Xikun Han

Statistical genetics & cellular genomics

[Xikun Han @XikunHan]

At ASHG 2025 held in Boston, I presented our latest research: leveraging complex disease genetics and evolution to dissect cross-ancestry genetics, selection, pleiotropy, aDNA introgression, and G*E🌹
Hope run a half marathon next time—the conference really cut running! 😄

[Xikun Han @XikunHan]

We analyzed 100k+ abstracts (1999–2024) from ASHG & ESHG over the past two decades. https://t.co/C9Bht9dM9J
@medrxivpreprint @biorxivpreprint @biorxiv_genetic @ejhg_journal @eshgsociety @GeneticsSociety @AJHGNews
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[Xikun Han @XikunHan]

These results highlight the ongoing disparities in both research output and global visibility within human genetics conferences.
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[Xikun Han @XikunHan]

Equity in human genetics research requires balanced participation not only from study participants from global populations but also from the researchers who drive the science.
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[Xikun Han @XikunHan]

GDP and Nature Index Share, representing the economic and scientific capacity, respectively, were identified as key determinants of the average number of abstracts and oral presentations.
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[Xikun Han @XikunHan]

At the European Society of Human Genetics (ESHG 2025) held in Milan, I presented our latest research progress: leveraging complex disease genetics and evolutionary genomics to investigate the genetic circuits of complex diseases and putative therapeutic targets. 🌹🌹🌹

[Manolis Kellis @manoliskellis]

Don't miss @XikunHan 's #ASHG talk on #SingleCell dissection of #BipolarDisorder starting now Room207A/Level 2 (11:15am, Friday) #ASHG23 Integrate: 88 samples, 500k cells, #GWAS, single cell-#eQTLs in 2.3M cells
Results: #BD differentially expressed genes (#bdDEGs), enriched pathways, cell types, modules, #RegulatoryNetworks
Mendelian randomization #causal #driver genes and putative #therapeutic targets
Team: @XikunHan, @brad_ruzicka, @ShahinMohammadi, #PsychENCODE, #KikiGalani, #LiLunHo in @Panos_Roussos and @ManolisKellis labs. Very proud of the whole team at @MIT, @BroadInstitute, @MIT_CSAIL,@IcahnMountSinai, @MITEECS, @MIT_SCC
More info: https://t.co/NGLbA5NKIE Big thanks to: @NIH and #PsychENCODE project

[Xikun Han @XikunHan]

Thrilled to announce our research published in @NatureGenet, substantially advancing our understanding of #glaucoma genetics! @stuartmacgreg @QIMRBerghofer @UQMedicine @uk_biobank @clsa_elcv @23andMeResearch @GLAUCOMA @glaucoma @TGF_Glaucoma @GlaucomaToday
https://t.co/dxhwbmzNo3

[Nature Genetics @NatureGenet]

🔥 OUT TODAY @NatureGenet
📰 Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
🧑🏿‍🤝‍🧑🏻 Xikun Han, Puya Gharahkhani and colleagues
👇🏼
https://t.co/PHKrJIpKCm

[Xikun Han @XikunHan]

Excited to publish our work at AJHG https://t.co/KuuFL7sErI @stuartmacgreg @Trzaskow1Maciej @AJHGNews

[Xikun Han @XikunHan]

We use automated AI labelling of 280,000 optic nerve images to dramatically improve gene mapping power for glaucoma and enable new insights into cross-ancestry glaucoma risk. @uk_biobank @clsa_elcv @GWAS_lit @biorxiv_genetic @QIMRBerghofer @UQMedicine @GLAUCOMA

[Xikun Han @XikunHan]

I have been incredibly lucky during the PhD journey to work with Stuart, and greatly appreciate the amazing mentorship -- supportive, friendly and approachable.

[Stuart MacGregor @stuartmacgreg]

The amazing Xikun Han @XikunH heads off to Harvard soon for his postdoc. Best of luck Xikun - congratulations on a series of excellent papers from your PhD (16 published to date, with more pending).

[QIMR Berghofer @QIMRB_Institute]

During #WorldGlaucomaWeek, we are highlighting the work of Prof @stuartmacgreg & his team, who are calling for volunteers to participate in the #GeneticsofGlaucoma study. Visit the website for details: https://t.co/X1rDuSrYjG

#GlaucomaWeek2021 #Glaucoma

[Stuart MacGregor @stuartmacgreg]

Change of scenery saves a grandmother’s sight from glaucoma https://t.co/51e0RPkmTX

[Stuart MacGregor @stuartmacgreg]

The folks at GoogleHealth have applied a ML approach to optic nerve measures, resulting in increased power for GWAS. They use a different training set, but their results compare well with the ones we derived in conjunction with @maxkelsen https://t.co/cj4uDxIAHg

[Xikun Han @XikunHan]

We use automated AI labelling of 280,000 optic nerve images to dramatically improve gene mapping power for glaucoma and enable new insights into cross-ancestry glaucoma risk. @uk_biobank @clsa_elcv @GWAS_lit @biorxiv_genetic @QIMRBerghofer @UQMedicine @GLAUCOMA

[Stuart MacGregor @stuartmacgreg]

We use automated AI labelling of optic nerve images to dramatically improve gene mapping power for glaucoma https://t.co/cj4uDxIAHg

[JAMA Ophthalmology @JAMAOphth]

The MYOC p.Gln368Ter variant has a high penetrance in OHT and #glaucoma. Our study suggests the need for early screening and identification of p.Gln368Ter carriers to prevent the progression of glaucoma. https://t.co/hRPsujI23e