JK Nandakumar lab

Professor @UMich_MCDB dept of @umichLSA College at the University of Michigan (@umich) Views/posts are JK's

[HHMI @hhmi_science]

Beyond thrilled to welcome our inaugural cohort of #CechFellows — 176 talented undergrads who will spend 9 weeks this summer contributing to real scientific discovery alongside leading HHMI scientists across the country, & at our Janelia Research Campus! https://t.co/LJcc6tjHbH

[U-M College of LSA @umichLSA]

For undergrad students, a single summer of research can be transformative.

The @UMich_MCDB's Horizons Summer Research Internship Program is dedicated to expanding opportunities for students: https://t.co/0sr8a0UzBG

[Samrat Mukhopadhyay @SamratLabMohali]

Happy to share our community note published in Nature Communications. In this 14-page article (34 authors from 9 countries), we discuss current practices in biomolecular phase separation and hope it will be useful to the biomolecular condensate community.
https://t.co/UgwnvPpOk2

[maria g castro @castro2355_mg]

MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB) https://t.co/JX56MFhV0P

[Bing Ye @byneuron]

Tenure-track assistant professor position in neuroscience or physiology at University of Michigan LSA Molecular, Cellular, and Developmental Biology (MCDB) https://t.co/T6zxidYd9p

[Simanshu Dhirendra @simanshu]

BBO-10203 is currently being evaluated in the Phase 1 BREAKER-101 trial (NCT06625775) in patients with HER2+ and HR+/HER2- breast cancer, KRAS mutant colorectal cancer, and KRAS mutant non-small cell lung cancer.

[Simanshu Dhirendra @simanshu]

This publication describes how BBO-10203 disrupts the RAS–PI3Kα interaction without impairing insulin signaling, resulting in broad antitumor activity across multiple cancer models. It also shows enhanced efficacy in combination with other targeted agents.

[Simanshu Dhirendra @simanshu]

We are excited to share our collaborative work on the first-in-class RAS:PI3Kα breaker, BBO-10203, which has now been published online in @ScienceMagazine !

🔗 Read the full article here: https://t.co/pUvLXbdXJp

BridgeBio Oncology Therapeutics (BBOT) @FredNatLab @Livermore_Lab

[JK Nandakumar lab @LabNandakumar]

@MGodinhoFerr Congratulations, Miguel!

[Miguel Godinho Ferreira @MGodinhoFerr]

Happy to share our new paper! 🎉
We show that #cGAS–#STING inflammation drives premature #aging in response to telomere shortening in #zebrafish.
🧬 Telomere-driven aging occurs in 2 stages:
1️⃣ Senescence, inflammaging, cancer
2️⃣ Genome instability, death

https://t.co/Dwr2klwgNY

[Ming Li Lab@Umich @MingLi_Umich]

New paper from the lab. We collaborated with the legendary Stuart Kornfeld lab to study the molecular mechanisms of how TMEM251/LYSET regulates the M6P pathway.

Molecular Insights into the Regulation of GNPTAB by TMEM251 https://t.co/rlQbZBZTuw

[Simanshu Dhirendra @simanshu]

Our structural-guided insights contributed to the design of BBO-8520, a first-in-class dual inhibitor targeting both GTP-bound (ON) and GDP-bound (OFF) KRAS G12C.
Excited to see this work now published in @CD_AACR! @FredNatLab @BridgeBioPharma

[Kelly Nguyen @KellyTHD_Nguyen]

Last week, we said farewell to the first postdoc of our lab, George Ghanim @AutomneNine who will start his own lab at Princeton in 2025. We are proud of you and thankful for all your contributions. Please watch out for exciting future opportunities from the Ghanim lab!

[Miguel Godinho Ferreira @MGodinhoFerr]

“We highlight the differences between human and mouse telomere biology that may contribute to discrepancies between human diseases and mouse models. Finally, we discuss recent efforts to generate new ‘humanized’ mouse models to better model human telomere biology.” 👇

[Nils Walter Lab @NilsWalterLab]

In @ScienceMagazine - great collaborative work w/ @AlbertW_Lab & @RappsilberLab showing that bacterial RNA polymerase can thread nascent mRNA into the pioneering ribosome from two sides for higher translation initiation efficiency - target for antibiotics?
https://t.co/r6jLzkFjOO

[Abhishek Chatterjee @AChemSynBio]

Happy to share Elise and Tarah’s work on building a facile selection system to engineer E. coli leucyl synthetase for site-specific incorporation of many new noncanonical amino acids into proteins in eukaryotes, including ornithine and N-acetyl-methyllysine!

[MCDB Michigan @UMich_MCDB]

MCDB's Kozik Honored by Microbiology Society | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB) https://t.co/fHCrYexCOH

[Molecular Cell @MolecularCell]

In our #RNA focus issue, we invited viewpoints from three groups on the controversy over PRC2-RNA interactions and asked how they might reconcile the findings on the topic. https://t.co/grONxTaM9U https://t.co/gWDlXWOzjt https://t.co/8GyMS3LXKg

[Cornell University @Cornell]

Ratan Tata ’59, B.Arch. ’62, the university’s most generous international donor and one of India's most respected business leaders and philanthropists, passed Oct. 9. We will remember his legacy of transformative giving to Cornell.

https://t.co/0v0zYb6aGl

[Ci Ji Lim @cijilim]

1/8 ❄️🔬Excited to share our latest work published in @NatureComms! Led by @kaitlyn_m_abe and in colab with @GrantCryoEMLab, we've discovered a simple, cost-effective way to mitigate sample damage at the air-water interface during grid preparation. #CryoEM https://t.co/4Iui3Ita1k