New review! @skleinstein and I cover how B cell lineage trees are built using single cell VDJ data, and how they can be used to study B cell evolution, differentiation, and temporal dynamics during immune responses. Free access link: https://t.co/Dwyj1Ls7A7
The latest from our lab @BarouchLab on mucosal vaccination for respiratory pathogens! Out in @Nature today, we show that boosting by intratracheal route enhances mucosal immune responses and provides complete protection from infection! Go give it a read!
https://t.co/JUrtzDDmrD
Live attenuated influenza vaccine induces disparate Ab responses in the mucosa and blood associated with distinct immune responses early post-inoculation, w/ IL-33 limiting peripheral Ab but enabling mucosal IgA @p_openshaw@InThwaiteImmune
https://t.co/Mk36Ou7crN
Out today @NatureComms, we show the distinction of mucosal and systemic antibody responses to live attenuated flu vaccine (LAIV) in humans and distinct mucosal immune mechanisms behind these separate humoral outcomes 📢🧵https://t.co/ju0WOBfWHw
Three protective Abs that cross-react with neuraminidases from seasonal H3N2 strains spanning multiple decades with implications for developing broadly protective influenza vaccines @wchnicholas@ImmunityCP
https://t.co/W23U2fK1aQ
Thanks to immigrants, the US won 75% of Nobel prizes in 2023. Without them, we only would have won 25%.
High skilled immigration is a policy lever for more innovation unlike anything else. Oh and its free.
🚨New paper alert!
Following on from our recent work showing that Bmi-1 is an important regulator of plasma cells, our new study provides evidence that BMI-1 may also be a viable therapeutic target to deplete plasma cells in autoimmunity: https://t.co/dLd5CKyysF
Last week we had a 75th bday symposium for my mentor Rafi Ahmed. His closing words should be a motto for all we do:
"This is my message to you: whatever you do, being a good human being is the most important"