Boaz Barak

Neurobiologist with special interest in how neuron-glia interaction modulates myelination in neurodevelopmental disorders

[Boaz Barak @BarakBoaz]

@ThoraKaradottir @GoCasteloBranco @Nature Incredible work! Thanks for these findings!

[Thora Karadottir Lab @ThoraKaradottir]

What happens to the brain after focal myelin loss? Our new paper, published today in @Nature tries to answer this question: https://t.co/dCM1kcPd5N
Details in the 🧵 (1/8)

[Boaz Barak @BarakBoaz]

@GoldbergLab מצטער לקרוא ג׳וש היקר! שולח ניחומים וחיבוקים. אם היא גידלה איש מדהים כמוך אין לי ספק שהיא היתה אישה מדהימה ואצילית. שלא תדעו עוד צער.

[Klaus-Armin Nave @KlausNave]

The oligodendroglial map of the brain https://t.co/FE2ltdWWDH

[Boaz Barak @BarakBoaz]

New in Science from the Lyons lab: Myelin sheaths can swell in response to damage, but don't always degenerate. A potential therapeutic window to halt demyelination?

https://t.co/H0NcftjTyy #Neuroscience #Myelin

[Giuseppe Testa @gtesta72]

Thrilled to share our latest paper, now out as cover story!
📄Paper: High resolution multi-scale profiling of embryonic germ cell-like cell derivation reveals pluripotent state transitions in humans: Stem Cell Reports https://t.co/r0O3VdbYFW /1

[R. Douglas Fields @rdouglasfields1]

Ocular dominance and spike-time dependent plasticity have an implicit assumption that conduction velocity is fixed. Our new study on myelin plasticity invalidates that.
https://t.co/bYIgLPpffz

[ShorterLab @ShorterLab]

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy: https://t.co/GDtpGMkr22

[Neuron @NeuroCellPress]

Online now: Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry https://t.co/Ot4bZRhTcK

[Boaz Barak @BarakBoaz]

@SagivShifman Wow!! Amazing work, @SagivShifman ! Congrats

[Boaz Barak @BarakBoaz]

@GiuliaPoggi86 Congrats @GiuliaPoggi86. Looks great and on my reading list!

[Klaus-Armin Nave @KlausNave]

A remarkable cellular mechanism how microglia participate in the turnover of aging myelin. Jump to the hypothesized model in Fig. 7. https://t.co/jximYshv8s

[StandWithUs @StandWithUs]

Scientists from Tel Aviv University, working in collaboration with the Weizmann Institute of Science, Hebrew University of Jerusalem, and the Max Planck Institute in Germany, have uncovered a groundbreaking biological mechanism that could transform how Alzheimer’s disease and Multiple Sclerosis (MS) are treated.

The researchers identified that a protein called Tfii-i inhibits myelin production (myelin is a fatty substance that insulates neurons and enables fast, efficient communication). By reducing Tfii-i levels in specific cells of lab mice, scientists were able to increase myelin growth, leading to thicker myelin sheaths, faster neural signaling, and even improved coordination and mobility.

Once again, Israeli innovation is pushing the boundaries of science, bringing hope to patients around the world.
@TelAvivUni @WeizmannScience @HebrewU

[Sagol School of Neuroscience @of_sagol]

תקווה חדשה למחלות נוירולוגיות!
תגלית ישראלית עשויה לשקם תאי עצב שנפגעו ממחלות מוח.
פריצת דרך מחקרית עשויה להוביל לטיפולים חדשים במחלות נוירולוגיות: נחשף מנגנון ביולוגי להגברת ייצור מיאלין במוח.
@BarakBoaz

[GonçaloCasteloBranco @GoCasteloBranco]

Our latest collaboration with @RongFan8, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @karolinskainst and @Di_0579 in Rong's lab! Check it out @Nature

https://t.co/W6ihT5tMQY

[Boaz Barak @BarakBoaz]

@ArielIonescu @inna_slutsky @NatureNeuro @LabPerlson What an amazing story and achievement! Congrats @ArielIonescu and @LabPerlson

[Boaz Barak @BarakBoaz]

🙌 Huge thanks to @GiladLevy7 who led the entire study, and the amazing team who made this possible: @MarcoAsaf @inna_slutsky @PelesMCB @werner_hauke @AssafLab @nshomron

@Tel_Aviv_Uni @TelAvivUni @of_sagol @AFTAU @CFTAU #myelin #oligodendrocytes #whitematter

[Boaz Barak @BarakBoaz]

🚀 Our new paper is out in Nature Communications!

We uncovered a mechanistic switch to boost myelination: deleting Gtf2i in myelinating glia enhances Sox10/Mbp activity → thicker myelin, faster conduction, improved motor coordination.

🔗 https://t.co/ZSzns8K2vB

[Boaz Barak @BarakBoaz]

This discovery could inspire new treatments for many neurological conditions affected by myelination dysfunction.

Here’s what it looks like 👇

[Boaz Barak @BarakBoaz]

@Tel_Aviv_Uni הישג אדיר כל הכבוד אורי! @BenDavidLab