Anthony Quartararo

Passionate about biotech and equitable healthcare. Scientist, drug discovery. New Yorker at heart | PhD @ChemistryMIT '20

[BiotechTV @BiotechTV]

𝐂𝐨𝐦𝐩𝐚𝐧𝐲 𝐍𝐞𝐰𝐬: @mmammen recaps the first clinical data Parabilis Medicines reported on its beta-catenin program earlier this month at EMSO and AACR-NCI-EORTC 2025. Plus, degraders for prostate cancer, and more.

Full video: https://t.co/5byCeNi1GY

[drug hunter @drughunter_com]

Zolucatetide, A Modified Peptide Polymacrocycle from Parabilis is the First β-catenin/TCF4 PPI Inhibitor to Reach the Clinic | https://t.co/KkIYjV5nAM

Brian White of Parabilis Medicines presented the discovery story of zolucatetide (FOG-001), a β-catenin/TCF4 interaction inhibitor currently in a Ph. 1/2 trial for advanced solid tumors, at the ACS Fall 2025 meeting.

The starting point for this stapled peptide was discovered using the company’s Helicon™ platform for identifying hyperstabilized α-helical peptides (stay tuned for Drug Hunter’s upcoming modality brief on stapled peptides). Zolucatetide incorporates multiple backbone cyclizations to enforce helicity, limit solvent-exposed amide hydrogen atoms, and enable cytosolic exposure.

This case study will examine the challenges and opportunities that exist in modulating the Wnt/β-catenin pathway and how Parabilis employed their platform to generate the hit compound that led to the first selective inhibitor of the β-catenin/CFT4 PPI to enter human trials.

Read it on Drug Hunter: https://t.co/KkIYjV5nAM

[BioPharma Dive @BioPharmaDive]

FogPharma, Artbio join forces to design a different radiopharma drug https://t.co/ffSmwlp4Se by @NedPagliarulo

[STAT @statnews]

Oncology startup FogPharma just closed a $145 million Series E round, the company confirmed, reaching a late stage of financing that few biotechs meet. https://t.co/97aMLxiXDa

[Nature Biotechnology @NatureBiotech]

Tearing up the traditional biotech playbook https://t.co/XGMEzRvJfH

[Anthony Quartararo @aquart28]

A question I've always been fascinated by is: how can you access totally new chemical space and mine it with high throughput? How can you discover something new from nothing? In that regard, @RosslerSimon and @NathalieGrob put on a clinic
https://t.co/XjeJM7hQ8v

[Simon Rössler @RosslerSimon]

In a collaboration between @BuchwildGroup & @PenteluteLab, we developed peptide-encoded libraries (PELs) as a new platform for small molecule drug discovery. This work with @NathalieGrob is now out in @ScienceMagazine https://t.co/2twVVY5QSL #ScienceResearch @ChemistryMIT

[Anthony Quartararo @aquart28]

Amazing work! Congrats!

[Kiessling Group @KiesslingGroup]

Our work with Hung Lab & @PenteluteLab is out now! Congrats to @azsaebi, @JosephSBrown7, our own @vicmarando & the whole team. The longest peptide synthesized in a single shot sequence had similar biological activity to native proteins against Pseudomonas: https://t.co/urae7HdDRv

[Buffalo Bills @BuffaloBills]

An update we were all hoping for. ❤️�An update we were all hoping for. ❤️�An update we were all hoping for. ❤️�An update we were all hoping for. ❤️💙

[Jordan Schultz @Schultz_Report]

Damar Hamlin is a truly wonderful and special person. He’s made an enormous impact on his community, long before he made the NFL — as you’ll see in the video below. Please pray for Damar and his family. 🙏

[Dan Nomura @DanNomura]

Excited to present our @biorxivpreprint on chemical rational design of molecular glue degraders through a covalent handle targeting RNF126! Congrats to @EthanToriki & @JPapatzimas who led work w/@NovartisScience! & thanks to @TheMarkFdn ! https://t.co/vh5ULa3stk

[Anthony Quartararo @aquart28]

👀 https://t.co/6CjoabqrgN

[Anthony Quartararo @aquart28]

Oh my peptide! @RosslerSimon @NathalieGrob with some amazing work here. Can't wait to see where this leads! @PenteluteLab @BuchwildGroup @ChemistryMIT

[Simon Rössler @RosslerSimon]

Abiotic peptides with high chemical stability can be used to encode the synthesis of small molecules, affording peptide-encoded libraries (PELs) as a new drug discovery platform! @NathalieGrob & my work in @BuchwildGroup & @PenteluteLab now on @ChemRxiv https://t.co/vr0I6IkFTl

[Anthony Quartararo @aquart28]

Excited to represent FogPharma today at the @MIT career fair! Come out and hear about how we are using cutting edge screening technology and AI to tackle historically #undruggable targets #BetaCatenin #UniversalDruggability #DeepLearning #DirectedEvolution #MultiplexedHTS

[Anthony Quartararo @aquart28]

@PomplunSeb @NWONieuws @mm_a_t_a Congrats!

[NEJM @NEJM]

The just-announced U.S. Supreme Court decision in Dobbs v. Jackson Women’s Health Organization represents a stunning reversal of precedent that inserts government into the personal lives and health care of Americans. https://t.co/yB5WRMlXso

[Ruben Gallego @RubenGallego]

Please just stop.. unless you are willing to break the filibuster to actually pass sensible gun control measures you might as well just say “thoughts and prayers”

[Anthony Quartararo @aquart28]

I will never, ever, for the life of me, understand.

[CSPAN @cspan]

Senator Chris Murphy (@ChrisMurphyCT): "The 14 kids dead in an elementary school in Texas right now. What are we doing? What are we doing? Just days after a shooter walked into a grocery store to gun down African American patrons we have another Sandy Hook on our hands."

[Alex Cagan @ATJCagan]

Incredibly excited to share our paper ‘Somatic mutation rates scale with lifespan across mammals’ now published @nature.
https://t.co/a68IkkTt33
An illustrated & updated tweetorial… [1/24]

[Anthony Quartararo @aquart28]

Wow!

[Synthesis Workshop @MatthewHorwitz1]

What a creative and beautiful paper on @ChemRxiv on "Molecular Sonification" (turning molecules into music)!

DOI: 10.26434/chemrxiv-2022-g7xkl

https://t.co/LJoLGJUxHl