Interested in exploiting genetic dependencies for the treatment of cancer? We are looking for collaboration partners! The call is still open until 12th September 2023.
https://t.co/1wzMt5csm1
@yogeshgoyallab @arjunrajlab@Nature@pennbioeng@NorthwesternU Very interesting read! Lentivirus will have a preference for inserting itself into open/active regions of the genome. Did you look at the insertion sites of the barcodes and how these may contribute to the "predestined resistant fate" of a given clone? @arjunrajlab
We are looking for collaboration partners! Please submit your proposals for promising tumor-specific genetic dependencies here: https://t.co/1wzMt5csm1
Deadline extended! You still have a few days to register for the 1st European Cancer Dependency Map Symposium organized by HT @emblebi@sangerinstitute@ETH_en on cutting-edge research on #cancer vulnerabilities and therapeutic targets.
👉 https://t.co/SR0U0jzXyC
New paper with @idmehta@naar_k@David_J_Adams in @trendscancer. We review methods for identifying synthetic lethal interactions between paralogs in cancer and discuss some of the challenges of exploiting them for the development of targeted therapeutics
https://t.co/yBcSvKJjnA
Looking for a Research Laboratory Scientist to join our team @Boehringer (Vienna, Austria). Target identification. Cancer drug discovery. Great work environment. Please apply via https://t.co/PUinJxlBPb (and spread the word)
Happy to share! ARTi - a new method for highly stringent target validation overcoming limitations of traditional RNAi and CRISPR. Big thanks to @johannes_zuber for a fantastic collaboration!
Precision RNAi using synthetic shRNAmir target sites https://t.co/6ZzIKNvENX
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling. https://t.co/aOxmVngyo3 Thanks to a fantastic team! #teamscience#Her2
Excited to share our latest work on the control of ribosomes that is out today in @Nature. We found that osmotic stress leads to phenotypic diversification of yeast populations through an intron in a ribosomal protein gene. @UniCologne, @ISTAustria. https://t.co/AbGAqCM8Fo 1/n
Happy to share! Paralog genes in cancer. Experimental validation of paralog pairs (RPP25/L, DNAJC15/19, DDX3X/Y and more): Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes https://t.co/meSwaHlnkg
Latest pre-print just out on bioRxiv "Interrogation of cancer gene dependencies reveals novel paralog interactions of autosome and sex chromosome encoded genes" https://t.co/3YMc5hyFPh
This simple #SARSCoV2 saliva test costs $1, gets results in <1 hour, and can be performed anywhere without electricity
https://t.co/hYOuN88bxR by @PrakashLab
Why isn't there US support to get rapid validation of such tests and provided to every household?