Sameer Aryal

Molecular mechanisms of neuropsychiatric disorders @broadinstitute.

[bioRxiv Neuroscience @biorxiv_neursci]

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and ... https://t.co/n7CkEZdYZ0 #biorxiv_neursci

[Bryan Song @bryanjsong]

Akap11 mutations greatly increase risk for #bipolar disorder and #schizophrenia. Not much was known about this gene when we started. Here’s what we learned!

https://t.co/nCeX4r8ucA

Thanks to Morgan Sheng, @ajgrange, Yang Ge, Borislav Dejanovic & crew @broadinstitute

[Francesco Longo @fran_longo17]

Excited to share that our paper on cell-type specific changes in the striatal medium spiny neurons underlying the expression of RRBs in FXS mice is finally online @CellReports. Thanks to team members from @KlannLab, @CarterAG, @NicTritsch, and @BagniLab for their contribution!1/6

[Sameer Aryal @_sameeraryal]

@fran_longo17 @CellReports @KlannLab @CarterAG @NicTritsch @BagniLab Congratulations @fran_longo17 ! Ad maiora semper!

[Ben Hobson @BenHobs3]

Nat Biotech recently published a provocative study claiming single synapse RNA-seq. Unfortunately, there is no evidence demonstrating droplet-based sequencing of single synaptosomes. They are likely studying random pieces of cellular debris. Our reply:

https://t.co/QyXql1AXt2

[LabAnimal @LA_NatRes]

🧵4/4
@_sameeraryal shows shared molecular changes in schizophrenia and bipolar disorder, offering new possibilities for understanding and treating these disorders!#MentalHealth #Schizophrenia #BipolarDisorder 🧠💡

👉 https://t.co/MLRzdvUSQU

[Sameer Aryal @_sameeraryal]

@Mauricio_Neuro Congratulations Mauricio!

[Broad Institute @broadinstitute]

A deep, unbiased analysis of synapse proteins in brain tissue from individuals with schizophrenia, those with bipolar disorder, and unaffected individuals uncovers molecular evidence that these disorders have more in common than previously thought. https://t.co/xaYVcXsewF

[Sameer Aryal @_sameeraryal]

@fran_longo17 @CellReports Many thanks Francesco!

[Sameer Aryal @_sameeraryal]

Pleased to note that this study is now published in the open-access journal @CellReports!

[Sameer Aryal @_sameeraryal]

We carried out proteomics of synaptic fractions purified from the DLPFC of humans with schizophrenia and bipolar disorder. We found multiple interesting changes, some of which were also seen in mice lacking Akap11, a shared risk gene for both diseases. Happy to share the work!

[Sameer Aryal @_sameeraryal]

@PrabhatSKunwar @CellReports Thanks very much for the kind words!

[Sameer Aryal @_sameeraryal]

@prerana123 @CellReports Thank you so much! Hope all is well!

[Sameer Aryal @_sameeraryal]

https://t.co/18dxcGL932

[Cell Reports @CellReports]

Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model https://t.co/4kQI0r375w

[Sameer Aryal @_sameeraryal]

@Mauricio_Neuro Anadolu, Sossin (2022) has sequencing data from biochemically purified mRNP granules (P5 brains). https://t.co/5Sokkseioh

[Sameer Aryal @_sameeraryal]

@Mauricio_Neuro For biochemical enrichment from brain tissue, the approach described by El Fatimy (2016) and Aschrafi (2005) may be useful. See https://t.co/FDAS1o7ysW

[Sameer Aryal @_sameeraryal]

@fran_longo17 Thanks very much Francesco!

[Sameer Aryal @_sameeraryal]

Happy to share two recent studies I contributed to. The first led by @fran_longo17 found that cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice.

[Francesco Longo @fran_longo17]

Excited to share our last work from @KlannLab where we unveiled cell-type specific changes in the striatal medium spiny neurons underlying the expression of RRBs in FXS mice! A great collaboration with @CarterAG, @NicTritsch, and @BagniClaudia labs! 1/5

[Sameer Aryal @_sameeraryal]

@prerana123 Thank you! It’s great to see these studies out.

[Sameer Aryal @_sameeraryal]

@fran_longo17 @KlannLab @CarterAG @NicTritsch @BagniClaudia Congratulations @fran_longo17 !