David Adams

Multiple Sclerosis | Hiking | Health & Fitness | Nutrition | Exercise | Calisthenics | Fasting | Isaiah 40:31

[David Adams @david_adams22]

Fasting...can even alter the course of some diseases, from cancer & multiple sclerosis to diabetes and Alzheimer’s

https://t.co/JIQIW2xWvl

[Dr. Brandon Beaber @Brandon_Beaber]

Common symptoms of multiple sclerosis. From the LA times https://t.co/jJSbUbxo2J

[David Adams @david_adams22]

@SamOlbur As someone said, he’s addition by subtraction when he goes on the DL, and subtraction by addition when he rejoins the rotation

[Manuel Ruiz @manruipa]

🔴⚠️‼️Have you heard a flood of news stories about Epstein-Barr virus and multiple sclerosis over the last few days?

Pay attention, because many headlines are telling the story incorrectly. Or, at the very least, they are telling you only part of it.

The news is not simply that “the mononucleosis virus activates certain lymphocytes.”

Nor have we only just discovered that Epstein-Barr virus is associated with multiple sclerosis. This had been suspected for decades and became extraordinarily well supported in 2022.

The real news is that we are beginning to understand how a virus that remains inside our B cells for life could keep the immune circuit that eventually attacks the nervous system switched on.

And that completely changes the therapeutic question:

Why do we continue limiting ourselves to suppressing the immune system without also trying to control the virus that is probably fueling the process?
(1/14)🧵👇🏻

[David Adams @david_adams22]

Fermented Garlic-Dill Carrots
2 cups distilled water
2 Tbsp unrefined sea salt
1.5 lb carrots peeled
3 garlic cloves peeled & pressed
Dill Fresh or dried, chopped

Ginger-Turmeric Carrots
Swap the dill for a 2-inch knob of fresh sliced ginger and a tsp of ground turmeric per jar

[TheHealthyRD @HeidiHmoretti]

Fermented carrots = one of the easiest gut-health upgrades you can make at home.

New research shows food-derived microbes from fermented vegetables can make up ~3% of your adult gut microbiota — a meaningful contribution from diet alone.

Plus fermentation actually increases beta-carotene, lutein & anthocyanins in carrots.

5 flavor variations + the science behind why it works → https://t.co/QYm77U5Cy4

#TheHealthyRD #TestNotGuess #GutHealth

[David Adams @david_adams22]

@RussellShaw_MLS What do you have as ‘optimal’ for Cystatin C?

[David Adams @david_adams22]

Potential MS treatments targeting Epstein-Barr Virus

https://t.co/TOOzn82fdU

[Dr. Brandon Beaber @Brandon_Beaber]

Potential multiple sclerosis treatments targeting Epstein-Barr virus. One of the authors is a colleague of mine, Dr. Hannah Zhao-Fleming https://t.co/EXedwt7BWc

[Eric Topol @EricTopol]

Deep B cell depletion is rebooting the immune system, the basis for a potential curative approach to a long list of autoimmune diseases
https://t.co/yIJCikSNe5

[David Adams @david_adams22]

@GuruAnaerobic @RegenaisanceMan Looks like cassava or yuca (South American shrub). Has cyanide in raw form - must be cooked.

[David Adams @david_adams22]

@RogerSeheult Similar phenomenon with MS which is much more prevalent further from equator. Sun/vit D likely play a roll. As well as the gut - probably the ileum microbiome which impacts immune system. In sub-Sahara Africa EBV causes Burkitt’s lymphoma

[David Adams @david_adams22]

@Brady_H Are the micro intervals just an easy way to work in some brief intensity without impairing recovery for tomorrow’s workout?

[David Adams @david_adams22]

@Mark_Sisson This is what PE in schools should be (or used to be before it became a joke blowoff class or disappeared entirely)

[Michael McNeil @MichaelEMcNeil]

Caltech's terrific video series (+ book(s)) on classical mechanics The Mechanical Universe—hosted by physicist David L. Goodstein, divided in 54 half-hour episodes—is very worthwhile as a whole, but given Artemis II happening now, see especially episode 24: “Navigating in Space”.

https://t.co/gfrygriznQ

[Andrew D. Huberman, Ph.D. @hubermanlab]

I was going to send this to @Brady_H but I think many people will enjoy this biography of legendary Oregon track and field coach and Nike cofounder Bill Bowerman. Unique teaching tactics (that would never ever fly today!) https://t.co/XbCUh5jESl

[Multiple Sclerosis News Today @MSNewsToday]

People with MS who carry the APOE4 gene variant show greater signs of nerve damage and cognitive decline than those who don't, a study found. https://t.co/mllIc1tq0L #MultipleSclerosis #MSTreatment #MSResearch #MSNews

[David Adams @david_adams22]

~10% of people never fully clear EBV from their bloodstream. Maybe worthwhile to find out if you’re one of them. Need a viral-load PCR for EBV DNA test (~$250-$400 from Ulta Labs, Quest, LabCorp, etc)

https://t.co/GlLfKMKYVe

https://t.co/r8tTNWhh1Q

[Norn Group @NornGroup]

Multiple lines of evidence are converging on the idea that viruses you picked up decades ago might quietly be driving age-related diseases.

We've known for a few years that EBV raises MS risk 32-fold, and that molecular mimicry between an EBV protein and nerve insulation likely triggers brain autoimmunity. What remained unclear was why some people persistently carry EBV and others don't.

A new paper in @Nature from the @RyanDhindsa (whose lab has been supported by @impetusgrants) and @CalebLareau labs answers that at population scale. They mined ~735,000 human genomes for traces of Epstein-Barr virus, using reads of viral genomes that existing pipelines were throwing out as junk, and found that ~10% of people carry detectable EBV DNA in blood.

Carrying persistent EBV is associated with variable antigen processing, and the broader genetic architecture of viral persistence shares a component with lupus, rheumatoid arthritis, and type 1 diabetes.

Meanwhile, a separate line of very recent evidence is also pointing in that direction. The shingles vaccine, targeting another persistent herpesvirus, is showing ~20% dementia risk reduction in quasi-randomized studies which has been replicated across multiple countries.

There seems to be more at the intersection of immunity and age-related disease than we initially thought.

[David Adams @david_adams22]

How Epstein-Barr virus triggers MS

• For current MS patients, EBV vax won’t help
• Better option might be to “tolerize” the immune system so it no longer responds to GlialCAM
• 2 promising technologies:
- Reverse vaccine using DNA plasmids
- RNA technology (from BioNTech)

[Dr. Gabriel Pardo @DocforMS]

Another 🧩 of the #MS -EBV puzzle. This work on how it happens adds to last week’s paper on causality. The story is coming together. @drbarrysinger @AaronBosterMD @GavinGiovannoni @Brandon_Beaber https://t.co/QtlNSGgtFE

[David Adams @david_adams22]

The findings also emphasize preventing EBV infection or reactivation, especially in genetically at-risk populations, as a strategy to reduce MS incidence.

[NASA @NASA]

These pictures of the Pillars of Creation were taken 19 years apart by different telescopes, with each image capturing a unique perspective.

On the left, @NASAHubble shows more thick dust. On the right, @NASAWebb peers through the dust to show more stars. Which is your favorite?

[Eric Topol @EricTopol]

What drives immunosenescence—the degradation of function our immune system with aging that increases the risk of age-related diseases?
Today @SciImmunology the B cells are identified as the bad actors because they induce T cell (CD4) dysfunction and inflammaging (work in experimental model). When B cells are eliminated, healthspan improves.
https://t.co/N4CiK7SszD

[Eric Topol @EricTopol]

We just learned about some secrets of the Epstein-Barr virus (not files)!
New, ingenious method to quantify EBV load from its DNA sequence in the blood, which correlates with different diseases. Also specific variants of EBVDNA had clinical relevance. Load (EBVemia) not linked to multiple sclerosis. New @Nature @uk_biobank @AllofUsResearch
https://t.co/2PZh8ruUdf
https://t.co/QFx0AvaywH