Zuen Ren, M.D., Ph.D.

Physician-scientist; Husband; Father of my Daughter. Graduated from @EinsteinMed working on breast cancer @MGHCancerCenter & @harvardmed (Opinions are my own)

[Anthropic @AnthropicAI]

This is the first result from our new molecular biology lab, where a team of Anthropic biologists is using Claude to explore and accelerate fundamental biology research. There, Claude works through data and literature to generate hypotheses and candidate biological systems to study. After our scientists review Claude’s hypotheses, they test the most promising ideas, with all lab work done by our scientists.

We’d like to extend this approach to a broad range of problems—in genomics and in other fields. If you have a proposal for a research question, we’d like to hear from you.

[Zuen Ren, M.D., Ph.D. @ZuenRen]

Thrilled to be part of the team at MGH funded by the Gray Foundation to continue our work on dissecting the early pathogenesis of hereditary breast cancer.
The Gray Foundation Announces $35 Million in New Funding for BRCA-Related Cancer Research - https://t.co/HNeXjBT7PJ

[Zuen Ren, M.D., Ph.D. @ZuenRen]

(2/2) The deregulated nucleotide pools drive chemoresistance, while producing ATR checkpoint dependence that represents a metabolic vulnerability of chemoresistant TNBC. https://t.co/kY3iNuX5Vn

[Zuen Ren, M.D., Ph.D. @ZuenRen]

(1/2) In a recent preprint on bioRxiv https://t.co/kY3iNuX5Vn, we identified that SIRT5 is frequently overexpressed in chemoresistant TNBC due to copy number gain and amplification, and elevated SIRT5 orchestrates a coordinated metabolic switch to expand nucleotide pools.

[AACR President Keith T. Flaherty @AACRPres]

As I begin my term as @AACR President, I thank Lillian Siu for her inspired leadership over the past year. I look forward to working with the entire cancer community to advance our shared mission to prevent and cure all cancers. #AACR26

[Beverly Moy @BeverlyMoy]

Join me and @Thalcin @adawaksmd @AnaVManana @SWentMD @MGBCI_BreastOnc @MassGenBrigham @DFCI_BreastOnc @UCSFCancer @DukeCancer & many more at Best of ASCO Boston! Registration is free.

[Zuen Ren, M.D., Ph.D. @ZuenRen]

We identify a "A SIRT5-induced metabolic switch underlies chemoresistance and ATR checkpoint dependence in triple-negative breast cancer". Feedback welcome.
https://t.co/jOuFdIJJ76

[Zuen Ren, M.D., Ph.D. @ZuenRen]

Ludwig Harvard's Zuen Ren https://t.co/sXTe1PfQFX via @YouTube

[Joseph Burclaff @JosephBurclaff]

A new paper discussing the importance of federal, institutional, and programmatic support for physician scientist trainees. The same can easily apply to biomedical trainees. We as a nation need to support the next generation of doctors and researchers! https://t.co/MwmJjYnFb8

[Zuen Ren, M.D., Ph.D. @ZuenRen]

Today I had so much fun to run 5K alongside my friends and colleagues at @MGHCancerCenter @MGHBreastOnc @MGBResearchNews. We run together for one goal that is to conquer cancer.

[Zuen Ren, M.D., Ph.D. @ZuenRen]

Check out Zuen Ren's fundraising page - https://t.co/TTtOuoqJyK

[Zuen Ren, M.D., Ph.D. @ZuenRen]

Check out MGB Breast Program's team fundraising page - https://t.co/uu08NNqMEw @MGH_WiO @MGHBreastOnc @MGHCancerCenter

[Zuen Ren, M.D., Ph.D. @ZuenRen]

Ludwig Harvard's @ZuenRen at #AACR25 https://t.co/Er5Kgbf0X9 via @YouTube I am thrilled and grateful to be a part of the @Ludwig_Cancer Harvard community. Working within this esteemed environment provides me with incredible opportunities to advance my cancer research. @AACR

[Vindhya Vijay @Vindhya_Vijay]

Thrilled to share our work mapping dependencies in molecularly distinct, lineage-based BTC subtypes.

Extremely thankful to @targetcancer for believing in this work from the very beginning and to @curecc for multiple research fellowships that helped make this possible.

[Zuen Ren, M.D., Ph.D. @ZuenRen]

Thanks so much for such a great event #AACR25. Another year of great success for the @AACR conference. Truly encouraging to see the community grow. Importantly, gratefully appreciated for the support from the AACR grant to me and the opportunity to meet up great people @CD_AACR

[AACR @AACR]

Day 3 of #AACR25 showcased the latest advances from across the cancer research continuum—including two clinical trials plenary sessions on Advances in Immunotherapy and New Frontiers in Precision Oncology.

[Zuen Ren, M.D., Ph.D. @ZuenRen]

@Be_Marian88 @ScienceAdvances Congrats Mariana! This is an exciting paper!

[Dana-Farber’s Breast Oncology Center @DFCI_BreastOnc]

Excellent poster session at the @df_hcc Breast and Gynecologic Cancer Symposium. Thank you to all who submitted posters!

[Zuen Ren, M.D., Ph.D. @ZuenRen]

Thanks so much for hosting such a wonderful event! Really brings us together to share brilliant insights on Women’s cancer awareness.

[Dana-Farber’s Breast Oncology Center @DFCI_BreastOnc]

Zuen Ren, MD, PhD (@ZuenRen) shares new research looking at how SIRT5 promotes #chemoresistance through metabolic rewiring for nucleotide replenishing in refractory #TripleNegativeBreastCancer at the @df_hcc Breast & Gynecologic Cancer Symposium. https://t.co/v0dz4yxa9g

[X. Edward Guo 郭向东 @edguo84]

No words.