World class science and a lot of fun during our 2023 GPCR symposium! Nice turnout for a Saturday, thanks to Brian Kobilka and all the speakers for making this happen! @UCSDHealthSci@UCSDPharm @joann_trejo @NewtonLab @LabSkiniotis @tesmer_john
Giving ERK a jERK from the endosome
New Spotlight article from Evi Kostenis, Sergi Bravo, & Jesus Gomeza highlighting @Nature research article on non-canonical β-adrenergic activation of ERK at endosomes by @jinzhanglab@UCSDPharm
https://t.co/v4dvVHTkBu
Transient β2-AR dimerization drives receptor constitutive activity, which is disrupted by the inverse agonists
📰 Subscribe to the @DrGPCR Newsletter Today!
➡️https://t.co/E4Jk5KeIb1
#gpcr#drgpcr@yaminaberchiche@AttilaForis
Out today in @Nature, work from Dr. Jin Zhang @jinzhanglab reveals a non-canonical mechanism for GPCR-mediated kinase activation
The findings could change the textbook model of #GPCR signaling and suggest untapped potential for future drug development 💊
https://t.co/BaVamJcOcf
Excited our exploration of non-canonical GPCR-mediated ERK signaling is out today in #Nature! We discovered how the cell is spatially organized to control the signaling. Many thanks to everyone who helped out with this project!
Excited to share our new paper out in @Nature , led by our postdoc @Dr_Yonghoon. We report the discovery of spatially organized GPCR-mediated ERK signaling using biosensors. #GPCR#ERK#biosensor#imaging#CellSignaling 1/6
https://t.co/X5Xi4oyRHL
Save the date - DEC 6 - 3rd Annual Roger Tsien Cell Signaling Distinguished Lecture, this year expanding to a half day symposium with poster session, prizes, reception. Thank you @bmsnews for the generous support. @UCSDPharm
Free registration: https://t.co/TBQOVyyuLK
Online now! Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inverse agonism https://t.co/5FljbzANzZ #chembiol
I’m truly honored to receive the 2023 BPS Carolyn Cohen Innovation Award that recognizes the work of our students, postdocs and collaborators. Many thanks for all the support! – JZ
@UCSDPharm@CellSignalingSD@UCSDMedSchool@ResearchUCSD
It was a bittersweet farewell to @schmittwitt_ yesterday. Thank you for all you have contributed to the lab over the last 4.5 years! We know the @schmittlab_ucla will do amazing things at @uclachem !
💡Lighting Up AMPK💡🔬 We used a new AMPK biosensor to unravel mechanisms for AMPK activity at the lysosome, mitochondria, & nucleus. Out now in @NatureComms
https://t.co/Cs2aXJjqcl
Spotted at Phosphorylation and G-Protein Mediated Signaling Networks #GRC: Zhang Lab Postdocs! Current postdoc Dr Yonghoon Kwon @Dr_Yonghoon met up with former postdoc & current @PSBehrend asst prof Dr Jeremiah Keyes @KeyesDiscovery!