ZeminZhangLab

Director, Biomedical Pioneering Innovation Center (BIOPIC), PKU

[ZeminZhangLab @ZeminZhangLab]

🎉 Excited to see a News & Views by Dr. Mirjana Efremova (Barts Cancer Institute, QMUL) highlighting our work on multicellular coordination across tissues and its rewiring in cancer.

Grateful for the thoughtful commentary!

🔗 https://t.co/59EOox14pu

[Peking University @PKU1898]

Mapping how cells talk, organize, and transform. 🧬Researcher Zhang Zemin’s team from #PKU BIOPIC published in Nature, revealing cross-tissue multicellular coordination patterns and how they are rewired in cancer.

👉 Full paper: https://t.co/G0X1rRMyJ3

#PKUResearch #InnovateWithPKU

#PKU Biomedical Pioneering Innovation Center (BIOPIC)

[ZeminZhangLab @ZeminZhangLab]

@PKU1898 Many thanks for sharing👏👏👏

[ZeminZhangLab @ZeminZhangLab]

Our latest @Nature paper uncovers recurring cellular modules across tissues and their rewiring in cancer. @QiangShi7 @PKU1898

[nature @Nature]

Nature research paper: Cross-tissue multicellular coordination and its rewiring in cancer

https://t.co/TRM8a5pqWP

[ZeminZhangLab @ZeminZhangLab]

Our paper "pan-cancer single-cell panorama of human natural killer (NK) cells" is officially out in @CellCellPress. This study revealed NK cell heterogeneity, characterized their features and provided insights into new therapeutic strategies. Check it here https://t.co/aDdoVEFFKl

[Cell @CellCellPress]

In the latest issue! Accelerating the understanding of cancer biology through the lens of genomics https://t.co/87gXdWShXK

[ZeminZhangLab @ZeminZhangLab]

Our review paper "Accelerating the understanding of cancer biology through the lens of genomics" is now out in @CellCellPress, and so excited to have this opportunity. Check it out here https://t.co/eDefFrRJ5N

[Genome Biology @GenomeBiology]

Kang, @JrdCamps, Fan, Jiang, Shen, Bu, @ZeminZhangLab, Roider & co use bulk and single-cell RNA-seq to profile the microenvironment of gastric cancer. An immunosuppressive microenvironment correlates with poor prognosis and resistance to anti-PD1 treatment https://t.co/VqDkISiUGs

[ZeminZhangLab @ZeminZhangLab]

@FGinhoux @Nature Thank you Florent!

[ZeminZhangLab @ZeminZhangLab]

Our new paper is now out in @Nature. Together with #Ning Zhang lab and #Jiye Zhu lab, we define tumor immune microenvironment subtypes of liver cancer and highlight immunosuppressive functions of tumour-associated neutrophils. https://t.co/KEj10qsv5p

[ZeminZhangLab @ZeminZhangLab]

Nice study by @IdoAmitLab and @QuezadaLab

[Nature Cancer @NatureCancer]

⭐️ONLINE NOW @NatureCancer - “Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling” by @QuezadaLab @IdoAmitLab & Co.

Read it here👇
https://t.co/9fmvdouweG
https://t.co/huvEBjGsda

[ZeminZhangLab @ZeminZhangLab]

@simocristea Thank you very much for this kind introduction

[ZeminZhangLab @ZeminZhangLab]

@thommen_ds @NatureCancer @KapteinPaulien Thank you so much Daniela and @KapteinPaulien for this very nice commentary!!!🍺🍺

[ZeminZhangLab @ZeminZhangLab]

and also addresses that whether ICB in different cancer types induces the increase of terminally differentiated or precursor tumor-reactive CD8 T cells depends on the context of TME!

[ZeminZhangLab @ZeminZhangLab]

So excited that our paper "Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint blockade" is now out in @NatureCancer
. Check out the commentary https://t.co/jeOfo0bZoA and our paper here, https://t.co/RFnWpB2O7s…

[ZeminZhangLab @ZeminZhangLab]

This paper reveals that CXCL13 expression could accurately define both terminally differentiated and precursor tumor-reactive CD8 T cells, with the latter largely from post-ICB responsive tumors,

[ZeminZhangLab @ZeminZhangLab]

Very nice study from @MiriamMerad and colleagues that investigates how LAMP3+ mregDC, CXCL13 T helpers and tumor-specific CD8s cooperate to promote ICB efficacy in hepatocellular carcinoma

[bioRxiv Immunology @biorxiv_immuno]

Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade https://t.co/RxTrfyVqXf #biorxiv_immuno

[ZeminZhangLab @ZeminZhangLab]

Our perspective paper "Mapping cell types across human tissues" is now out in @ScienceMagazine, https://t.co/MtmtT4mWIq, and congratulations #HumanCellAtlas consortium on huge advances in building a comprehensive human single-cell atlas.

[ZeminZhangLab @ZeminZhangLab]

We are going to tweet now!!!