Meng Yue

Biologist @karolinskainst / Alumni @MBIsg @Kanchanawonglab #celljunctions #mitosis #catenins #morphogenesis #epithelial #microscopy #polarity

[Cornelia Schwayer @CSchwayer]

Excited to share that our work on ‘How the gut gets patterned during regeneration’ is out now 🤩 https://t.co/dT6cnhY1lS
Thanks a lot to @priscaliberali @Silvia_Bar01 @d_brueckner @EdouardHannezo and all co-authors! ��

[The Clevers Lab @TheCleversLab]

1/4 Gut renewal is not passive “crowd control.” Instead of being pushed out by crowding or dying from apoptosis, cells compete in a mechanical tug-of-war. Weaker cells are eliminated—reframing intestinal homeostasis as a force-regulated process. https://t.co/y17pTHBkuj

[Prof. Nikolai Slavov @slavov_n]

Mechanotransduction in the nucleus

Multiple TFs transmit mechanical forces into transcriptional regulation.

Nuclear shape, size, and chromatin abnormalities are common features of many diseases.

[Esteban Hoijman @EstebanHoijman]

How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos.
https://t.co/ozYCyQ6udP

[Blake Hernandez @loxstoplox]

I’m excited, relieved, and honored to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @ScienceMagazine ! (link at end of 🧵)

[Kashish Jain @kashish195]

🚀Exciting new review exploring the intersection of #mechanobiology & #AI!
From predicting cell forces to analyzing complex genomic data, AI is unlocking new insights into how cells respond to mechanical cues.
https://t.co/MlgGCRe7AZ

[Meng Yue @_mengyue]

lab new work!

[Tony Kanchanawong @KanchanawongLab]

We've developed Vortex Interference Localization Microscopy (VILM) – a new interferometric super-resolution method that streamlines 4Pi single-molecule imaging using a much simpler setup! 🔬
🧵👇 (1/4) #Microscopy #SuperResolution #SMLM #Bioimaging

[Mechanobiology Institute @MBIsg]

Our heartfelt condolences to Linda and all affected by this devastating news. Prof Michael Sheetz was an inspirational Founding Director of MBI and we would not be here today without his foresight and leadership. We hope to continue his legacy in mechanobiology for years to come.

[Gottardi Lab @GottardiLab]

AT LONG LAST… The essential #adherensjunction mechanosensitive protein alpha-catenin is required for #cytokinesis fidelity. We credential a previously defined (but poorly understood) abscission factor in this process, LZTS2. 🧵1/12 https://t.co/tUicleRZ4M

[Daniele Fachinetti @FachinettiLab]

#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape and mechanics to guarantee genome integrity
https://t.co/npMBatW69k. Great work from @sol_herve and Andrea Scelfo in close collaboration with @KateMiro1.

[Meng Yue @_mengyue]

@EpiMechFC The old school hand written so good!

[Meng Yue @_mengyue]

a memorable experience in @HHMIJanelia 🫶🏻

[Janelia Conferences @janeliaconf]

A big “thank you” to everyone who joined us this week @HHMIJanelia to share their outstanding science and connect with colleagues in cellular polarity research.

[Ben Goult @bengoult]

"Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction" Nice paper from Cristina Bertocchi and Andrea Ravasio at @ucatolica and @MBIsg https://t.co/JYCEEWO3mR @LivUniISMIB

[Luisma Escudero @lmescu]

Our new paper is published today on @Dev_journal!!!!
A collaboration with @DeirdreLyonsPhD and @Vane_Barone where we use sea star embryos to analyse the 3D packing dynamics and, of course, #sctuoids. This is the Thesis work of @aj_tagua.

https://t.co/QvJa3p9xhN

[Meng Yue @_mengyue]

Mood of epithelial cells! #cellbiology #epithelial

[Journal of Cell Biology @JCellBiol]

The cadherin–catenin linkage has been considered the keystone of junctional force transmission, but new findings challenge this paradigm. Sebbagh @univamu and Schwartz @YaleMed discuss new research in this Viewpoint: https://t.co/uN1t7vdSli

[epithelial mechanics fan club @EpiMechFC]

Engl, W., Arasi, B., Yap, L. L., Thiery, J. P., & Viasnoff, V. (2014). Actin dynamics modulate mechanosensitive immobilization of E-cadherin at adherens junctions. Nature Cell Biology, 16(6), 584–591. #EpithelialMechanics https://t.co/LweeT1tfaH

[Meng Yue @_mengyue]

@HJRBio Catch the trends

[Meng Yue @_mengyue]

despite all the discussion in comments, this might be the gap from me with scientist, all I see is a giant hashbrown!

[Andy Moore @aaandmoore]

A 10× expanded nucleus stained with Hoechst to label DNA. At this expansion factor you can see gaps in the surface staining. Nuclear pores?

[epithelial mechanics fan club @EpiMechFC]

New Year's party is around the corner! 🎉 Let's talk about a party—where drugs don't hit the dance floor but tune #EpithelialMechanics by hitting actomyosin cortex! 🧬💊

Here's our guide to doing drugs 🧵