Charles Nelson

Based in Matsumoto, JAPAN. Obsessed w/ Rapamycin, Spermidine, mTOR, Autophagy, Fasting, Sulforaphane and the Hyperfunction Theory of Aging.

[Charles Nelson @_Rapamycin]

At 53yo, I can either take #Rapamycin, try avoiding protein and activating mTOR and wither away from Sarcopenia.

… OR think that it’s bringing down my over-activated (Hyperactive) mTOR levels to a balanced one that I had in my youth, and EAT and TRAIN like an athlete.

[Healthspan @healthspanmed]

Chronic overactivation of mTOR is at the foundation of many age-related diseases.

As we get older, mTOR may stay active all the time—opening the door to out-of-control cell growth that can lead to cancer and closing the door on cell repair.

Learn more: https://t.co/kL7N4IEZjz

[Mikhail V. Blagosklonny, MD PhD Professor Oncology @Blagosklonny]

Rapamycin (sirolimus) prevents #insulin resistance during resistance exercise (RE). #rapamycin increases insulin sensitivity, while not preventing muscle hypertrophy caused by exercise. In brief, rapamycin plus RE is a double benefit
https://t.co/ZYERW1u12f

[Mikhail V. Blagosklonny, MD PhD Professor Oncology @Blagosklonny]

@DrCamMaximus In contrast, rapamycin preserves muscle and prevents sarcopenia

https://t.co/cFSg01BEhi

[老化さん by NOMON & Co. @NOMON_and_Co]

ビックニュースだよ！🧠

アルツハイマー病の脳で暴れてる「異常なタウタンパク質」、なんと本わさびの成分が片づけてくれるって話が出てきたの。

タウってね、リン酸っていう飾りが異常にいっぱいく���ついて脳内にゴミとして溜まると、神経細胞を壊していく厄介な存在。
これがアルツハイマー病の正体のひとつなんだけど、今回の発見がちょっとすごくて。

本わさびに含まれる「ヘキサラファン」という成分が、そのリン酸の飾りを切り落とす酵素（PP2A）の働きをパワーアップさせるらしいの。
飾りをくっつける側を止めるんじゃなくて、切り落とす側を強化するっていう、ちょっと意外な攻め方なんだよね。

しかもこの効果、細胞の防御システムとして有名な「NRF2経路」とは関係なく起きてるの。
つまり、ヘキサラファンには今まで知られてなかった独自の武器があったってこと。

マウス実験では、脳内だけじゃなく血液中の異常タウまで減って、さらに長期間飲ませたマウスは認知機能や運動能力まで改善。
脳の神経同士のつながり（シナプス可塑性）も回復してたんだって。

お寿司の横に添えてあるだけじゃなかったんだよ、本わさび。
身近な食材の中に、まだ誰も気づいてない力が眠ってるかもしれない。
そう思うと、なんだかワクワクしない？🌿

[Charles Nelson @_Rapamycin]

@hima72087 @soshi_okamoto Metformin 500mg daily and Rapamycin 5mg once a week on 3 consecutive catabolic days followed by 3 anabolic days heavy weight training. Cycling mTOR is the only way to stop Hyperfunction theory of aging.

I plan to live until at least 150 years old.

[Krister Kauppi - Rapamycin Longevity Lab @KristerKauppi]

More than 100,000 people die every single day because of aging. Not because they want to. Not because they’re ready. But because aging biology forces them to. It's a brutal reality. We watch our parents, relatives, friends, people we love or idols suffer from pain, functional decline and age-related diseases. It's seldom a peaceful thing. The fight against death starts way too late in life and gets very desperate in its character. We wait until big damage is done and then scramble to patch symptoms.

The image connected to this post highlights a massive problem in our life which is that we are stuck in an Old Paradigm (sickcare). Society spends 99.99% of its efforts on treating the symptoms of aging, specific age-related diseases like cancer, heart disease and dementia. It’s like trying to patch holes in a rapidly sinking ship. When one hole is plugged then another inevitably appears. It's just a matter of time. This approach is very costly, inefficient and will not be long-term sustainable. We will never win this fight if we only focus on the symptoms.

We must start to shift our focus from symptoms to target the root cause of age-related diseases, which is aging itself. By targeting aging, we have a far better chance to delay or even reverse all age-related diseases simultaneously. It’s time to modernize our approach and work smarter on the core problem. Currently only a tiny fraction of resources goes to this area. It's time to start prioritizing the root cause and stop postponing things.

Aging touches every life, whether through personal experience or the stories we witness around us. It brings decline, disease and loss but it may not need to remain this way. By targeting aging itself we may be able to rewrite the story of human life.

Our future depends on which paradigm we choose to support. Which paradigm gets your support?

[Charles Nelson @_Rapamycin]

@healthspanmed The “Hyperfunction theory of Aging” is so interesting.

[Charles Nelson @_Rapamycin]

@jpsenescence @Itilon Brilliant.

[Charles Nelson @_Rapamycin]

@agingdoc1 You will be sadly missed.…. 😢 RIP my friend. I still think of you often when taking Rapamycin or studying the Hyperfunction Theory of Aging. Thank you so much for all your contributions to the Longevity Field. You’re a genius. A legend!

[Charles Nelson @_Rapamycin]

@calculatist That is 20%. Are there properties at that low price level in Karuizawa? I went to Karuizawa yesterday, from Minami-Minowa. Job hunting for real estate work opportunities.

Karuizawa is truly beautiful.

[Charles Nelson @_Rapamycin]

@anku505 I’m taking Rapa/Acarbose until I get too gassy, then I’m switching over to Rapa/Met for a while. Back and forth… I prefer the Rapa/Acarbose though.

[Charles Nelson @_Rapamycin]

@KristerKauppi Just because I thought it would be good for my body.

[Charles Nelson @_Rapamycin]

@scott4670 All the time!! lol, super duper vitamin K2. Also, I think it tastes like coffee a little. And I like coffee.. 🤙🏻

[Mikhail V. Blagosklonny, MD PhD Professor Oncology @Blagosklonny]

high protein (good). Low/restricted protein extends lifespan in animals when given at birth, during developmental growth, yearly in life.
ALL nutrients activate mTOR.
Just combine protein with rapamycin

[P.D. Mangan Health & Freedom Maximalist 🇺🇸 @Mangan150]

Decreasing your glycogen stores is a key to increasing insulin sensitivity, and with aerobic exercise, it may take hours to deplete them.

High-intensity exercise can do that in minutes.

[P.D. Mangan Health & Freedom Maximalist 🇺🇸 @Mangan150]

A low ratio of triglycerides/HDL means a low risk of heart disease even when LDL ("bad") cholesterol is high

A high ratio means higher risk even with low LDL.

Triglyceride/HDL ratio is related to insulin resistance, not cholesterol.

https://t.co/1Ay91aC3VP

[Charles Nelson @_Rapamycin]

@Jmachadopt Usually I log it once a week, every Sunday.

[Charles Nelson @_Rapamycin]

@AtillaOzmumcu Yes, I do! Trying to avoid Sarcopenia as much as possible..

Animal protein, Whey Protein, Creatine + a Keto friendly diet. Lots of Vegetables/Fiber.

[Charles Nelson @_Rapamycin]

@KristerKauppi I don’t eat a high protein diet.

My main goal is to eat like I normally did when I was in my 20’s , while balancing my mTOR levels through #Rapamycin AND do resistance training (to avoid Sarcopenia).

I think the key is to bring mTOR down, not to inhibit it altogether.

[Charles Nelson @_Rapamycin]

An “epic podcast” is an understatement! This episode is packed with such brilliant and invaluable information..

[Krister Kauppi - Rapamycin Longevity Lab @KristerKauppi]

In this epic podcast episode I interview the world's leading Rapamycin researcher @Blagosklonny. His contribution to moving the Rapamycin longevity field forward has been huge and we would not be here where we are today without all his great work and passion in the field. I feel that this episode took my longevity knowledge to the next level. Especially because of these three key takeaways.

1⃣ I got a deeper understanding of the hyperfunction theory and how mTOR drives age-related diseases and why Rapamycin is a promising candidate to delay this process. But also why for example centenarians probably live a longer life.

2⃣ The hyperfunction theory also fits well with my current mindset and the theory was like a big missing puzzle piece that I found. I feel thanks to this that my overall work with my own longevity journey will improve a lot. The theory will not often give detailed answers on specific cases but I think it will help me in guiding me in the right general direction in different cases.

3⃣ It was interesting to get Mikhail’s view on the glucose regulating drug Acarbose and that he personally prefers a low carb diet when combining it with Rapamycin. I’m already satisfied with the levels of carbs in my diet that I eat today. It’s not a high carb diet or a ketogenic diet but something in the middle. So things point more and more to the fact that I will try to add Acarbose to my longevity stack at the beginning of next year. I don't want to decide yet what I will do so I will keep the door open for other alternatives until January when I do some kind of improvement to my longevity protocol.

We were all shocked when Mikhail recently revealed that he was diagnosed with lung cancer which had spread to his brain. What he is now dedicating his life to really shows what unique person he is. He is now using his passion, knowledge and his great mind to develop a new form of treatment to cure his cancer. This is his life mission now and this is something he will share with us in the future. May the force be with you, my friend 🙏

PS Link to the epic podcast in my bio. I can highly recommend the youtube version with the bonus slides.

[Charles Nelson @_Rapamycin]

@KristerKauppi Thanks for the rebound effect info., Krister!
Very interesting.