Alex Young

Principal Research Fellow @uclcs @UCL_Hawkes | Disease progression modelling | Heterogeneity | Neurodegenerative diseases | Machine learning

[UCL POND @POND_UCL]

#AAIC2025 Wednesday TALK by @chris_ucl from @POND_UCL: 2pm, session 4-23-DEV.
"Longitudinal trajectories of advanced cortical diffusion-weighted imaging measures of tissue microstructure in pre-symptomatic autosomal dominant Alzheimer's disease"

[UCL POND @POND_UCL]

#AAIC2025 Wednesday POSTER by @DrMaitreiKohli from @POND_UCL & MANIFOLD lab:
Wednesday-410. "AutoML-Multiverse: Model Agnostic Framework for Optimizing Individual-level Alzheimer's Disease Classification"

[UCL POND @POND_UCL]

#AAIC2025 Monday POSTER by @LawrenceBinding from @POND_UCL:
Monday-437. "Uncovering regional atrophy not explained by tau deposition using Additional Pathology Inference (AddiPath)"
A new SuStaIn... :-)

[UCL POND @POND_UCL]

#AAIC2025 Monday TALK by @YoungAlexL from @POND_UCL: 4:15pm, session 2-32-FRS-A.
"Disease timeline modelling of amyloid and tau PET reveals dynamic timescales of amyloid and tau accumulation in Alzheimer's disease"

[Alex Young @YoungAlexL]

The posts develop and apply foundation models, LLMs, and disease progression models to clinical records, neuropathology, imaging, omics, and biomarker data as part of the RLW BRAIN programme led by Prof Tom Warner and Dr Zane Jaunmuktane.

[Alex Young @YoungAlexL]

Two postdoc positions available developing and applying AI and machine learning tools for neurodegenerative disease research with Prof Danny Alexander and I.

Closing date 30th July.

https://t.co/9FDoWYtOdj

https://t.co/1yGC8H6fLz

@fishpiechicken

[Jake Vogel @_JakeVogel_]

‼️PhD Position now available in my lab‼️

Do you like:
* Neurodegenerative disease?
* Neuroimaging and/or multi-omics?
* AI and data-driven life science?

Want to work with @RikOssenkoppele Alexandra Young and Laura Wisse?

Apply here: https://t.co/aQ3g5pZWJe

Please rt/share 🙏

[Junhao (Hao) Wen @JunhaoWen]

@AndrewZalesky and I will organize a symposium on "Unraveling brain heterogeneity across scales, systems, and diseases" at OHBM 2025! We have a great line-up of speakers (@YoungAlexL @chrisdav66 @yetianmed, Maria Di Biase, and myself) who will discuss cutting-edge topics, including AI/ML subtyping, multi-organ, and multi-omics modeling!

Check info here: https://t.co/D9x9piyqOZ

See you in beautiful Australia this summer/winter! @OHBM

[@BrainComms @braincomms]

Estarellas et al. report that an adapted Subtype and Stage Inference algorithm accommodates missing data in multimodal #Alzheimersdisease studies. @mar_estarellas @UCLMIGPOND @NeilOxtoby @jmschott @fishpiechicken @YoungAlexL
https://t.co/2GMz4avfj4

[Ellie Thompson @e_thompson93]

For more network-spreading goodness, check out Sonja Soskic's poster (Monday-910), where she uses the toolbox to model the impact of neurotransmitter receptors on amyloid and tau accumulation ✨ @POND_UCL @CmicUcl

[Ellie Thompson @e_thompson93]

I'll be talking about multi-modal connectomes for modelling tau spread on Wednesday morning (4-2-FRS-D) and showcasing our group's network spreading model toolbox tomorrow at the AIC and in the poster session on Monday (Monday-475, AIC-340) 🧠🧠🧠 https://t.co/5u08UM8jmy

[Jake Vogel @_JakeVogel_]

I am hiring a research technician to help process and analyze multimodal neuroimaging data. Please RT!!

* Great opportunity to gain research experience pre-PhD

* Access to exciting data

* Opportunities for independent projects

Apply here:
https://t.co/PT3kuBXHei

[RikOssenkoppele @RikOssenkoppele]

Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

@SEMastenbroek strikes again!

Using SuStaIn modeling of neuropathological data (n=814) we show substantial heterogeneity in the temporal spread of Lewy body pathology, with 81.9% showing earliest pathology in the olfactory bulb while 18.1% initially exhibited abnormalities in brainstem regions.

Link to @biofinder_study thread > https://t.co/t4jRYy5dz6

Link to paper @NatureComms > https://t.co/JeCvzCnfLs

w/@BannerHealth, @AlzheimerAms @_JakeVogel_, @LECollij, @YoungAlexL, @cece_tremblay, @FBarkhof & @OskarHansson9

[Dave Cash @davecash75]

The first @eumind_congress takes place on 25-27 September in Caen, Normandy. The deadline for submitting your neuroimaging abstracts and travel awards is today. Be sure to submit!
https://t.co/qZ5wqYzupF

[Gemma Salvadó @gesalbla]

Extremely happy to see this one out at last!!!🎉🎊
Here, we showed that a single CSF draw 💉is sufficient to accurately stage participants along the #Alzheimer's continuum.
This has been a long and tough journey, but totally worth it to finally share it with the whole community☺️

[Jake Vogel @_JakeVogel_]

‼️ Postdoc ad // Please RT/circulate ‼️

Are you interested in
* Big euroimaging and multi-omic data?
* Neurodegenerativ disease?

The @biofinder_study is looking for a talented postdoc to sink their teeth into some rare and exciting data!

Apply here:
https://t.co/VNuy96cazu

[William Scotton @drwillscotton]

New pre-print alert! The aim of this study was to identify imaging subtypes of CBS based solely on a data-driven assessment of atrophy patterns, to test the hypothesis that modelling disease subtype and stage jointly would provide information on underlying pathology in CBS.. 1/7

[WEISS @WEISS_UCL]

Are you an early-career scientist interested in learning about the latest advances in medical image computing? The 10th UCL Medical Image Computing Summer School (MedICSS 2024) will take place from 1st – 5th July 2024 in person in Central London. https://t.co/OrAGTQK0jW

[Ellie Thompson @e_thompson93]

Happy to see our work published in @ImagingNeurosci!
We compare different types of brain network for modelling pathology spread in AD, and show how we can combine the different networks to improve our models 🧠

Code here: https://t.co/9Ci72V07MX

@POND_UCL @CmicUcl

[Nature Rev Neurosci @NatRevNeurosci]

Data-driven modelling of neurodegenerative disease progression: thinking outside the black box — a Review by Alexandra L. Young, Neil P. Oxtoby, Sara Garbarino, Nick C. Fox, Frederik Barkhof, Jonathan M. Schott & Daniel C. Alexander

https://t.co/ptQcMIv1fZ