Alexandros Drainas

Group Leader @BioMed_X - Team EDC

[Alexandros Drainas @alexdrainas]

How do cancer cells grow and organize themselves within a tumor??? See thread.
https://t.co/1UDLQzEo5w

[International Space Station @Space_Station]

The Exp 71 crew soared into the Moon’s shadow during the solar eclipse on Monday afternoon while working on cargo transfers, spacesuits, and science. More... https://t.co/8LXGHC95XO

[Sasha Gusev @SashaGusevPosts]

I highly recommend anyone working with single-cell data read this and take these issues seriously. These tools are under active development, which is terrific and to be applauded, but has also created a very fractured methods ecosystem. 1/

[Julien Sage @SageJulien]

Excited to see DISCO coming out of stealth mode! Initially with Roman Thomas, @JHeuckmann, and @bwollsch, now with many others! https://t.co/gRB2LmIGWs

[Gorjana @gorjanarackov]

There is an open postdoc position in my team ⬇️⬇️⬇️

If you did multi-color #flowcytometry during your PhD and your interested in doing science at the interphase between academia and industry check it out:

https://t.co/0WbBTDa2i3

[Julien Sage @SageJulien]

Excited to share the work of @kojulieh @CR_AACR https://t.co/WZnKKgbFZ7. Data from mice and humans show that the NFIB transcription is a strong promoter of SCLC progression and metastasis. But is NFIB required for metastasis? Julie's work indicates it's not the case.

[EMBL @embl]

Antimicrobial resistance is a major emerging global threat, and novel drug combinations are a promising approach for countering it.

In a new study, EMBL scientists have profiled 10,000+ drug combinations for their effect on key gram-positive bacteria.

https://t.co/xdEjbIQ95M

[Basem Al-Shayeb, Ph.D. 🧬 @themicrobeguy]

🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n)

https://t.co/zA4EyAVHFQ

[Noah F. Greenwald @NoahGreenwald]

The second annual Spatial Biology Workshop is just two weeks away! This free event will showcase the power of spatial techniques to answer biological questions. We'll be showcasing new methods for data generation and analysis, as well as the novel findings they enable (1/x)

[King L Hung @kinglhung]

Cancer-driving genes are often encoded by extrachromosomal DNA circles (ecDNA), which segregate unequally during cell division and lead to tumor heterogeneity. Our new paper shows that distinct ecDNAs can be inherited together by dividing cancer cells. 1/

https://t.co/t5Q5mFEbdl

[Sizun Jiang @SizunJ]

Hot out of the PRESS: ExPRESSO☕️🗜️: Physical expansion of FFPE tissues (or cells) for spatial proteomics!

It works under VACUUM‼️: extending hydrogels to mass spectrometry imaging!

Amazing work of the new Dr. Yunhao Bai, with Bokai, @xavi_r_c , and the bossman @GarryPNolan

[Andrea Ventura @aventura71]

Our latest work on engineering extrachromosomal circular DNAs (ecDNAs) is now available in @biorxiv.
In this preprint we describe a novel strategy to engineer the formation of large (>1 Mb), multigenic, amplifications mediated by ecDNAs in cells and mice.
https://t.co/lul4tAWXjL

[Jens Luebeck @Jens_Luebeck]

So when does ecDNA arise, exactly?

Our study on #ecDNA and the transformation of pre-cancerous Barrett’s esophagus into cancer is out today. This collaboration brought together @Team_eDyNAmiC, @RFitzgerald_lab and the @FredHutch Seattle Barrett’s Study.🧵
https://t.co/TbDNCl4LJV

[Alexandros Drainas @alexdrainas]

Check out my Tools of the Trade article https://t.co/r0iH1oXxZK on EpicMIBI. Many thanks again to all authors to contributing to investigating intratumoral heterogeneity in cancer with EpicMIBI. @NatureRevCancer @SpringerNature

[Ruxandra Lambuta @RuxandraLambuta]

Still recovering from a whirlwind week! Firstly, I'm exceedingly happy that my first first-author paper which tackles how whole genome doubling events affect 3D organisation of the chromatin in the context of tumour development came out in @Nature https://t.co/5H6OSgSN6S.

[d@x @groktheworm]

I'm speechless.

Not peer-reviewed yet but a submitted paper.

The 'presented images' were shown to a group of humans. The 'reconstructed images' were the result of an fMRI output to Stable Diffusion.

In other words, #stablediffusion literally read people's minds.

Source 👇

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

🔈🔈🔈For all of those who’ve been following, here’s the new Junior Group Leader announcement for @IRBBarcelona !!!
Broad search in age-related diseases (which is almost all diseases).

APPPY NOW!!! 🙌🏼🙌🏼🙌🏼

https://t.co/m6rWHmlKIB

[Nikos Vakirlis @vakirlis]

First time I'm asking this, a retweet would be greatly appreciated!

I'm looking for fresh or soon-to-be PhDs interested in applying for an EMBO postdoc fellowship to work on genetic novelty (and more) based in Greece. The odds should be in their favor 👇

[Hersh Bhargava @HershBhargava]

Following the life science literature is hard. Unhappy with existing tools, I built a small, #opensource tool that instantly creates Pubmed RSS feeds from Google Sheets with author/journal/keyword info. Check out my workflow using Pubmed-Sieve!
https://t.co/3JqyOWKOLW

[Gerlich Lab @Gerlich_Lab]

Pleased to introduce our latest preprint, out now: “Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase”. We present new quantitative assays probing the conformation of replicated chromosomes by imaging and high-throughput DNA sequencing. A tweetorial:
1/9

[Eric Topol @EricTopol]

"These data demonstrate that MVA-S vaccination confers a complete protection against #SARSCoV2 brain infection and the associated neuropathological damage (neuronal loss and vascular damage), even after a second viral infection."
https://t.co/rHzB2Yu4hD
@NatureNeuro @ibis_sevilla