Smrcka Lab

We study GPCR regulated signal transduction pathways

[Jerry Madukwe @JerryMcJer]

It was great meeting Dr. Namandje Bumpus @BumpusLab , the Chief Scientist of the US FDA and the current president of @ASPET today during #ASPET2023.

Read an article in @trendsinpharma discussing one of her works.

https://t.co/Lr8PLwaWkH

[Isaac Fisher @IsaacFisher_]

Congratulations to this year's
@ASPET mol pharm postdoc competition winners! Ashley Nilson, Francesco De Pascali, and G. Aditya Kumar #ASPET2023 #molpharm #pharmacology

[Angeline Lyon Lab @angelinelyon]

Congrats to Kennedy Outlaw!! She won 1st place Mol Pharm undergrad poster at ASPET 2023!!!!

[Smrcka Lab @AlanSmrcka]

Congratulations to Wenhui Wei who won 1st place in the Cardiovascular Showcase Trainee Competition @ASPET ! #ASPET2023

[Smrcka Lab @AlanSmrcka]

The crew at #ASPET2023

[Smrcka Lab @AlanSmrcka]

Wei did a wonderful job delivering her talk on the opposing effects of beta 1 and beta 2 signaling in cardiac hypertrophy.

#ASPET2023

[Nathalie Momplaisir (she/her/hers) @steministnat]

I’ve had the pleasure of chairing the Pharmacology in Color symposium with @MPuthenveedu at the @ASPET conference this year. I’m grateful that I’ve been able to be in the planning team @UMPharmacology and branch it out to @ASPET .

[Journal of General Physiology @JGenPhysiol]

Our latest Research News: Morales et al. (https://t.co/jvWiv98LD7) reveal how the neurotransmitter PACAP induces a secretory response in chromaffin cells that differs from the one induced by acetylcholine. https://t.co/AGzliDI3sF

@AlanSmrcka

[Smrcka Lab @AlanSmrcka]

Congratulations to @TylerLefevre_ who is now a Ph.D.!

[Maria Falzone @MariaFalzone9]

Very excited to share the first paper from my postdoc in the MacKinnon lab as a preprint. We’re studying PLCb enzymes, which cleave PIP2 to produce IP3 and DAG downstream of GPCR activation. (1/4)

https://t.co/8QF7LCRrTn

[Gissell A Sanchez @GissellASancz]

I’m honored to be recognized for my most recent publication 😌Thank you to @AlanSmrcka for nominating my work to be highlighted 🙏🏻🙌🏻

[Journal of General Physiology @JGenPhysiol]

Morales, Smrcka, Anantharam et al @UToledoMed show that PACAP, an important neurotransmitter at the splanchnic-chromaffin cell synapse, operates through a pathway involving Gαs, PLCε, & L-type calcium channels https://t.co/jvWiv98LD7
#CellularPhysiology #IntercellularSignaling

[Dr. Lori L. Isom @LoriLIsom1]

Congratulations to @UMPharmacology 2022 Outstanding Alumni Speaker, Dr. Ezra Lowe, and his graduate mentor, Dr. Yoichi Osawa!

[Jin Zhang Lab @jinzhanglab]

Excited to share our new paper out in @Nature , led by our postdoc @Dr_Yonghoon. We report the discovery of spatially organized GPCR-mediated ERK signaling using biosensors. #GPCR #ERK #biosensor #imaging #CellSignaling 1/6
https://t.co/X5Xi4oyRHL

[Smrcka Lab @AlanSmrcka]

Check out our new paper in led by @GissellASancz in a team effort from the @AlanSmrcka, @DrSusieLIngram1 and @Jutkiewicz_Lab labs. A nice complement to the recent work by @KLabGPCR on Gq targeting and opioid antinociception. https://t.co/OPa3dC0gzm.

[Kirill Martemyanov Lab @KLabGPCR]

Our paper by @subhimarwari and @CodyKowalski is out today in @BrJPharmacol. We find that pharmacological blockade of Gq/11 suppresses activity of DRG neurons, their inhibition by opioids and has analgesic effects in mice.
https://t.co/8heqJeMKRq

[Rachel Kolodny @rachelkolodny]

We report 57 multi-GPCR proteins, identified with a sequence-based search, and then used #AlphaFold to predict their 3D structures. Here is an example: the predicted structure (with 2 7TMs) of A0A3L7HXX2from Cricetidae (a rodent)🐿️(pLDDT 81.5).(4/11)

[Terry Hébert @THebertMcGill]

There is an upside!

https://t.co/CssCXQjoDE?

[Smrcka Lab @AlanSmrcka]

@Jen_Cash_11 Awesome!

[Kirill Martemyanov Lab @KLabGPCR]

Really nice review on location-selective GPCR signaling in neurons by @MPuthenveedu Lab!
https://t.co/CxEt8YPPRr