Our new paper is out in @NatureNano
We describe a non-viral gene delivery platform that delivers mRNA precisely to damaged cartilage in osteoarthritis and self-regulates targeting and expression as disease severity increases.
https://t.co/s906T7KI5L
https://t.co/XsvSgss32B
Just out in Nature yesterday, SARS-COv-2 infection can awaken sleeping cancer cells! My concern mounts with increasing evidence that COVID is a cancer inducing virus. Viral clearance is more important than ever, especially in those with LONG-COVID.
https://t.co/kml0zXPIMA
Respiratory infections like flu & COVID remain a serious global challenge. Thanks to @FastCompany for spotlighting the science of transmission & the latest advances, including our work at @Akita__Bio & @ProfiNasalSpray. Together, we’re shaping the future of health! #innovation #StayHealthy
A NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is >99.9% effective & contains no drugs 1/
@phorthbeing@danaparish Profi’s BKC level is below the established safe limit for nasal use and lower than widely-used products like Flonase. Learn more here: https://t.co/VBFSDTIVGN
@phorthbeing@danaparish One serving of ice cream contains as much Polysorbate 80 as you would be exposed to by using Profi every day for over five years.
@phorthbeing@danaparish This is driven by the ingredient pectin (and likely enhanced nasal retention time). Pectin neutralized 99.99% of influenza A in vitro, whereas carrageenan neutralized only 90%.
@phorthbeing@danaparish In a lethal Influenza A mouse model, a single pre-exposure dose of PCANS resulted in a greater than 99.99% reduction in lung viral titers and offered 100% survival. Carrageenan demonstrated only 70% survival after multiple doses.
🔥 New, promising data on Profi Nasal Spray (aka PCANS) as prophylaxis for respiratory viruses:
“The researchers developed the formulation and studied its ability to capture respiratory droplets in a 3D-printed replica of a human nose. They showed that when sprayed in the nasal cavity replica, PCANS captured twice as many droplets as mucus alone.
“PCANS forms a gel, increasing its mechanical strength by a hundred times, forming a solid barrier,” said primary author John Joseph, PhD, a former postdoctoral fellow at Brigham and Women’s Hospital. “It blocked and neutralized almost 100% of all viruses and bacteria we tested, including Influenza, SARS-CoV-2, RSV, adenovirus, K Pneumonia and more.”
Experiments in mice showed that a single dose of the PCANS nasal spray could effectively block infection from an influenza virus (PR8) at 25 times the lethal dose. Virus levels in the lungs were reduced by >99.99%, and the inflammatory cells and cytokines in the lungs of PCANS-treated animals were normal.”
$HIMS stock is popping 10%+ after hours after the company announced it is increasing its revenue and profit expectations for the year.
let's break down the report👇👇