@EuroCilia2022 #cilia2022 impressive talk by Samuel Lacey from @GaiaPigino's lab on the structure of anterograde IFT trains https://t.co/EblQzNl92M
Also check out this poster article from the Pigino lab in JCS for an overview on intraflagellar transport https://t.co/CRFsosY9Mi
I am excited beyond words that this is now out: https://t.co/hC5rDy8aRw.
After so many years of hard work, we can finally answer maaany questions about IFT… 🎉
Thanks Sam @stanuel02 Lacey, @_Helen_Foster_, the cryo-EM facility @humantechnopole, and notably also #AlphaFold2! ❤️
Our study with @CentrioleLab @GaiaPigino on the Chlamydomonas ciliary base is online @ScienceMagazine: https://t.co/sWH2YFsMER
We combined #CryoET🔬 with #UExM🔬 to:
1⃣ Reveal the structure of the transition zone (movie👇)
2⃣ Observe the assembly of IFT trains (next tweet)
1/🧵
🔬❗️ New preprint: CSPP stabilizes growing microtubule ends and damaged lattices from the luminal side. A few key results in a 🧵 1/6
https://t.co/vI8uY6Kzrj
We are thrilled to share our latest work of the atomic structure of the central apparatus (CA) within the famous "9+2" architecture of motile #cilia.
https://t.co/wvJpcfOLE5
🚨 Cilia CRISPR-Cas9 Tech Job 🚨
Join the Pigino Lab and become our Chlamy CRISPR expert. We have an exciting new method for direct gene knock-ins you can start with! 🧪🧫🧬#cilia#Chlamy#IFT#CRISPR#job
Click here 👉 https://t.co/WinOGPlJzX
Please either apply or retweet! 😉
NEW BIORXV is out:
We studied the molecular architecture of the C. elegans #centriole by combining #UExM with #ElectronMicroscopy.
We mapped the known centriolar components onto their ultrastructural #EM features.
https://t.co/h3zvtS9TiE
Check out our latest work on @biorxivpreprint! We solved the structure of dynein-dynactin on microtubules to high resolution. This helps us understand how the machinery moves and shows how *two* cargo adaptors can be recruited. Work by @sami_chaaban. https://t.co/QEuTb3736n