❗️New kind in town of immunomodulatory signaling metabolites in macrophages❗️
We describe D-2HG among the top-induced immunometabolites in inflammatory macrophages that serves as a negative feedback loop to resolve inflammation
➡️https://t.co/3ZaiwbheGZ
It’s out! Our guide for everyone new to studying macrophage metabolism 🧫
@immunometlab@XanthevD@RafaJArguello & our two first authors 👏🏻
An integrated toolbox to profile macrophage immunometabolism https://t.co/1YzcFCLy4D
How lipid droplet flux within macrophages controls inflammation-roles for hypoxia-inducible lipid droplet–associated protein and intracellular adipose triglyceride lipase @PNASNews https://t.co/fQKCDaG8vU
The last chapter of my Ph.D. thesis was just published in #PNAS! Interested in how the breakdown of triglycerides from lipid droplets can regulate the inflammatory response in macrophages? Read this👉https://t.co/TzFc3RioRp
Happy to share publication of our protocols for studying immune cell metabolism in vivo: coupling stable isotope metabolite infusion with bead-based sorting of immune cells. https://t.co/eqIxxOAq6s @VAInstitute@VAIMetabolism
So happy to announce that our short spotlight article for @trendscancer on recent work by the @Platten_lab just got published! 😀 Read our thoughts on macrophages and glioma-derived R-2HG here: https://t.co/BnI8GYctoI
@XanthevD, Kyra and I just wrote a spotlight article for @trendscancer on the recent @NatureCancer paper from @Platten_lab on the effect of IDH-mutant-derived R-2HG on macrophages in gliomas: https://t.co/gAjNswV2En
Coolest cover ever!
Not sure which technique(s) to select to profile your favorite cell’s immunometabolism?
We set up an immunometabolic profiling toolbox and applied it to human and mouse LPS vs IL-4-stimulated “M1/M2” macrophages.
We = @RafaJArguello, @XanthevD, @GorkiRike & others not on Twitter
Proud to share our work extending the concept of #mitohormesis, an evolutionarily conserved stress adaptation promoting #longevity and #metabolic health, to the restraint of #inflammation in the mammalian innate immune system! @NatMetabolism full-text > https://t.co/AKSmVa1zTp