Today we introduce human neural loop #assembloids created from 4 parts derived from stem cells to study the cortico-striato-midbrain-thalamo-cortical pathway and to model neurodevelopmental disease
Work led by the remarkable Ji-Il Kim
and Yuki Miura in the lab. Also in collaboration with the @marius10p lab at @HHMIJanelia
Video shows a four-part neural assembloid displaying emergent synchronized activity after a couple of hundred days of integration
Today we are sharing our most complex #assembloid to date: a 4-part model of the human ascending neural somatosensory pathway generated by functionally integrating stem cell-derived cerebral cortical, thalamic, spinal and sensory #organoids.
Check out the @biorxivpreprint and a short video of activity as these parts self-assemble
Work led by the multi-talented Ji-il Kim & Kent Imaizumi
https://t.co/MjHOBya05Q
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Read our #preprint on @researchsquare: https://t.co/TP6GjKLxFq
A fantastic collaboration with colleagues in Ulm, that builds on our collective previous work.
Have a look if interested in human synaptic proteomics, iPSCs and reversible convergent disease mechanisms in ALS