András N. Spaan

[András N. Spaan @aspaan1]

4/4 @UMCUtrecht @UniUtrecht @KNVM_online @ESIDsociety @ESCMID @EU_Commission

https://t.co/HYEUFIO4c6

[András N. Spaan @aspaan1]

3/4 Curiosity-driven fundamental research of host-pathogen interactions: a molecular compass to combat infectious diseases. A million thanks for the trust and support – by former mentors, peers, trainees, and the @ERC_Research .

[András N. Spaan @aspaan1]

2/4 Why are most group A streptococcal infections benign, but suffer some otherwise healthy people from a devastating infection with this pathogen? #StrepA #InfectiousDiseases #InbornErrorsofImmunity #TeamScience

[András N. Spaan @aspaan1]

1/4 Above and beyond honored being awarded this European Research Council (ERC) Starting Grant to study the human genetic and immunological determinants of invasive group A streptococcal infections.

[European Research Council (ERC) @ERC_Research]

📣 The latest ERC Starting Grant competition results are out! 📣

494 bright minds awarded €780 million to fund research ideas at the frontiers of science.

Find out who, where & why 👉 https://t.co/L6PimhW50v

🇪🇺 #EUfunded #FrontierResearch #ERCStG @HorizonEU @EUScienceInnov

[András N. Spaan @aspaan1]

9/ @BenedicteNeven, @IsabelleMeyts, @RikSchrijvers, @anne_puel, @BustamanteJaci1, @TorresVJ_Lab, @LabListon, @LaurentAbel4, @Boisson_Bebo and others not yet on Twitter! @RockefellerUniv @UMCU_Intl @UMCUtrecht

[András N. Spaan @aspaan1]

8/ Thank you to coauthors, namely @casanova_lab, @ALNeehus, @frapaport, @Keenan__Lacey, @davidhum8, @MelanieMigaud, @Tatianakochetk1, @HeesterbeekDani, @AshleyDuMontPhD, @SolenneChardon1, @TimourBaslan, @zhangpeng1202, @ryangrui, @BogunovicLab, @StanLyonnet, @ldnotar, @ErdalSag…

[András N. Spaan @aspaan1]

7/ OTULIN haploinsufficiency is the first defect of non-hematopoietic cell-intrinsic immunity to a bacterial infection in humans in vivo. Multiple examples have been previously documented for immunity to viruses (https://t.co/rgUy8lh5SR).

[András N. Spaan @aspaan1]

6/ Naturally elicited antibodies against alpha-toxin can compensate for OTULIN haploinsufficiency, reminiscent of LTA-specific Abs in patients with TIRAP deficiency (https://t.co/YNHXsBrrLp), and explain in part incomplete clinical penetrance.

[András N. Spaan @aspaan1]

5/ Most patients with cri-du-chat syndrome, also known as 5p- syndrome, lack OTULIN, explaining their infections (https://t.co/3CSZ29fBUR). A rare inborn error of immunity helps understanding a more common chromosomal anomaly.

[András N. Spaan @aspaan1]

4/ OTULIN haploinsufficiency is related to but different from autosomal recessive OTULIN deficiency (https://t.co/D4hyxuMWm8), which is a purely auto-inflammatory condition (https://t.co/MlTMXpVUlr).

[András N. Spaan @aspaan1]

3/ The clinical hallmark of OTULIN haploinsufficiency is necrosis of the skin and/or lungs, typically triggered by infections with #Staphylococcus aureus.

[András N. Spaan @aspaan1]

2/ We discovered OTULIN haploinsufficiency via a genome-wide approach in a cohort of patients with unexplained, life-threatening staphylococcal disease – the findings are relevant in vivo.

[András N. Spaan @aspaan1]

1/ Today in @ScienceMagazine, we show that human #OTULIN #haploinsufficiency impairs non-leukocytic cell-intrinsic immunity to the #staphylococcal alpha-toxin. https://t.co/eha0xHOlXE