🎉 Excited to see a News & Views by Dr. Mirjana Efremova (Barts Cancer Institute, QMUL) highlighting our work on multicellular coordination across tissues and its rewiring in cancer.
Grateful for the thoughtful commentary!
🔗 https://t.co/59EOox14pu
Mapping how cells talk, organize, and transform. 🧬Researcher Zhang Zemin’s team from #PKU BIOPIC published in Nature, revealing cross-tissue multicellular coordination patterns and how they are rewired in cancer.
👉 Full paper: https://t.co/G0X1rRMyJ3
#PKUResearch #InnovateWithPKU
#PKU Biomedical Pioneering Innovation Center (BIOPIC)
Our paper "pan-cancer single-cell panorama of human natural killer (NK) cells" is officially out in @CellCellPress. This study revealed NK cell heterogeneity, characterized their features and provided insights into new therapeutic strategies. Check it here https://t.co/aDdoVEFFKl
Our review paper "Accelerating the understanding of cancer biology through the lens of genomics" is now out in @CellCellPress, and so excited to have this opportunity. Check it out here https://t.co/eDefFrRJ5N
Kang, @JrdCamps, Fan, Jiang, Shen, Bu, @ZeminZhangLab, Roider & co use bulk and single-cell RNA-seq to profile the microenvironment of gastric cancer. An immunosuppressive microenvironment correlates with poor prognosis and resistance to anti-PD1 treatment https://t.co/VqDkISiUGs
Our new paper is now out in @Nature. Together with #Ning Zhang lab and #Jiye Zhu lab, we define tumor immune microenvironment subtypes of liver cancer and highlight immunosuppressive functions of tumour-associated neutrophils. https://t.co/KEj10qsv5p
⭐️ONLINE NOW @NatureCancer - “Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling” by @QuezadaLab@IdoAmitLab & Co.
Read it here👇
https://t.co/9fmvdouweG
https://t.co/huvEBjGsda
and also addresses that whether ICB in different cancer types induces the increase of terminally differentiated or precursor tumor-reactive CD8 T cells depends on the context of TME!
So excited that our paper "Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint blockade" is now out in @NatureCancer
. Check out the commentary https://t.co/jeOfo0bZoA and our paper here, https://t.co/RFnWpB2O7s…
This paper reveals that CXCL13 expression could accurately define both terminally differentiated and precursor tumor-reactive CD8 T cells, with the latter largely from post-ICB responsive tumors,
Very nice study from @MiriamMerad and colleagues that investigates how LAMP3+ mregDC, CXCL13 T helpers and tumor-specific CD8s cooperate to promote ICB efficacy in hepatocellular carcinoma
Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade https://t.co/RxTrfyVqXf #biorxiv_immuno
Our perspective paper "Mapping cell types across human tissues" is now out in @ScienceMagazine, https://t.co/MtmtT4mWIq, and congratulations #HumanCellAtlas consortium on huge advances in building a comprehensive human single-cell atlas.