Dhruvit Joshi

Tech. AI. Bio. Energy. Startups. 🧬🤖⚡️

[Tim Ferriss @tferriss]

Most information is time-consuming, negative, irrelevant to your goals, and outside of your influence.

[Akshay Kothari @akothari]

Models come and go
Your data compounds

So, own the context
Lease the intelligence.

[Naval @naval]

Existence itself is a miracle - the rest is science.

There is no single meaning to existence - if there were, we’d be slaves to it.

Within existence, there are rules of logic and science. If it was magic, the world would be un-navigable.

Truly the best of all possible worlds.

[Noah Schochet @noah_schochet]

Today, we’re announcing that we’ve raised $115 million in funding, including a $100M Series A led by @kleinerperkins.

America has lost the ability to build, and we’re here to restore it. My co-founder, @NoahMcGuinn, and I left our jobs at @SpaceX , where we worked on programs including Starship, Starshield, and @Starlink, to build a company that will solve construction’s greatest challenges.

Infrastructure is the foundation of civilization, and construction is the precursor to innovation. If America wants to build a brighter future for the next generation, we have to make it faster, cheaper, and safer to build.

That’s where @TerraFirma_Inc comes in. We’re a new type of company, a robotic construction company that builds the full technology stack needed to deliver an order-of-magnitude improvement in one of the world’s oldest, largest, most important, but least efficient industries.

We are building technology that expands what’s possible in construction on Earth, and then we'll use that same technology to build megastructures and colonies on the Moon and Mars.

We’ve made tremendous progress over the past year, growing the company more than 10x in the last 12 months. We are performing projects across the world. By the end of October 2026, we are on track to operate 3 of the top 3 largest robotic construction fleets in the world, each on a different continent, bringing unprecedented speed, scale, and efficiency to some of the world’s most complex critical infrastructure projects.

This funding will allow us to step on the gas and scale our manufacturing, software, operations, and construction deployments, including work on massive commercial and government contracts.

We’re building the future of construction right here in Austin, Texas, and scaling it globally. If you want to be part of the team changing the world, now and on Mars, join us.

Our Series A was led by Kleiner Perkins, with participation from Bain Capital Ventures, Glade Brook Capital Partners, BANNER VC, Saga Ventures, Trust Ventures, Definition, PEAK6, Magnetar Capital, and Ravelin Capital. Huge thanks to all of our angel investors, friends, and family who have helped and supported us throughout this journey.

Apply here: https://t.co/BmXHSGJQQk

[Ben Lang @benln]

https://t.co/dfEjtC0I62

[Alexis Ohanian 🗽 @alexisohanian]

There are three things you cannot buy. Fitness: You have to keep fit, whether you’re rich or not. Diet: You cannot pay someone to be on a diet for you. I think that diet is the biggest sacrifice in my life. Then, looking after your soul. No one can possibly treat your soul but you yourself. This is something you can do through culture and philosophy.

[Dhruvit Joshi @dhruvitjoshi]

The new era of science 🧬🧑‍🔬👏

[NVIDIA Healthcare @NVIDIAHealth]

From machine learning algorithms to AI agents.
#BionemoEraTour

[Dhruvit Joshi @dhruvitjoshi]

While everyone is busy debating monthly market share numbers, @OlaElectric is quietly building the one thing that matters most in the EV industry:

🔋 Batteries.

Today, Ola's indigenous 46100 LFP cell received BIS certification.

Most investors will scroll past this.

They shouldn't.

Why this matters:

✅ Designed and developed in India
✅ Lower-cost LFP chemistry
✅ Applicable across EVs AND energy storage
✅ Another step toward a fully integrated energy ecosystem

For years, India has assembled batteries.

Very few companies are attempting to master cell chemistry, manufacturing, software, vehicles, and energy storage under one roof.

That's the real story.

The market is focused on scooter deliveries.

Ola is focused on owning the entire energy stack.

If Ola succeeds with its battery roadmap, future investors may look back at today's scooter business the same way Amazon investors look back at online book sales.

A starting point.

Not the destination.

[Ola Electric @OlaElectric]

First Indian company to receive BIS certification for an indigenously developed 46100 LFP Cell. 🔋

Certified and qualified across IS 16893, UN 38.3, and BIS standards. Our 4680 Bharat Cells are already clocking millions of km on Indian roads - and now we expand further.
NMC to LFP. Mobility to energy storage. All 46-series. All made in India. 🇮🇳

[Dhruvit Joshi @dhruvitjoshi]

One of the most fascinating founder pivots I've seen in years:

@DavidSHolz went from building futuristic human-computer interfaces at Leap Motion to creating one of the world's most popular AI image generators, Midjourney.

Now he's taking on healthcare. 🚀

His latest project?

A full-body scanner that aims to map the human body in ~60 seconds using advanced ultrasound technology, wrapped inside what he calls a "medical spa" experience, complete with saunas, cold plunges, and wellness facilities.

At first glance, it sounds crazy.

Then you realize he's pursuing the same idea he's always pursued:

Making the invisible visible.

First imagination.
Now biology.

But here's what makes this story even more interesting:

This isn't just an AI company entering healthcare.

Midjourney partnered with @ButterflyNetInc, a pioneer of portable ultrasound technology.

The current scanner prototype incorporates 40 Butterfly Ultrasound-on-Chip modules, with hundreds of thousands of sensors capturing data simultaneously and over 2 petaflops of compute processing the results. The scanner combines cutting-edge hardware, physics, and compute to create detailed 3D maps of the human body.

The problem with today's imaging world:

- MRI scans are expensive and often difficult to access.
- Appointments can take weeks.
- CT scans involve radiation.
- Most people get only occasional snapshots of what's happening inside their bodies.

The result?

Healthcare is often reactive rather than preventive.

Midjourney's vision is different:

Imagine if understanding your body became as routine as tracking your steps or checking your heart rate.

- Step into a scanner.
- Get a 3D map of your body in about a minute.
- Grab a sauna afterward.

Sounds more like @Apple Store meets @Equinox meets @MayoClinic than traditional healthcare.

Hot take:

The real breakthrough isn't the scanner.

It's the convergence of three worlds:

- Butterfly's ultrasound-on-chip technology
- AI-era compute infrastructure
- A future where billions of body scans create one of the largest health datasets ever assembled

Most people see a wellness spa.

I see the potential foundation for the next generation of preventive medicine.

@DavidSHolz helped millions visualize their imaginations with Midjourney.

Now he's betting he can help billions visualize their biology.

That's either completely insane...

...or one of the most important healthcare ideas of the decade.

[Midjourney @midjourney]

Announcing a new division of Midjourney called "Midjourney Medical"

[Sahil Bloom @SahilBloom]

Major cheat code for life: Become difficult to rush. The world will pressure you to rush into everything. Rushed decisions. Rushed conversations. Rushed relationships. Rushed timelines. There's immense power in rejecting that trend. Slow down. Create space to think clearly.

[Dhruvit Joshi @dhruvitjoshi]

@midjourney Inspiring!🙌🏻👏🏻

[Midjourney @midjourney]

A technical dive inside our new "Midjourney Scanner"

[Dhruvit Joshi @dhruvitjoshi]

Read More: https://t.co/Mrl98LkQKE

[Dhruvit Joshi @dhruvitjoshi]

🔬🚨 One of the biggest breakthroughs in microscopy in years just came out of @UCBerkeley and @biohub .

For decades, cryo-EM has revolutionized biology by allowing scientists to see molecular structures at near-atomic resolution.

But there was one major limitation:

More than 90% of human proteins are simply too small to be imaged clearly with today's cryo-EM systems.

In other words, much of the cell's molecular machinery has remained effectively invisible.

UC Berkeley and Biohub have now demonstrated a revolutionary "laser phase plate" that dramatically boosts image contrast, allowing researchers to visualize previously hidden proteins and molecular interactions inside cells.

Why this matters:

🧬 The average human protein is currently too small to study with conventional cryo-EM.

💊 Many of those proteins are potential disease mechanisms and drug targets.

🔍 This breakthrough could unlock an unprecedented view of how molecular machines interact inside living cells at near-atomic detail.

The potential implications are enormous:

• Better understanding of cancer biology
• New drug targets previously hidden from view
• Faster drug discovery
• Mapping cellular processes in unprecedented detail
• A future "Google Maps" of the molecular machinery of life

🔥 Hot take:

AI may help us understand biology.

But first, we need better ways to SEE biology.

The next decade of biotech breakthroughs may be driven as much by advances in imaging as advances in AI.

Today, UC Berkeley and Biohub may have opened a new window into the cell itself. 🚀

[NewLimit @newlimit]

Each year, we share a public update on our progress @newlimit from our lab in South San Francisco.

This year, we announced:

1. 2X increase in discovery rates with AI systems
2. New program focused on endothelial cells
3. 0 -> 1 medicines headed to the clinic

Full event video below

[Dhruvit Joshi @dhruvitjoshi]

Link - https://t.co/WesFDwCx8D

[Dhruvit Joshi @dhruvitjoshi]

$LLY just raised the bar in the obesity race. Again.

Its next-gen triple agonist #Retatrutide delivered:

✅ Up to 28.3% weight loss (~70 lbs average)
✅ Significant A1C reductions
✅ Major improvements in knee osteoarthritis pain
✅ Meaningful reductions in obstructive sleep apnea severity
What's becoming clear:
The obesity market is no longer just about losing weight.
The winners will be drugs that improve the entire metabolic ecosystem — obesity, diabetes, cardiovascular risk, sleep apnea, inflammation, and quality of life.

Retatrutide is starting to look less like "another GLP-1" and more like a potential platform therapy for chronic metabolic disease.

🔥 Hot take:

The biggest healthcare disruption of the next decade may not be AI.

It may be obesity drugs that dramatically reduce the incidence of diabetes, heart disease, sleep apnea, joint replacements, and healthcare spending at scale.

No surprise $LLY continues to pull further ahead in the obesity arms race.

$LLY #Healthcare #Biotech #Obesity #GLP1 #Retatrutide #Medicine #Investing

[Nithin Kamath @Nithin0dha]

I find it odd when people turn businessmen into role models, and this seems to have become more common in the last 5-odd years. It's the same with idolising movie stars and sports stars. None of it should happen, really. 😀

When people come to me for advice, my first reaction is: What makes you think I'm qualified?

Just because I've gotten lucky in business, does that make me qualified to advise you on your career, your life choices, or anything apart from how to get lucky? 😀

There are startup founders, especially people working in the social sector, whom I meet through @RainmatterOrg, and I think they are far smarter and more capable of giving advice than I am.

If you still pick a role model, pick someone for a trait worth admiring in real life, not because of what they project to the outside world.

[Brian Armstrong @brian_armstrong]

Aging is arguably the root cause of most major diseases (loss of function in our cells). Four years ago, we made a bet that aging was treatable, and NewLimit was born.

NewLimit now has a prototype drug that reverses the age of some human cells (restores function they had when they were younger), and a clinical trial scheduled for next year (with more drug candidates in the pipeline).

Grateful to Founders Fund, Thrive, Greenoaks, and the rest of the investors for this latest round. @jacobkimmel and the team are just getting started.

[Eric Topol @EricTopol]

Just published @NEJM
Marked and durable reduction of LDL cholesterol with one shot PCSK9 gene base editing @skathire https://t.co/3fU9EjatjH