Check out our latest paper from the Stein lab (@mpi_bpc, @VedranVasic ) where we provide molecular insights into the endoplasmic reticulum ubiquitin ligase Doa10!
Using a fully reconstituted system, we show that it is a membrane protein retrotranslocase.
https://t.co/v4x8vcTIh4
❗️pH matters❗️
Excited to share that my first co-corresponding author paper is out in @Dev_Cell!
🔬We've uncovered an evolutionarily conserved mechanism regulating amyloid formation and disassembly via pH-sensing regions in yeast & humans. Check it out😊
https://t.co/2rVF784ai1
Have you ever wondered how ribosome abundance is controlled in changing environments?
I am excited to share our latest preprint on the ribosome dormancy factor Stm1 and its role in ribosome biogenesis. Here is a thread:
https://t.co/UHvVwDlsgJ
⚠️ONE WEEK left to register for the thrilling summer course Autophagy in Neurodegeneration, Neuroinflammation and Immunity. Great chance to explore these amazing fields! Need more info? Contact the course coordinator [email protected] or visit the link https://t.co/PTp5vsCNXl
Ever wonder why cells of the same type tend to have a pretty uniform size? Check out our new paper out in @MolecularCell today to find out why too big can be a bad thing in terms of genome homeostasis and proliferative potential. 🧵 (1/9)
https://t.co/OHRq0ls7P9
The final version of mitosis specific CUL4B function is now published @embojournal.
In addition, we show CUL4B depletion impairs brain development in beautiful forebrain organoids.
Congrats to all the authors and collaborators 🎉
https://t.co/bDnwXtT4Ez
@ETH_DBIOL@ETH_en
3 wonderful days at #IBCRetreat2023@ETH_DBIOL
Great line of invited keynote speakers @_taktas_@Dey_Gautam and @BerndPulverer, talks and posters from PhDs & postdocs, scientific discussions and team building.
Thanks to the organizers and all participants for successful event.
The first transmembrane domain of most membrane proteins serves as both a targeting signal and a membrane anchor. We show that such signal-anchors are inserted in the correct orientation at the ER membrane through sequential triage by the EMC insertase and Sec61 channel.