Seth Parker

Assistant Professor at the University of British Columbia and BC Children's Hospital Research Institute. He/him.

[Seth Parker @DrSethP]

Our paper on alpha-ketoglutarate (aKG) metabolism is out today in @NatureComms https://t.co/TvjqRykOsY! Short summary to follow soon.

[Anirban Maitra @Aiims1742]

One theme from #AACRPan25
There is tremendous excitement about KRAS trials in #PancreaticCancer but I am BEGGING reviewers & editors to understand that we are still PRIOR to that inflection point where paired biopsy samples from patients are widely available to investigators.

[Anirban Maitra @Aiims1742]

The first example of how the impressive scRNA seq data set in #PancreaticCancer (collated by @NinaSteele17) can be leveraged for hypothesis generation & testing is now published in @CCR_AACR.
Sita Kugel @fredhutch demonstrates that HMGA2 is a reliable marker of the basal subtype of pancreatic cancer, and rigorously validates it in a large number of tissues at the protein level (including in one of the largest collection of cases of African American background).
The combination of HMGA2 & GATA6 - interrogating the basal & classical cell types, respectively, provides prognostic discrimination over any one marker.

[Daniel J Drucker @DanielJDrucker]

Recurrent #pregnancy loss. New candidates from #genetics @NatureComms https://t.co/NcxAaBzFUV

[FrezzaLab @FrezzaLab]

"A diverse proteome is present and enzymatically active in metabolite extracts"

important paper for the metabolomics community
https://t.co/xq071p2v3O

[Cosimo Commisso @Cosimo_Commisso]

We have an amazing line up for #PancWest2024. Happy to host all these amazing pancreatic cancer researchers at @SBPCancerCenter. Looking forward to tomorrow!

[Harmit S. Malik @HarmitMalik]

That amazing paper you spent years on? That amazing breakthrough you had? Very likely you built this following the work of others (very few exceptions), just as others will build off yours. Science is a continuum. Want to leave a lasting legacy in science? Be generous & be kind.

[Denis Wirtz @deniswirtz]

We have developed a repertoire of >30K velocity receptors that enhance CAR T cell infiltration into solid tumors.

We tested one of these for pancreatic tumors (bottom) that showed far better infiltration than standard mesothelin CAR T cells (top).

Here: https://t.co/bfAty2caj2

[Peter Mullen @PeteMullen]

Check out our new review by @StevePilley and Edgar! It was a great process working with guest editors @DrSethP and Thekla Cordes https://t.co/y04XDrxmAa

[Siavash Kurdistani @VashKurdistani]

Update on histone H3 copper reductase activity: Purified native yeast nucleosomes also act as enzymes & optimal activity depends on Zn. This could explain known Zn, Cu interplay & raises the possibility that DNA may be involved in electron conductance. 1/3
https://t.co/QeSb4chw3F

[Evan Lien @eclien]

Excited to share the first review - and the first official "product" - from the Lien lab! 🥳We discuss how dietary factors can influence tumor progression by modulating the balance between saturated and unsaturated fatty acids. Check it out!👇 https://t.co/Lf1kiubpiH

[Seth Parker @DrSethP]

Thank you also to @NSERC_CRSNG for supporting Jessica (CGS-M) and Keeley (PGS-D) this year! I'm lucky to have such talented people in my lab :)

[Seth Parker @DrSethP]

Very proud of @_zaynabb_ for receiving the #VanierCanada award from @CIHR_IRSC this year!

[UBC Biochemistry & Molecular Biology @UBCbiochemistry]

🌟Meet Abisola Kehinde: Vanier Scholarship recipient 🌟

Get inspired by Abisola’s dedication to her research and her passion to contributing to the development of science and health. Read her story here: https://t.co/elVFE14Key

#UBC #Graduate #Scholarship

[UBC Biochemistry & Molecular Biology @UBCbiochemistry]

🌟Meet Abisola Kehinde: Vanier Scholarship recipient 🌟

Get inspired by Abisola’s dedication to her research and her passion to contributing to the development of science and health. Read her story here: https://t.co/elVFE14Key

#UBC #Graduate #Scholarship

[Seth Parker @DrSethP]

I'm thrilled to be a part of such an amazing team! Thank you to the @tfri_research and #lottehecthfnd for your wonderful support.

[Lum Lab @lum_lab]

Our team consists of world experts in MSI @goodlettlab1 @uvic @UVicResearch @UVicScience @Kyle_D_Duncan @VIUniversity, hypoxia #sdedhar, stress responses #psorensen #rrottapel @pmcancercentre, amino acid metabolism @DrSethP @BCCHresearch, and immunometabolism @lum_lab. 4/5 -JJL

[Lum Lab @lum_lab]

Absolutely thrilled to announce that our team will be funded by the @tfri_research & #lottehecthfnd New Frontiers PPG - Together, we want to use spatial metabolomics to tackle how tumor metabolism creates a barrier to immunotherapy. 1/5 -JJL

[David B Sauer @DavidBSauer]

Our @RESOLUTE_IMI protocols for cloning, expressing, and purifying human SLCs are coming out in @JoVEJournal!

Work of MANY brilliant scientists, including @sagaraturi @AndreeaScacioc @TomasPascoa @Anna_Liiiiiiii @katharina_duerr @AlvaroIngles1

https://t.co/leTj8I4xnB

[Seth Parker @DrSethP]

@Dr_Perreault @grantsfacilitat @DrStephCraig @uofg @rkleingeltink I tried to email you, but my email keeps bouncing. Do you have another email address?

[Russell Jones @DrRGJonesLab]

Happy to share our new paper out in @ImmunityCP on ketolysis as a metabolic driver of CD8 T cell responses. Great work spearheaded by @KawaZbozowa and @jlongo92 and fun collaboration with @ketonemics. @VAIMetabolism @VAInstitute https://t.co/v1rBDlMdpJ

[Muir Lab @Muir_Lab]

Review from @japizsaab on new tools to study how the tumor microenvironment (TME) reprograms tumor resident cells: https://t.co/19cNpdlWAc TLDR: TME was a black box but new tools (including interstitial fluid analysis) tell us what is in the TME and how it interacts with cells.