Zhang Lab@ISM

Big fan of T cell biology. Enthusiastic for developing next-generation therapeutic strategies against cancer.

[Zhang Lab@ISM @ZhangLabISM]

A Metabolite Gives Cytotoxic T Cells a Boost-Our recent study was selected as the cover story. Thanks to all our collaborators.

[Science Magazine @ScienceMagazine]

The metabolite citraconate can preserve T cell stemness and suppress exhaustion, promoting antitumor immunity and responses to immunotherapies in mice.

Learn more in @SciImmunology: https://t.co/PSdpeu68S8

[Zhang Lab@ISM @ZhangLabISM]

Our recent study was selected as the cover story. Thanks to our collaborators.

[Science Immunology @SciImmunology]

The May 2026 issue of Science #Immunology is out!

This month's cover depicts a cytotoxic #Tcell filled with citraconate molecules, which can enhance #antitumor responses and protect against exhaustion.

Learn about this research and more: https://t.co/8PGzy9jzKF

[Science Immunology @SciImmunology]

The May 2026 issue of Science #Immunology is out!

This month's cover depicts a cytotoxic #Tcell filled with citraconate molecules, which can enhance #antitumor responses and protect against exhaustion.

Learn about this research and more: https://t.co/8PGzy9jzKF

[Zhang Lab@ISM @ZhangLabISM]

@DrSTANtheMAN @ImmunityCP @PCHo_Lab Thanks Stan!

[Zhang Lab@ISM @ZhangLabISM]

Very glad to share our recent story about fostering DC-T cell crosstalk for anti-tumor immunity

[Waggoner Lab @LabWaggoner]

Engineered T cells stimulate dendritic cell recruitment and antigen spreading for potent anti-tumor immunity @CellRepMed
https://t.co/resI7sy1tf 🇨🇳

[Zhang Lab@ISM @ZhangLabISM]

Thanks to all for your great efforts

[Immunity @ImmunityCP]

Online now: Succinate preserves CD8+ T cell fitness to augment antitumor immunity https://t.co/G0W1myp2bz

[Waggoner Lab @LabWaggoner]

Malonate promotes CD8+ T cell memory formation via protein malonylation
https://t.co/cS52IPDwpD

[Zhang Lab@ISM @ZhangLabISM]

DCs are key for mounting effective antitumor immunity

[The Innovation: a Cell Press partner journal @The_InnovationJ]

New in The Innovation Medicine! Dendritic cells instruct T cell anti-tumor immunity and immunotherapy response.
In this review, Xiao et al. discuss recent advancements in our understanding of DC biology under homeostatic conditions and within the tumor microenvironment with a particular emphasis on insights gained through single-cell multi-omics. Read more @Innov_Medicine
https://t.co/SpiG3MwGHn
#Medicine #DendriticCells #research

[Hidehito HORINOUCHI @HHorinouchi]

🔥@trendscancer🆙
✅Turning cold into hot: emerging strategies to fire up the tumor microenvironment
🎯Summary of the intrinsic, extrinsic, and systemic factors developing ‘cold’ tumors
👥Dr. Kaili Ma
#LCSM @OncoAlert #ICI
https://t.co/p3IW9hjSOi

[Idrovo Lab @IdrovoLab]

Cystine deprivation triggers CD36-mediated ferroptosis and dysfunction of tumor infiltrating CD8+ T cells https://t.co/WPvOWrLDug

[Zhang Lab@ISM @ZhangLabISM]

Big Congratulation! @UtzschneiderD!

[CSL @CSL]

Boosting exhausted T cells: Dr Daniel Utzschneider has identified how T cells can become exhausted from battling cancer, reducing the effectiveness of immunotherapy. He will use his CSL Centenary Fellowship to study these cells. @TheDohertyInst https://t.co/KytXyaExsR

[Zhang Lab@ISM @ZhangLabISM]

@TheDohertyInst @UtzschneiderD @CSL @UniMelbMDHS @TheRMH Big Congrats, Daniel!

[HoLab @PCHo_Lab]

An excellent collection of reviews covering anti-tumor immune cycle.

[Zhang Lab@ISM @ZhangLabISM]

@PCHo_Lab @sallustolab @fabien_franco Congratulations Ping-Chih!!!

[Zhang Lab@ISM @ZhangLabISM]

@MathiasWenes @MiglioriniDenis @ArberCaroline @AlisonJaccard @PCHo_Lab @UNIGEnews @OncoUNILCHUV Big Congrats!

[Zhang Lab@ISM @ZhangLabISM]

@vannini_lab Thanks Nicola, looking forward to your visit.

[Zhang Lab@ISM @ZhangLabISM]

Our study about ERAD and CD8+T cell survival and homeostasis was just out at Cellular & Molecular Immunology. Congratulations to all the authors and collaborators.

[Idrovo Lab @IdrovoLab]

SEL1L preserves CD8+ T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis https://t.co/ynghpnXmzn

[Zhang Lab@ISM @ZhangLabISM]

@MathiasWenes Many thanks, Mathias!

[Zhang Lab@ISM @ZhangLabISM]

@vannini_lab @Auwerx_Lab @PCHo_Lab @GrNave @OncoUNILCHUV @Ludwig_Cancer Bravo, Nicola!

[Nature Metabolism @NatMetabolism]

Online now! Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness https://t.co/WtQfnbSl9a