Charlotte Bl

[Charlotte Bl @chablessing]

I'm beyond excited to share my latest paper with you, in which we identify the chromatin remodeler ALC1 as a regulator of PARP2 trapping. Just published yesterday @MolecularCell! 1/6
https://t.co/NvGt3j6F5B

[Charlotte Bl @chablessing]

@sheeradar @luijsterburglab @NatureComms @LadurnerAndreas @haicovanattikum @hanneslans Thank you very much for your and your team's input! The slot blot assays really strengthened the set of DNA repair defects that we were observing.

[Charlotte Bl @chablessing]

@haicovanattikum @HombreRRo @luijsterburglab @NatureComms @LadurnerAndreas @hanneslans @sheeradar Thank you so much for Magdalena's and your contribution! I'm still excited that the microlaser irradiation experiments actually worked and we finally found a way on how to measure chromatin opening at UV-C sites!

[Charlotte Bl @chablessing]

@HombreRRo @luijsterburglab @NatureComms @LadurnerAndreas @haicovanattikum @hanneslans @sheeradar Thank you so much for your help! I really liked the mass spec insights!

[Charlotte Bl @chablessing]

Very happy to share that another chapter of my Ph.D. and a fun collaboration is published! Thanks to all contributors!

[Martijn Luijsterburg @luijsterburglab]

Our story on how XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair is now online in @NatureComms.

Close collaboration with the labs of @LadurnerAndreas, @haicovanattikum, @hanneslans, @sheeradar

https://t.co/d6r5vkgMMD

[Charlotte Bl @chablessing]

@claudiag013 So nice to finally see this out! Thanks for your great help!!

[Charlotte Bl @chablessing]

@isaac_fianu @ScienceMagazine @CramerLab Congrats, Isaac! Looks really cool!

[Charlotte Bl @chablessing]

@clautinaschmidt @maxplanckpress @mpibpc Congrats! Such great news! 😊

[Charlotte Bl @chablessing]

@DangH_Nguyen @luijsterburglab @StaplesLab @LadurnerAndreas @sheeradar @joachimgoedhart Thanks - I can definitely recommend it! Exactly, I normalized each value to the median of the respective replicate before plotting them.

[Charlotte Bl @chablessing]

@luijsterburglab @StaplesLab @LadurnerAndreas @sheeradar @joachimgoedhart Yes, exactly! This has worked nicely with Prism 9 as well. I just formatted the median from each biological replicate as a coloured dot.

[InPharma2021 @InPharma2021]

A great big thank you to our Session 1 speakers, Drs. Iris Gonzalez Leal, Carla Winter, & Giuliana Möller!
We learned a lot about R&D career opportunities in the Pharma/Biotech industry! #inPharma2021 #pharma #biotech #Science

[Charlotte Bl @chablessing]

Have a look at this new research coming from our department! So excited for @VanessaLuzak and @siegel_lab.

[Vanessa Luzak @VanessaLuzak]

My very first paper got published today! 🎊🍾💃 Using Hi-C, we found an intriguing role of dynamic DNA contacts in parasite immune evasion. Special thanks to @JoanaRCF and @siegel_lab with all members! You are a great scientific family. https://t.co/EyuHbey3oI

[Charlotte Bl @chablessing]

@GraemeHewitt2 I can imagine, I would have been exactly the same! And I can only give the congrats back! Such a great paper - you basically answer all open questions, that we discussed in our paper, two weeks later! 🙂

[Charlotte Bl @chablessing]

@luijsterburglab This looks very cool indeed!

[Charlotte Bl @chablessing]

@MichaelNADbio @MolecularCell Thanks so much, very happy to hear! I'm curious to see where the PARP field is bringing us in a few years, so many exciting advancements happening at the moment.

[Charlotte Bl @chablessing]

I'm beyond excited to share my latest paper with you, in which we identify the chromatin remodeler ALC1 as a regulator of PARP2 trapping. Just published yesterday @MolecularCell! 1/6
https://t.co/NvGt3j6F5B

[Charlotte Bl @chablessing]

@GeneOnlineNews @MolecularCell Thank you very much!

[Charlotte Bl @chablessing]

@SatejaParadkar @MolecularCell Thanks so much for the feedback! It's wonderful to hear that you enjoyed the story as much as I do.

[Charlotte Bl @chablessing]

@luijsterburglab @MolecularCell Thanks a lot, Martijn! Probably at least a hundred times. In the end, Andreas was even a second faster in spotting it! I'm also excited for the next paper and am really happy that we are doing this collaboration together.

[Charlotte Bl @chablessing]

@durocher1 @MolecularCell Thank you so much, very happy to hear this! Back in 2018, we were really happy that ALC1 showed up as a high-significance hit in your olaparib screen. This was a nice validation for the early data we had back then.

[Charlotte Bl @chablessing]

This was a fantastic team effort @LMU_Muenchen. Thanks to @claudiag013 @LadurnerAndreas and everyone else involved. An especially enlightened PARP2 even made its way into the Christmas decoration of our institute! 6/6

[Charlotte Bl @chablessing]

Strikingly, the deletion and inhibition of ALC1 result in PARP2 trapping, severe hypersensitivity to PARP inhibitors and to BRCA deficiency. This does not only put PARP2 trapping into focus for cancer treatments, but also identifies ALC1 as a new potential cancer drug target.5/6