Roberto Chica Lab

Our research group at the University of Ottawa specializes in protein engineering and computational protein design.
#proteinengineering #proteindesign

[Roberto Chica Lab @Chica_lab]

Happy to announce our latest publication on #enzymedesign, in collaboration with @MThompsonLab! Check it out in @J_A_C_S:

Design of Efficient Artificial Enzymes Using Crystallographically Enhanced Conformational Sampling https://t.co/GsxCAHH9Yo

[Tokuriki lab @tokuriki_lab]

I am very excited to share that our paper led by @erdogananisan, @PouriaDasmeh, @AdrianSerohijos is out @natcomms. It touches key dynamics to understand protein evolution"Neutral Drift" and "Phenotypic Variation" during enzyme/protein evolution.

https://t.co/EOJTGv8MNc

[Sergey Ovchinnikov @sokrypton]

Come see the scientists that should've shared the Nobel Prize for "Computational Protein Design", speak:
https://t.co/vQMNKW1xMP

[Roberto Chica Lab @Chica_lab]

@UCSF @fraser_lab @ARPA_H @QBI_UCSF Congrats @fraser_lab and colleagues! Looking forward to hearing more about this exciting research.

[Oxford Journals @OxfordJournals]

We are recruiting: @ProtEngDesSel is looking for an Editor-in-Chief to lead the journal into the future! If you’re a leader in protein engineering with a strong vision for the field, we want to hear from you.

View more details and apply: https://t.co/wqYwxOvFhQ
#JournalEditor

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

[Roberto Chica Lab @Chica_lab]

For more information, check out the nice editorial written by @ferruz_noelia and @_amelie_rocks:

https://t.co/67gIQGBPBl

[Roberto Chica Lab @Chica_lab]

Happy to announce the special article collection on computational methods for #ProteinDesign, which I edited for @ProtEngDesSel.

[PEDS: Protein Engineering, Design & Selection @ProtEngDesSel]

@ProtEngDesSel is excited to share its latest article collection on "Computational Methods for #ProteinDesign". Free to read until Sept. 30, 2024: https://t.co/0s5z4UK17Z

[Kortemme Lab @KortemmeLab]

We’re thrilled to share our new pre-print exploring how we can design and control dynamic proteins! (1/6) https://t.co/w7sRsdJV9y

[Roberto Chica Lab @Chica_lab]

@MartinPacesa @Nature @CasperGoverde @GoldbachNico @befcorreia Very cool, congrats!

[Martin Pacesa @MartinPacesa]

Today in @Nature we present the results of our exploration of the soluble protein universe and the design of functional soluble membrane proteins with @CasperGoverde @GoldbachNico @befcorreia 1/6

https://t.co/Dakeh8Hyw7

[Simon Duerr @simonduerr]

We investigated AlphaFold3 against RoseTTAfold-AllAtom and a new variant of Metal3D for prediction of metal-protein complexes. Tl;dr AlphaFold3 is as good as specialized tools on metal ion prediction. RFAA not so much.

Some interesting findings in below thread: 1/

[Diego del Alamo @DdelAlamo]

An interesting nugget in the latest paper from @MoAlQuraishi lab: AFDB models are less designable in ways that suggest inaccuracies at the local level but not global level https://t.co/9sX2IVjhyr

[Kresten Lindorff-Larsen @LindorffLarsen]

This is a complex discussion that I am hoping will continue well beyond this letter. We need to find standards that work in an increasingly complex landscape of research and publishing, and that balances diverse interests.

We need to find solutions that enable science to ...

[Roberto Chica Lab @Chica_lab]

Abstract submission deadline is April 30th.

More info here:
https://t.co/fvBOmD4WET

[Stephan Hammer @Stephan_Hammer]

Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.

Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group

🙏RETWEET (We want to recruit internationally)

https://t.co/xol9YRph9u

[J. Am. Chem. Soc. @J_A_C_S]

Design of Efficient Artificial Enzymes Using Crystallographically Enhanced Conformational Sampling | Journal of the American Chemical Society @ucmerced @uOttawa @Chica_lab @uOttawaScience #Artificial #Enzyme #Crystallographic #Conformational #Sampling https://t.co/PbUqZUKCSn

[Protein Engineering and Directed Evolution Papers @and_protein]

Design of Efficient Artificial Enzymes Using Crystallographically Enhanced Conformational Sampling https://t.co/dU7QX8NwIJ