One theme from #AACRPan25
There is tremendous excitement about KRAS trials in #PancreaticCancer but I am BEGGING reviewers & editors to understand that we are still PRIOR to that inflection point where paired biopsy samples from patients are widely available to investigators.
The first example of how the impressive scRNA seq data set in #PancreaticCancer (collated by @NinaSteele17) can be leveraged for hypothesis generation & testing is now published in @CCR_AACR.
Sita Kugel @fredhutch demonstrates that HMGA2 is a reliable marker of the basal subtype of pancreatic cancer, and rigorously validates it in a large number of tissues at the protein level (including in one of the largest collection of cases of African American background).
The combination of HMGA2 & GATA6 - interrogating the basal & classical cell types, respectively, provides prognostic discrimination over any one marker.
We have an amazing line up for #PancWest2024. Happy to host all these amazing pancreatic cancer researchers at @SBPCancerCenter. Looking forward to tomorrow!
That amazing paper you spent years on? That amazing breakthrough you had? Very likely you built this following the work of others (very few exceptions), just as others will build off yours. Science is a continuum. Want to leave a lasting legacy in science? Be generous & be kind.
We have developed a repertoire of >30K velocity receptors that enhance CAR T cell infiltration into solid tumors.
We tested one of these for pancreatic tumors (bottom) that showed far better infiltration than standard mesothelin CAR T cells (top).
Here: https://t.co/bfAty2caj2
Check out our new review by @StevePilley and Edgar! It was a great process working with guest editors @DrSethP and Thekla Cordes https://t.co/y04XDrxmAa
Update on histone H3 copper reductase activity: Purified native yeast nucleosomes also act as enzymes & optimal activity depends on Zn. This could explain known Zn, Cu interplay & raises the possibility that DNA may be involved in electron conductance. 1/3
https://t.co/QeSb4chw3F
Excited to share the first review - and the first official "product" - from the Lien lab! 🥳We discuss how dietary factors can influence tumor progression by modulating the balance between saturated and unsaturated fatty acids. Check it out!👇 https://t.co/Lf1kiubpiH
🌟Meet Abisola Kehinde: Vanier Scholarship recipient 🌟
Get inspired by Abisola’s dedication to her research and her passion to contributing to the development of science and health. Read her story here: https://t.co/elVFE14Key
#UBC#Graduate#Scholarship
🌟Meet Abisola Kehinde: Vanier Scholarship recipient 🌟
Get inspired by Abisola’s dedication to her research and her passion to contributing to the development of science and health. Read her story here: https://t.co/elVFE14Key
#UBC#Graduate#Scholarship
Absolutely thrilled to announce that our team will be funded by the @tfri_research & #lottehecthfnd New Frontiers PPG - Together, we want to use spatial metabolomics to tackle how tumor metabolism creates a barrier to immunotherapy. 1/5 -JJL
Happy to share our new paper out in @ImmunityCP on ketolysis as a metabolic driver of CD8 T cell responses. Great work spearheaded by @KawaZbozowa and @jlongo92 and fun collaboration with @ketonemics. @VAIMetabolism@VAInstitute https://t.co/v1rBDlMdpJ
Review from @japizsaab on new tools to study how the tumor microenvironment (TME) reprograms tumor resident cells: https://t.co/19cNpdlWAc TLDR: TME was a black box but new tools (including interstitial fluid analysis) tell us what is in the TME and how it interacts with cells.