๐ New preprint! scXpand โ the first ML framework to detect T-cell clonal expansion from scRNA-seq (no TCR needed). Built on 2.6M T cells, robust across cancers & TME contexts.
๐ Led by Ofir Shorer & @RonAmit5
๐ https://t.co/AbL4vlDczF
๐ข Excited to share our new paper in @CellGenomics!
We analyzed matched #scRNAseq and #scTCRseq from 767K T cells to uncover clonal programs that predict response to immune checkpoint inhibitors.
๐ https://t.co/EKs9ETZfoZ
#CancerImmunotherapy
๐จ New preprint alert! We performed scRNA-seq & scTCR meta-analysis on cancer patients treated with ICIs, revealing key T cell signatures linked to therapeutic response, with insights into clonal replacement vs reinvigoration! #scRNAseq#Immunotherapy
https://t.co/d35nY6dfIf
Iโm happy to share our new paper showing moonlighting function of ASS1 in the nucleus. Under the tough circumstances we are facing this paper would have never been published without the help of a wonderful editor, great collaborators and resilient students. Thank you all! โฅ๏ธ
We celebrate the much-deserved selection of @gaddyg to this yearโs class of 2024 AACR Academy Fellows!! Congrats, Gaddy ๐! https://t.co/2RaO1YtW7f
@MGHCancerCenter @broadinstitute
Happy to share this work lead by Daniel Schaffer, using a deep learning model to identify microbial RNAseq reads that are assembled into longer contigs. We find that the presence of several microbial genes strongly predicts outcomes in esophageal cancer
https://t.co/SqPdAqeiJj
In these darkest days our country have ever known, we somehow manage to do science. Our new paper shows how #metabolism of immune cells predicts patients response to ICI. Ofir finished this paper while in reserve duty helping to bring our people back home
https://t.co/zE78skVSNB
An Open Letter to Every Parent In America
Please help me get this message out to every parent in the United States.
Please help me protect your children.
I am BEGGING you - "liking" this is not enough.
Please retweet right NOW.
https://t.co/a6asiL5HKZ
Before we have to pay to tweet, I want to post an opening for a PhD position at the Weizmann Institute for a student interested in characterizing the tumor MACROenvironment for therapeutic implications.
Check out our new #preprint on the metabolism of immune cells in the TME of patients treated with #immunotherapy led by Ofir Shorer. We analyzed scRNA-seq from >1M cells and found a metabolic signature predictive of response across cancer types. https://t.co/gmHKvWPAbf
We had a great time at the #ILANIT2023 meeting. Very proud of my team with 4 talks, 3 posters, 3 runners and one fun lab outing which as usual, we forgot to take a photo of.