AbdulAbdul

@TriIMDPhD @junyue_cao lab @RockefellerUniv @WeillCornell (views are my own) Previously @broadinstitute @RutgersU-B.A

[AbdulAbdul @Abdul_Squared]

Spatial genomics has existed for many years, but it has often been limited by complex imaging systems, specialized equipment, and $$$.

With IRISeq, we wanted to simplify this to a simple PCR rxn. https://t.co/jmS3N6PRu2

[Junyue @junyue_cao]

Our paper is officially out in @NatureComms today https://t.co/agenNa0A8k Congrats to @xu_zxu and Aileen from the lab!

[MIT Picower Institute @MIT_Picower]

We are heartbroken to have lost our founder, who provided so much inspiration, but we are all honored to carry on the science he loved so much. https://t.co/IR7QX8g0Q0 #neuroscience #biology

[Santosh Vardhana @SantoshVardhana]

I couldn’t be prouder to announce that @tanmana_mitra’s thesis work identifying how metabolic demand drives terminal T cell exhaustion is out today in @ImmunityCP : https://t.co/KyE1YTarXp

[Ruslan Rust @rust_ruslan]

Wow such cool work: A human developmental and adult brain atlas benchmarks dopaminergic stem cell models and cell therapy candidates

https://t.co/vutPOijWKW

[Ishmail Abdus-Saboor @IshmailSaboor]

Congrats @JasonSynaptic and team! Stunning and easy to understand results, which is becoming more rare these days in neuroscience.

[Jean-Rémi King @JeanRemiKing]

We’re happy to announce 2 releases today:
- 🧠Brain2qwerty v1 is published at @NatureNeuro
- 🚀 Brain2Qwerty v2 is now publicly released

Explore how we decode sentences from non-invasive brain recordings: https://t.co/IdR6gK2hcd

Links:
📄v1 Nature Neuro: https://t.co/wnRjc9W9gI
📑v2 Meta preprint: https://t.co/oSfLOQFcvg
💻Code: https://t.co/Xbe0XWfWQL
📊Data: https://t.co/SCBbs4AhTg
📝Blog: https://t.co/15RvsAaXlH
🧵Thread: https://t.co/d8FJrVyDut

[Ro Khanna @RoKhanna]

GPS in 1980s, Human Genome Project, CRISPR at Berkley funded through NIH, mRNA, expanded and early Head Start...

[Josh Welch @LabWelch]

Our CytoSignal paper is now published in @NatureGenet! During revision, we generated a one-of-a-kind dataset with direct measurements of ligand-receptor protein interactions in situ in the mouse embryo, along with Visium HD spatial transcriptomics. https://t.co/UmzcIdZwfp

[Sherif Gerges @SherifMorris]

I’m delighted to finally share work from my PhD with @dalygene and @s_mccarroll.

We show how human genetics and AlphaFold3-predicted protein structure can be combined to discover new mechanisms underlying missense risk in brain disorders.

1/n

https://t.co/slc7xgCMHV

[Joshua Weinstein @jaweinst]

Delighted to share our new preprint on xVDM (cross-linked volumetric DNA microscopy), turning the protein scaffolds inside intact tissue into dense, DNA-encoded proximity networks for transcriptome and protein mapping.
https://t.co/ke51NqDmwe

[AbdulAbdul @Abdul_Squared]

@jaweinst @RongFan8 Inspiring @jaweinst !

[Dan Landau @landau_lab]

Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

[AbdulAbdul @Abdul_Squared]

Congrats @xu_zxu and Aileen on this amazing work!

[Zihan Xu @xu_zxu]

Thank you so much Jun! This was a great team effort with the brilliant but Twitterless Aileen, an MD-PhD student in the @junyue_cao Lab. It has been such a privilege to work with everyone in the lab and to call @RockefellerUniv my PhD home.

[Junyue @junyue_cao]

New preprint alert! 🚀 Across 60 human cancer cell lines spanning 20 cancer types, single-cell RNA+ATAC reveals pan-cancer cell-state heterogeneity, core gene-regulatory networks, and an EMT axis conserved across tissue origins.

Huge congrats to first author @xu_zxu, who recently defended his PhD, and Aileen Ugurbil from our lab @RockefellerUniv! https://t.co/4fNQJlJY3m

[Junyue @junyue_cao]

New preprint alert🚀 Using TrackerSci, we quantified the birth rate of each cell type across the whole organism, and how these rates are rewired with age.

Huge congrats to the incredible Dr. Lu @ziyu__lu from @RockefellerUniv, who just defended today!
https://t.co/h50Swm03Lh

[Bo Wang @BoWang87]

Today at #ASCO26, more results about the newest clinical trial of daraxonrasib: In the Phase III RASolute-302 trial, a once-daily RAS(ON) inhibitor nearly doubled median overall survival (13.2 vs 6.7 months) and reduced the risk of death by ~60% versus chemotherapy in previously treated metastatic pancreatic cancer.

KRAS was once considered “undruggable.” This is what persistence in science looks like.

A landmark moment for targeted therapy and for patients who desperately need better options. #CancerResearch #PancreaticCancer

[Eric Topol @EricTopol]

There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines
https://t.co/e04jqJMPw0

[Eric Topol @EricTopol]

Cardiac "remuscularization" for treating severe heart failure with patched heart muscle derived from stem cells (a biological ventricular assist device) successful in 12 of 20 patients @NEJM
https://t.co/mAwgj2rAwE https://t.co/3ogxaJFDE0

[thmonk @thmonk_pf]

lymphocyteが脳老化に於る炎症と脳室恒常性を制御

IRISeqは光学撮像不要のビーズ間配列決定で脳組織を空間的にprofiling

老齢mouse脳で脳室IFN炎症をlymphocyteが駆動しlymphocyte欠損が上衣細胞を保護する新機序を解明

OA
#aging
#immunology
#papers
https://t.co/fZ2OYSsuta

[Ishmail Abdus-Saboor @IshmailSaboor]

Long-term editing of brain circuits with engineered electrical synapses! I still remember years ago when @KafuiDzirasa from @DukeU @hhmi_science called me beaming with excitement about this new technology. Here it is today @Nature.

https://t.co/5fnW6zW0z6