Tyler Lefevre

PhD candidate / AHA Predoctoral Fellow at the University of Michigan • G protein biochemistry and signaling nut(job) • @UMChemBio @UMPharmacology

[Tyler Lefevre @TylerLefevre_]

Amazing job @steministnat!! Well deserved!

[Smrcka Lab @AlanSmrcka]

Big congratulations to Nathalie Momplaisir @steministnat winning 1st place in the Delores Shockley Competion at ASPET @ASPET #ExpBio #expbio2022 Yeah!

[Nathalie Momplaisir (she/her/hers) @steministnat]

Exciting findings from @AlanSmrcka lab!!
Check out this new paper that looks into novel interactors of G𝛼i.

Great work @NaincyChandan et al.

[Kirill Martemyanov Lab @KLabGPCR]

Can a #GPCR structure still surprise you? Happy to present #CryoEM structure of an orphan receptor GPR158.
https://t.co/uTvlX803ai
Couples to RGS instead of G proteins.
Features an extracellular Cache domain for ligand binding
Forms a unique tight dimer stapled by phospholipids

[Kirill Martemyanov Lab @KLabGPCR]

What do we know about how crucial mediators of GPCR signaling- the Gβγ subunits are released? It was a joy covering recent work on the topic by @KevMKnight @HenrikDohlman @TylerLefevre_ @AlanSmrcka @VaidehiLab
https://t.co/mns7c2raEU

[Tyler Lefevre @TylerLefevre_]

@angelinelyon @ASPET @AlanSmrcka @NaincyChandan Thank you, Angeline! 😁

[Tyler Lefevre @TylerLefevre_]

Had a great first #ExpBio conference! Thanks to @ASPET and of course to @AlanSmrcka and @NaincyChandan. Looking forward to the GPCR Colloquium session in a couple weeks!

[Smrcka Lab @AlanSmrcka]

Congratulations @TylerLefevre_ for winning third place ASPET Molecular Pharmacology Division Poster Award!

[Tyler Lefevre @TylerLefevre_]

@jenkins_paul @ASPET @AlanSmrcka @NaincyChandan Thanks Paul!!

[Tyler Lefevre @TylerLefevre_]

@steministnat Thanks Nat 😁

[Tyler Lefevre @TylerLefevre_]

It never works until it does! My proposals were scored *very* differently. It is so hard, but I'm learning that you have to cast a wide net and be persistent to even have a chance.

[Tyler Lefevre @TylerLefevre_]

I'm funded!

Thanks to @AHA_Research for believing in my science! And of course, immense thanks to @AlanSmrcka and all others who mentored and supported me before and throughout this process.

Big congrats to Kobi and Rob as well, two very dedicated and deserving researchers!

[Smrcka Lab @AlanSmrcka]

Congratulations to Tyler Lefevre @TylerLefevre_ in the Smrcka Lab @AlanSmrcka and Rob Goldsmith and Kobe Essandoh in the Brody Lab for receiving American Heart Association @AHA_Research pre-doctoral and post-doctoral fellowships!!!!

[Tyler Lefevre @TylerLefevre_]

And now the soapboxy post-script: we tend to highlight only our successes on these platforms, so I want to show transparency for all of the self-doubters out there (including myself). This isn't the only fellowship I applied for this year, but it was the only one I received.

[Tyler Lefevre @TylerLefevre_]

Looks like I was wrong, welcome @KevMKnight!

[Tyler Lefevre @TylerLefevre_]

@weinberz @UMPharmacology @AlanSmrcka Thanks Zara! It was a delight to be a part of this effort with (twitterless) Kevin, @HenrikDohlman, and others 😄

[BryanRoth @zenbrainest]

PSYCHEDELIC!!!
At long last--30 years of work-finally!
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor https://t.co/SaSSa4WHPL

[Tyler Lefevre @TylerLefevre_]

The Leaders and the Best never pass up an opportunity to offer a friendly reminder in times of crisis

[University of Michigan @UMich]

@chloecastrosan1 Hi Chloe. We acknowledge that some students are choosing to celebrate their return, & want to ensure they do so as safely as possible by offering friendly reminders of the protocols at U-M & @wcpublichealth guidance, including direction on face coverings & the size of gatherings.

[Tyler Lefevre @TylerLefevre_]

@steministnat PEAK EFFICIENCY 💯💯💯

[Tyler Lefevre @TylerLefevre_]

!!!

Engineered nanobodies continue to deliver.

🤞🤞🤞 in vivo studies

[BryanRoth @zenbrainest]

WOW!!!
An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation https://t.co/GapcwdwVng

[UMLifeSciences @UMLifeSciences]

The plans are set and the #CryoEM suite is prepped and ready. Installation of the LSI's second #Krios begins next week!

[Tyler Lefevre @TylerLefevre_]

Excellent work @GissellASancz 😁

[Smrcka Lab @AlanSmrcka]

Congratulations! to Gissell Sanchez in my lab for her successful NIDA diversity supplement proposal!