Charles Nelson

Based in Nagano, JAPAN. Obsessed w/ Rapamycin, Spermidine, mTOR, Autophagy, Fasting, Sulforaphane and the Hyperfunction Theory of Aging.

[Charles Nelson @_Biohacking]

@jpsenescence @Itilon Brilliant.

[Charles Nelson @_Biohacking]

@agingdoc1 You will be sadly missed.…. 😢 RIP my friend. I still think of you often when taking Rapamycin or studying the Hyperfunction Theory of Aging. Thank you so much for all your contributions to the Longevity Field. You’re a genius. A legend!

[Charles Nelson @_Biohacking]

@calculatist That is 20%. Are there properties at that low price level in Karuizawa? I went to Karuizawa yesterday, from Minami-Minowa. Job hunting for real estate work opportunities.

Karuizawa is truly beautiful.

[Charles Nelson @_Biohacking]

@anku505 I’m taking Rapa/Acarbose until I get too gassy, then I’m switching over to Rapa/Met for a while. Back and forth… I prefer the Rapa/Acarbose though.

[Charles Nelson @_Biohacking]

@KristerKauppi Just because I thought it would be good for my body.

[Charles Nelson @_Biohacking]

@scott4670 All the time!! lol, super duper vitamin K2. Also, I think it tastes like coffee a little. And I like coffee.. 🤙🏻

[Will Ahmed @willahmed]

Product review @whoop coach:
“It's a dawning of an era of truly smart wearables – and ironically it's one with no screen that's leading the way.” ⁦@wareable⁩ https://t.co/fRNI70ilCF

[Mikhail V. Blagosklonny, MD PhD Professor Oncology @Blagosklonny]

high protein (good). Low/restricted protein extends lifespan in animals when given at birth, during developmental growth, yearly in life.
ALL nutrients activate mTOR.
Just combine protein with rapamycin

[P.D. Mangan Health & Freedom Maximalist 🇺🇸 @Mangan150]

Decreasing your glycogen stores is a key to increasing insulin sensitivity, and with aerobic exercise, it may take hours to deplete them.

High-intensity exercise can do that in minutes.

[P.D. Mangan Health & Freedom Maximalist 🇺🇸 @Mangan150]

It's a pernicious myth that you can't be lean and healthy as you get older, say at 68, my age.

You don't have to be medication-dependent and declining in health.

It doesn't even require much time.

But it has to be your priority.

[P.D. Mangan Health & Freedom Maximalist 🇺🇸 @Mangan150]

A low ratio of triglycerides/HDL means a low risk of heart disease even when LDL ("bad") cholesterol is high

A high ratio means higher risk even with low LDL.

Triglyceride/HDL ratio is related to insulin resistance, not cholesterol.

https://t.co/1Ay91aC3VP

[Charles Nelson @_Biohacking]

@Jmachadopt Usually I log it once a week, every Sunday.

[Charles Nelson @_Biohacking]

My RECOVERY improved by 3% in the Recovery Impact Analysis on my #WHOOP by taking my 10mg of #Rapamycin a week.

Thats not bad!

[The Rapamycin is taken instead of the Multivitamin].

[Charles Nelson @_Biohacking]

@AtillaOzmumcu Yes, I do! Trying to avoid Sarcopenia as much as possible..

Animal protein, Whey Protein, Creatine + a Keto friendly diet. Lots of Vegetables/Fiber.

[Charles Nelson @_Biohacking]

@KristerKauppi I don’t eat a high protein diet.

My main goal is to eat like I normally did when I was in my 20’s , while balancing my mTOR levels through #Rapamycin AND do resistance training (to avoid Sarcopenia).

I think the key is to bring mTOR down, not to inhibit it altogether.

[Charles Nelson @_Biohacking]

An “epic podcast” is an understatement! This episode is packed with such brilliant and invaluable information..

[Krister Kauppi - Rapamycin Longevity Lab @KristerKauppi]

In this epic podcast episode I interview the world's leading Rapamycin researcher @Blagosklonny. His contribution to moving the Rapamycin longevity field forward has been huge and we would not be here where we are today without all his great work and passion in the field. I feel that this episode took my longevity knowledge to the next level. Especially because of these three key takeaways.

1⃣ I got a deeper understanding of the hyperfunction theory and how mTOR drives age-related diseases and why Rapamycin is a promising candidate to delay this process. But also why for example centenarians probably live a longer life.

2⃣ The hyperfunction theory also fits well with my current mindset and the theory was like a big missing puzzle piece that I found. I feel thanks to this that my overall work with my own longevity journey will improve a lot. The theory will not often give detailed answers on specific cases but I think it will help me in guiding me in the right general direction in different cases.

3⃣ It was interesting to get Mikhail’s view on the glucose regulating drug Acarbose and that he personally prefers a low carb diet when combining it with Rapamycin. I’m already satisfied with the levels of carbs in my diet that I eat today. It’s not a high carb diet or a ketogenic diet but something in the middle. So things point more and more to the fact that I will try to add Acarbose to my longevity stack at the beginning of next year. I don't want to decide yet what I will do so I will keep the door open for other alternatives until January when I do some kind of improvement to my longevity protocol.

We were all shocked when Mikhail recently revealed that he was diagnosed with lung cancer which had spread to his brain. What he is now dedicating his life to really shows what unique person he is. He is now using his passion, knowledge and his great mind to develop a new form of treatment to cure his cancer. This is his life mission now and this is something he will share with us in the future. May the force be with you, my friend 🙏

PS Link to the epic podcast in my bio. I can highly recommend the youtube version with the bonus slides.

[Charles Nelson @_Biohacking]

@KristerKauppi Thanks for the rebound effect info., Krister!
Very interesting.

[Charles Nelson @_Biohacking]

@bioiq @bryan_johnson @WHOOP Thanks Noah!

[Charles Nelson @_Biohacking]

100% sleep performance streak, 1st month complete ✅
@bryan_johnson

data via @WHOOP

[Charles Nelson @_Biohacking]

@KristerKauppi Yes!
- The “Hyperfunction theory of Aging”.

- Concept of Rapamycin/Rebound effect.

- The fact that he likes the combination of #Rapamycin, exercise and a high animal protein + ketogenic low carb diet.

I take 10mg/weekly and have that routine as well.