Marius Wernig

We in the Wernig lab are excited about coding neurons and glia by reprogramming and develop human cell models and next generation cell therapies for the brain

[Marius Wernig @WernigLab]

Check out our next-generation stem cell (iPSCs)- & CRISPR-based approach to treat dystrophic epidermolysis bullosa. Hot off the press: https://t.co/7w4HKJy55k

#cellandgenetherapy #regenerativemedicine #genomeengineering #DEBRA #CIRM

[Marius Wernig @WernigLab]

A reactive myeloid state is neuroprotective in chronic neuroinflammation that can be enhanced by microglial replacement! Congrats to @marius_mader and all co-outhors in collaboration with @wysscoray and Larry Steinman. thanks @NatureNeuro! https://t.co/9GTIGUFC36

[Marius Wernig @WernigLab]

Great achievement!

[Alice Ting @aliceyting]

LYTACs pioneered by @CarolynBertozzi opened the door to degradation of cell surface and extracellular proteins through lysosomal targeting. Here, we introduce genetically-encoded LYTACs, or GELYTACs, which are (1) easier to produce by recombinant expression (LYTACs, antibody conjugates to glycopeptides, are harder to make), (2) amenable to engineering via directed evolution, and (3) possible to secrete from therapeutic cells such as T-cells.

We demonstrate degradation of various soluble targets, including TGFb, IL6R ectodomain, and mCherry with GELYTACs optimized via yeast display directed evolution, added either as recombinant protein or secreted from living T-cells.

Congratulations to lead author @Jony_theChemist, our wonderful collaborators Sean Yamada-Hunter, @LouaiLabanieh and @molecular_elena from the @mackalllab, and great teaming up again with the formidable @CarolynBertozzi.

https://t.co/WVYAadruBP

[Marius Wernig @WernigLab]

Excited to share that Cheen’s paper got published in PNAS today! We found that Emx1+Ngn2 produces more homogeneous excitatory forebrain neurons than Ngn2 alone. https://t.co/B8JQIctOvT. Thanks @PNASNews and all co-authors!

[Marius Wernig @WernigLab]

All Molecular/Cellular Neuroscientists interested, please apply!

[Stanford Neurosurgery @StanfordNsurg]

Stanford Neurosurgery seeks a basic or translational neuroscientist with a proven track record in molecular and cellular neurobiology to join the Department as Assistant, Associate or Full Professor. @StanfordBrain #neurojobs #neurotwitter

Apply here: https://t.co/7AExBrsWvW

[Kyle G Daniels @ScienceKyle]

The Next Gen Faculty Symposium is back!

If you’re a postdoc or grad student going on the faculty job market, this is a great launching pad.

https://t.co/wUZMDOG4Fs

Organized by @fordycelab @airstreets Jason Sello
of @UCSF @Stanford and @UCBerkeley

Please retweet 🙏

[Marius Wernig @WernigLab]

Check out our new exciting @CellStemCell paper that shows microglia replacement can restore Trem2 function in a mouse AD model. Congratulations Yongjin @yongjinyoo and the other contributors from the lab!
https://t.co/vY06NmhSuB

[Marius Wernig @WernigLab]

Check out our new paper where we identified a neuroprotective microglial state in chronic EAE enhanced by hematopoietic cell transplantation. Congrats to @marius_mader and team and thanks to our collaborators Larry Steinman and @wysscoray! https://t.co/VSVEjF2Pa1

[Marius Wernig @WernigLab]

Congrats - a great accomplishment!

[Levi Todd @Levi_J_Todd]

Our newest endeavor to regenerate neurons from glia is out now @ScienceAdvances. In this paper we try and coax Muller glia to regenerate retinal ganglion cells (Brief overview below)
https://t.co/PPpIAacrv3

[Marius Wernig @WernigLab]

Thrilled to share our new paper by @_justynajanas on the surprising role of Tip60 on H2A.Zac, neuronal fate specification and bivalent gene activation. Many thanks to our collaborators, Or Gozani, Peter Jackson and @eliaslab1, and to @MolecularCell! https://t.co/foBzEKAHM7

[Marius Wernig @WernigLab]

Congratulations @abu_remaileh Lab! very elegant study.

[Marius Wernig @WernigLab]

congratulations to Koji @IPeaceInc_J and Hiroko to have accomplished the successful conversion of human fibroblasts to iOPCs!! and thanks to @Dev_journal for publishing it

[Development @Dev_journal]

In their Open Access Research Article, Koji Tanabe, Hiroko Nobuta, Marius Wernig @WernigLab and colleagues present their protocol for rapid generation of human oligodendrocytes from human dermal fibroblasts. 2/10
#OpenAccess #ReadandPublish
https://t.co/zPmsdVOQkT

[Marius Wernig @WernigLab]

Check out iPeace Inc. by Koji Tanabe, Shinya's former student and my former postdoc at Thursday's lunch showcase at #ISSCR2022 annual meeting in SF. He is truly transforming iPS cell generation enabling autologous applications.

[Marius Wernig @WernigLab]

So wonderful to meet colleagues and friends in person again. Thanks @YaleSCC for inviting me and this picture! I truly enjoyed my visit. See you soon again at @ISSCR meeting in San Francisco!

[Marius Wernig @WernigLab]

Myt1l is a powerful reprogramming factor and high confidence autism gene. In a great collaboration with @MarkusWohr and @SudhofThomas labs we found intriguing behavioral phenotypes in Myt1l+/- mice. Congrats and thanks to all co-authors!

[Markus Wöhr @MarkusWohr]

Our Myt1l study on the @SFARIorg top-ranked autism candidate gene is now published with @SpringerNature in @MolecularAutism. Collaborative project @Stanford supported by @AvHStiftung. Thanks to @WernigLab and @SudhofThomas lab members for all the support. https://t.co/Nd5F2QIipk

[Marius Wernig @WernigLab]

Thank you @nyscf for this nice summary and interpretation of our paper!

[New York Stem Cell Foundation Research Institute @nyscf]

Can #microglia be harnessed as a therapy? NYSCF – Robertson #StemCell Investigator Alumnus @WernigLab and team incl. NYSCF – Druckenmiller Fellow @yongjinyoo found a way to replace the immune cells of the brain, improving neurological disease in mice: https://t.co/rfgnoV2Dzp

[Marius Wernig @WernigLab]

Congratulations Beth! It is great to see that iPS- derived MG can recapitulate disease states so well.

[beth stevens @stevens1lab]

How do genetic and environment interact to alter microglia states and functions in health & disease?
Excited to share preprint collaboration with @macosko led by @MartineTherrie4 @dolanmjg @sasajereb and many others
https://t.co/MgIDcuCfZF
1/x

[Marius Wernig @WernigLab]

Pharma scientists remain in strong support of Anti-Abeta therapy

[Alzforum @alzforum]

At AD/PD, Aβ immunotherapy scientists showed new analyses of old data to try to bolster their claim that clearing plaque slows cognitive decline. #alzheimersdisease https://t.co/Gl0GXGIpu5

[Buck Institute @BuckInstitute]

The Buck Institute for Research on Aging has an opening for a new faculty member at Assistant, Associate, or Full Professor. We are seeking an outstanding candidate who works on the Biology of Aging and/or Age-Related Diseases.
Job link: https://t.co/iZ4TmUoVh5 #sciencejobs

[iPS細胞研究所 @CiRA_KU_J]

【3/29 23:30〜放送】江藤浩之教授がNHK Worldの番組「Science View」に取り上げられます。iPS細胞から血小板を大量に作って、輸血に利用する研究を進めています。研究の最前線を紹介しています。ぜひご覧ください。※英語での放送です。 #iPS細胞 #血小板 #輸血
https://t.co/FDCSloTWZB