Excited to share our preprint on bacterial chromosome organization. Using Hi-C data-driven simulation modeling of B. subtilis, we reveal that *cooperation* between the SMC and ParAB proteins drives faithful segregation of the replicating genome (Ori segregation).
Researchers from @riceuniversity and partnering institutions have discovered ancient chromosomes in the preserved remains of a 52,000-year-old woolly mammoth, providing insights into the history of life on Earth that were previously thought impossible. https://t.co/6LrcaGbpll
New @BiophysJ article! Sustained enthusiasm by @BenjaminSRuben who started this project as an undergraduate has led to this. We studied how chromosomes behave under mechanical stress by simulating their axial stretching https://t.co/8WBl17YSrG
For a summary of our main findings, see this tweet from co-author @sumitabha590: https://t.co/WORloidMKO
Thank you also to @DiPierroLab, @Vini_Contessoto, Ryan Cheng, Antonio B Oilveira Junior, and José N. Onuchic for making this work possible.
Genomic architectures are far more diverse than previously believed; yet, the physical processes that form this diversity should be similar, because molecular evolution is slow. In our latest work we argue that: 1/4
https://t.co/7r3ZJHexLm
Excited to share @NAR_Open: Shaping the #genome via #lengthwiseCompaction, #phaseSeparation, and #lamina adhesion. Competition between these three thermodynamic forces recapitulates #chromosome-level organizational features seen across species. https://t.co/lwTJxdOzU3
Happy to share this very nice study that I had the opportunity to participate in. Thanks to the CTBP team: Esteban Dodero-Rojas, Paul Whitford, and José N. Onuchic.
Rice, Rutgers developing inhalable COVID-19 vaccine spray https://t.co/k3Zs2PIvg0
Today we launch the Nucleome Data Bank (NDB), a web-based platform to simulate and analyze the three-dimensional organization of genomes. The NDB is available at https://t.co/vXviYwCp6Z. Check it out! https://t.co/pdVgdhqEaU
Check out our new paper in @ScienceMagazine ! A marriage of theory and experiments in collaboration with the Center for Theoretical Biological Physics, Benjamin Rowland @NKI_nl, @theaidenlab, @thednazoo, and many other institutions across the world. https://t.co/WWONIpEGQa
Excited about a new collaboration between the Rowland, Onuchic, Di Pierro, and @theaidenlab labs and @thednazoo which was led by @odudcha Ahmed Elbatch, Claire Hoencamp and Sumitabha Brahmachari, appearing in @ScienceMagazine today. A tweetorial!