanghere sue their PRC counsels or international ones?

[Gaurab Chakrabarti @Gaurab]

Eli Lilly is suing the FDA to classify retatrutide as a biologic. Retatrutide's main chain has 39 alpha amino acids. Lilly makes it with solid-phase synthesis, the standard chemistry for peptide drugs. Under FDA law, a biologic has more than 40 amino acids. Above 40, solid-phase synthesis yield collapses. Each coupling cycle runs at 99% efficiency, and that compounds over the chain. After 40 cycles, 67% of the target remains. The rest is deletion impurities you can't separate out. Past that point, manufacturers switch from reactors to living cells, where ribosomes assemble proteins at 99.99% accuracy and proteasomes break down the defective ones. The FDA wrote its 2020 rule at 40 because that's where chemistry breaks. Retatrutide sits one residue below the line. That means 5 years of exclusivity instead of 12. Compounders can legally make copies during shortages. Medicare can negotiate the price in 9 years, not 13. Classifying it as a biologic would flip all three. We run both chemistry and fermentation in our plants to produce industrial chemicals. Those are the same two processes that make peptides and biologics. Lilly gave up a little on Zepbound to lock in a 12-year monopoly on retatrutide.

[Alex Rampell @arampell]

https://t.co/g8rNXBe8Lh

[mark bissell @MarkMBissell]

to win gold medals and nobel prizes you just need to be funmaxxing

[HAlsoW @TrialPivot]

@HaoYin20 @NoahAITech 感谢！re: 参考文献非常新，想起最近看到国内某医学AI产品测评结果：它极度热衷于堆砌参考文献，却发生了最严重的证据污染。

[HAlsoW @TrialPivot]

@Kimi_Moonshot love the album selections

[HAlsoW @TrialPivot]

HELP NEEDED: A close friend is undergoing chemo + io therapy to combat metastatic breast cancer (🖕). She'd love a video to help visualize how these drugs and her immune cells attack and destroy cancer. played around with vid gen models, but no luck. Would love any help

[Siqi Chen @blader]

over the weekend, i built an app that i sincerely hope you will never have a need for, but if you do happen to need a friendly, free, private mri viewer designed to make it easy for you to track tumor progression, you can try it here: https://t.co/DQeMgOjDhM

here's the story:

as some of you may know, last last september, my six year old daughter mira was diagnosed with an extremely rare brain tumor called an adamatinomatous craniopharyngioma, and since then our family has been doing everything we can possibly do to find a cure for her.

we tortured chatgpt deep research, put together our own private research team, raised $1.4M and donated it all to @HankMitraLab research thanks to $MIRA, explored every remotely applicable drug whether on the market or not, and even began working with md anderson to develop a personalized vaccine that we hope can lead to a more permanent cure

unfortunately, we received the devastating news last march that the tumor has continued to grow since her initial surgery, and we had to start to consider more drastic options which would have seriously impacted mira’s quality of life.

thankfully, with the help of dr. sabine mueller @UCSFChildrens and the @HankMitraLab at the university of colorado, in april, we started her on an alternative but extremely experimental treatment for this disease.

to our unimaginable relief, her tumor has responded extraordinarily well to this treatment which combines tocilizumab (an arthritis drug that blocks IL6 receptors) with avastin (a colon cancer drug that inhibhits VEGF proteins).

we know this, because mira gets an MRI scan of her brain every few months.

and every time we get a new scan, the first thing we do is compare it against her last scan. so we have to find the matching weight of the scan, and then find the same plane, and then carefully find the slices of the scan where the tumor is visible, and then find the closest match to last month’s scan, then adjust the zoom, rotation, and brightness / contrast so they all look the same.

we got pretty good at this.

but it shouldn't be this hard.

so i built https://t.co/77sBd5thMI last weekend using gemini 3 with some gpt 5.2 xhigh.

you just import your DICOM MRI files (either zip, files or a folder), and you can align all of your scans across multiple dates instantly,

just click and drag a rectangle around the tumor on any image, and it will use some very clever algorithms to automatically align up and find the closest matching slice from all your other scans, match the brightness / contrast, rotation, pan, zoom, and even shear to make sure the registration is as close as possible, and make it as easy to possible to compare tumor progression.

it has a grid view so you can see all your scans for the same location all at once, and an overlay view so you can quickly compare two scans visually (by holding down the space bar to toggle quickly between two scans), along with tools to animate your scans both within the same sequence as well as over multiple scans to show progression.

there is no server, it runs entirely locally on your browser - nothing ever gets uploaded and it's all open source: https://t.co/9cOmDAZZID

if you've found this useful, please consider a donation to the @UCSFChildrens hospital foundation, who has given us extraordinary care over the past year or so:

https://t.co/wAvSxJFxTA

[HAlsoW @TrialPivot]

@james_riney too funny lol: a vital, active elderly population that refuses to retire

[HAlsoW @TrialPivot]

@kevg1412 what book/article is this from? thanks!

[HAlsoW @TrialPivot]

@andrewpannu CMC transferability has become the rate-limiting step - curious what source data you used to generate this conclusion (using Sleuth)? Is it qualitatively?

[Yuchen Jin @Yuchenj_UW]

We’re entering Software 3.0: a world where everyone can build personalized software and ship new features in minutes, and the cost is ~$0.

Software used to be built by companies with lots of engineers, now it’s built by individuals.

[HAlsoW @TrialPivot]

@CryptoPainter 没看明白，可以解释下吗

[HAlsoW @TrialPivot]

@mackenziejem great insights, would love to read the full post!

[HAlsoW @TrialPivot]

@bodenlosig fascinating, thank you!