Alexandra Pike

Visiting Assistant Professor @OberlinCollege
🧬 DNA replication, biochemistry, telomeres, naps 👩‍🔬 she/her

[Alexandra Pike @amimspike]

And now officially published @NAR_Open 🎉

Now with some more experiments with Pol alpha...I'm looking forward to following up on these findings in the near future 😊

https://t.co/zjNPAvyylD

[Alexandra Pike @amimspike]

In our recent preprint, we tested the requirements for the ssDNA-binding protein RPA in different stages of eukaryotic DNA replication…
https://t.co/jtf351v7cw

[Rajini Rao @madamscientist]

BREAKING: Johns Hopkins along with 12 peer institutions and Assoc of Amer Univ sues to stop drastic cuts in NIH funding. This is separate from lawsuit brought by 22 states, which also includes Maryland. Hopkins prez cites our 600 clinical trials that would be crippled by the cut.

[Alexandra Pike @amimspike]

Also I cannot imagine that this order requires $25 of ice, considering that I literally have to boil the RNaseA before using it, and gel red is stored at room temp.

[Alexandra Pike @amimspike]

Absolutely shocked that for an order containing 2 tubes of Gel Red and 1 RNaseA powder, @MilliporeSigma is charging us $61.69 in shipping plus $25 in ice. In what world???

[Alexandra Pike @amimspike]

Our resource coordinator said we haven't been able to negotiate better shipping costs with Sigma. But there is no way this is reasonable, right?

[JK Nandakumar lab @LabNandakumar]

Our Spotlight on beautiful work from the de Lange (@SarahWCai et al), Walz, and Cech labs.

At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery: Molecular Cell https://t.co/Or4tsqYYFP

[Alexandra Pike @amimspike]

Also considering I've only used AKTA before, but my department is looking to replace an end-of-life BioRad one (so misc parts/components are already here)

[Alexandra Pike @amimspike]

I know yall biochemists have strong opinions about things....how do you feel about AKTA vs BioRad for FPLCs? Performance, user interface, maintenance, etc.

[Rebecca Keener @RebeccaKeener9]

Very excited that my meta-analysis of telomere length GWAS and experimental validation showing that POP5 and KBTBD6 are human telomere length regulation genes is out in @NatureComms!
Shout out to my mentors @alexisjbattle and @RasikaMathias
https://t.co/R9UvSVtmxs

[Alexandra Pike @amimspike]

@RebeccaKeener9 @NatureComms @alexisjbattle @RasikaMathias Congrats Becca!!!!

[plasmidsaurus @plasmidsaurus]

Plasmidsaurus reveals the spooky things lurking in your sequences...

[Irina Bezsonova @IrinaBezsonova]

Day 11/31 of #inktober2023

Prompt: WANDER

Yellow Fluorescent Protein (Pdb: 1YFP).
It lights up and lets us see how proteins wander through the cell.

Next prompt is SPICEY.
Please send suggestions.

@PDBeurope @buildmodels @inktober #sciart

[Alexandra Pike @amimspike]

@ProfessorAntony I know someone who is starting a lab and looking for a tech for the spring --https://t.co/Y6tEtddYIh

[The Nobel Prize @NobelPrize]

The discoveries by Katalin Karikó and Drew Weissman – awarded the 2023 #NobelPrize in Physiology or Medicine – were critical for developing effective mRNA vaccines against COVID-19 during the pandemic that began in early 2020.

Through their groundbreaking findings, this year’s laureates have fundamentally changed our understanding of how mRNA interacts with our immune system. They have contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times.

[Alexandra Pike @amimspike]

@LabNandakumar @NAR_Open Thanks JK!

[Alexandra Pike @amimspike]

And now officially published @NAR_Open 🎉

Now with some more experiments with Pol alpha...I'm looking forward to following up on these findings in the near future 😊

https://t.co/zjNPAvyylD

[Alexandra Pike @amimspike]

In our recent preprint, we tested the requirements for the ssDNA-binding protein RPA in different stages of eukaryotic DNA replication…
https://t.co/jtf351v7cw

[Alexandra Pike @amimspike]

@GregDodge9 Good Kiwi

[Alexandra Pike @amimspike]

Chaotic evil: someone left a permanent marker on the whiteboard tray in the classroom I was using this morning

[Alexandra Pike @amimspike]

When it's the first day of class AND you get a "Manuscript Accepted" email 🎉

SO MANY FEELS

[JK Nandakumar lab @LabNandakumar]

What a pleasant surprise! PDBe featured our recently published structure of human POT1 bound to the telomeric ds-ss junction. See 👇 thread for more details of our study. https://t.co/yLioLJWv2c

[Alexandra Pike @amimspike]

@ZHallberg Might be possible - look up the manual for the Sera-Mag Select beads and the "right-sided size selection" which helps you select for the smaller DNAs!