Acacia Dishman, MD PhD

Transitional Year Resident at Aurora in Milwaukee. Starting at Harvard Radiation Oncology Residency Program 7/1/2024.

[Acacia Dishman, MD PhD @cacidish]

@sokrypton @Lauren_L_Porter Nice hack! The other fold ("Ltn40") forms in low salt, higher temperature (e.g. 40C, hence the "40") conditions, but I am not sure if that can be used as a hack for this purpose

[Acacia Dishman, MD PhD @cacidish]

@Lauren_L_Porter A cool looking prediction! ... But likely not what's going on biologically :) This is a great example of how much more we can learn going forward

[Florian Praetorius @FloPraetorius]

@proleu Once again, thanks to Maxx and @StollPatro, @adam_broerman, Cullen, @ArvindSPillai1, Abbas, @cacidish and @bvolkie, @DaveJuergens, @JustasDauparas, the IPD cores, and everyone at @UWproteindesign!

Go team #crispyshifty

[Florian Praetorius @FloPraetorius]

@proleu and I are excited to see our work on multistate design of hinge proteins finally published as a peer-reviewed paper
https://t.co/4T2eHk8g77

[Trends in Biochemical Sciences @TrendsBiochem]

In the August issue, read Reviews on:

#metamorphic protein folding (@cacidish)
activating and silencing #enhancers
#tudordomain interactions (@NeugebauerKarla)
#phosphoproteinphosphatases (@KettenbachLab)
and #adhesionGPRCs

https://t.co/jrlEBK8BPR

[Trends in Biochemical Sciences @TrendsBiochem]

📢 Online now - the Review "#Metamorphicprotein folding as evolutionary adaptation" from @cacidish and Brian Volkman
@MedicalCollege.

#foldswitching #ancestralsequencereconstruction #conformationaldynamics #proteinfitness

Read it here 👉 https://t.co/jFYqrAU4Qg

[Brigham and Women’s Radiation Oncology @BrighamRadOnc]

@HarvardRadOnc @_AkshatPatel_ @abrarc @JzStack @palakp97 @cacidish
🎉 Congratulations! Can't wait to welcome you in person!

[Harvard Radiation Oncology Program @HarvardRadOnc]

We are SO excited to announce the results of the 2023 Match and to introduce you to our HROP class of 2028!! #Match2023 #MatchDay #radonc #MedTwitter

[Florian Praetorius @FloPraetorius]

Shoutout to @RavennaBrewing and @Reubensbrews who with their collaborative beer #CrispyShifty unknowingly and retroactively inspired us to design proteins that are both crispy (fully structured and well defined in both states) and shifty (readily switching between both states)

[Florian Praetorius @FloPraetorius]

@proleu and I proudly present our preprint on designed hinge proteins that switch between two fully structured conformations:
https://t.co/av2To4V9VL

[Florian Praetorius @FloPraetorius]

It really was a team effort! Thanks to Maxx and @StollPatrol, @adam_broerman, Cullen, @ArvindSPillai1, Abbas, @cacidish and @bvolkie, @DaveJuergens,@JustasDauparas, the IPD cores, and everyone at @UWproteindesign!

Go team #CrispyShifty!

[Institute for Protein Design @UWproteindesign]

We are mourning the loss of Dan Tawfik, a brilliant researcher and longtime friend of the institute. His scientific accomplishments will endure, as will his kindness, generosity, and humor. Dan made the world a better place.

[Trends in Biochemical Sciences @TrendsBiochem]

The primary @ScienceMagazine article is titled "Evolution of fold switching in a metamorphic protein" by @cacidish in the lab of Brian Volkman and their colleagues: https://t.co/SM1XxFgLw4

[Viviane Callier 柯蔚文 @vcallier]

my latest for Quanta - a story about metamorphic proteins that switch rapidly and reversibly between two folds. A superpower for cells. But basically double trouble for protein designers 😅.

@cacidish @UWproteindesign @MedicalCollege

[Acacia Dishman, MD PhD @cacidish]

So excited to share our work on the evolution of metamorphic proteins!

https://t.co/GKqs2kKRjJ

[Medical College of Wisconsin @MedicalCollege]

A shapeshifting immune system protein called XCL1 evolved from a single-shape ancestor hundreds of millions of years ago. Now, researchers at MCW discovered the molecular basis for how this happened. Learn more: https://t.co/HCMwleUwR9