Serini Lab

Our lab tries to grasp the molecular mechanisms by which cells adhere to and move through the body environment in cancer, vascular and rare genetic diseases

[Serini Lab @adhynamic]

Glad to share our last manuscript on a luminescent sensor we created to unveil novel potentially actionable regulators of β1 integrin activation in vascular endothelial cells and angiogenesis. Great collab w/ Jieqing Zhu Lab @VersitiResearch @ZanivanLab https://t.co/vBfutpQZ2N

[Cell Reports @CellReports]

Mechanobiological mechanism of cyclic stretch-induced cell columnarization https://t.co/uV4ZFelXPM

[The EMBO Journal @embojournal]

Local weakening of cell-extracellular matrix adhesion triggers basal epithelial tissue folding
Andrea Valencia-Expósito, María Martín-Bermudo et al
https://t.co/hmQtcKqff3

[Serini Lab @adhynamic]

@paoloarmando83 @VersitiResearch @ZanivanLab Thank you Paolo!

[Serini Lab @adhynamic]

Glad to share our last manuscript on a luminescent sensor we created to unveil novel potentially actionable regulators of β1 integrin activation in vascular endothelial cells and angiogenesis. Great collab w/ Jieqing Zhu Lab @VersitiResearch @ZanivanLab https://t.co/vBfutpQZ2N

[Ben Goult @bengoult]

September issue of @JCellBiol also contains our new paper on TLNRD1 (talin rod domain containing 1) protein and its role in the Cerebral Cavernous Malformation complex. https://t.co/hlfeSFVsjn @guijacquemet @LivUniISMIB @biokent @UniTurku

[Enrico Giraudo @GiraudoEnrico]

Our paper is now out!! Great and exciting collaborative work. Thank you all.
PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination
https://t.co/GmQDJZpQuL

[Ben Goult @bengoult]

We just updated our preprint, "The structure of an Amyloid Precursor Protein/talin complex indicates a mechanical basis of Alzheimer's Disease" to include beautiful new proximity ligation data of talin and APP in neurons. 😍 @jcl_lambert @LivUniISMIB https://t.co/beJiZHaFm6

[Cell @CellCellPress]

Now online! Ligand binding initiates single-molecule integrin conformational activation https://t.co/WTRxBTVTQs

[Cell Biology J-Club @cell_club]

Rab7 deficiency induces lysosome formation from recycling endosomes leading to an increased degradation of cell surface proteins https://t.co/lMuIkmkZwQ

[Paolo Armando Gagliardi @paoloarmando83]

Check out our latest review in which we discuss the recent exciting discoveries on single-cell and collective ERK signaling dynamics!

[eriksahailab @eriksahailab]

Very pleased to share our latest preprint on MAPK dynamics and cell fate decisions in lung cancer https://t.co/nGnBprWi8m . Does EGFR mutation mean MAPK is always on? NO, it shows dramatic pulses👇1/4

[Jacky GOETZ @GoetzJacky]

💥Check out our latest work just out @NatureComms
🔬#Platelets shape the outgrowth of #metastasis, even growing & established foci.
🎯We further identified #targets and tools with therapeutic potential
https://t.co/5mIhLvcJI8
#mouse #zebrafish #imaging #Immunology #hemostasis

[Giorgio Seano @GiorgioSeano]

Thrilled to announce our latest research just published in @NatureComms! We investigated how therapy induces therapy resistance via cell state transition and vessel co-option in glioblastoma. (1/11) https://t.co/ek1HdLCBg3 #GBM #btsm #Research

[Ishier Raote @ishier_raote]

Our latest paper! A promising avenue for therapeutic intervention in fibroses, characterized by excessive ECM production, via targeted inhibition of TANGO1-mediated ER export.
TANGO1 inhibitors reduce collagen secretion and limit tissue scarring
https://t.co/BRx36aVhfF

[Sara Zanivan @ZanivanLab]

Thrilled to see our latest work “Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function” led by Alice Santi and @emilyjkay1 on the cover of @scisignal.
Beautiful images by @BairBeatson
Paper here 👇🏻 https://t.co/Vs2Dj2ByQM

[Guido Serini @gserini]

Looking very much forward to my visit to @CIBIO_UniTrento of Thu July 20th, meeting and discussing with its scientists

[CIBIO - UniTrento @CIBIO_UniTrento]

We are glad to host "In search of normality: looking for molecular strategies to repair #cancer blood vessels" a seminar by @gserini

🗓️ July, 20th at 2.30pm
🏛️ Room A104, Povo 1
ℹ️ https://t.co/H7kNfkzlTp

#blood #bloodtumor

[Johanna Ivaska @johannaivaska]

Interested in a Post-doc @IvaskaLab @BioscienceTurku working on novel anti-invasive barriers in BrCa - cutting edge cell biology/imaging/HTS/clinical collaboration? Watch this space! We will be shortly opening a call a post-doc @WorldwideCancer granted 3 year funding

[EMBO Mol. Medicine @EmboMolMed]

Online today! 👉Mutated #AxonGuidance gene #PLXNB2 sustains growth and invasiveness of stem cells isolated from #CancerOfUnknownPrimary

By @GiraudoEnrico, L. Tamagnone & colleagues
@fpoirccs @unito @Unicatt

🗞️Read #openaccess: https://t.co/eLAOnoiAXu

[Enrico Giraudo @GiraudoEnrico]

Our paper is now out!! Great and exciting collaborative work. Thank you all.
https://t.co/0l8tNow4YP