Esteban Arellano

Positive feedback loops and error correction | Applied Stats @uoft

[Jensen Huang @JensenHuang]

@ChaseLochmiller @OpenAI GPT-6 Astra, trained on ~100K+ NVIDIA Grace Blackwell NVLink72. From ChatGPT to o1 to Astra in 4 years.

AGI has arrived. Congratulations @OpenAI team.

400K GPUs coming online next.

[Moderna @moderna_tx]

Moderna and @Merck today announced positive topline results from the Phase 3 INTerpath-001 trial evaluating adjuvant treatment with intismeran autogene, a novel investigational mRNA-based individualized neoantigen therapy jointly developed by Merck and Moderna, in combination with KEYTRUDA® (pembrolizumab), Merck's anti-PD-1 therapy, in patients with completely resected Stage IIB-IV melanoma.
Read more:

[Noam Brown @polynoamial]

An internal version of Astra, @OpenAI’s next major model family, solved 10 major open problems in mathematics, quantum complexity, and theoretical computer science.

We believe it will be a major step for scientific reasoning. https://t.co/iP6cyheZ7i

[Esteban Arellano @exarellanom]

@realAkashAnand Video skills

[Matt Krisiloff @mattkrisiloff]

I’m so excited to share this update on @Conception –

We’ve generated the first early human eggs derived from stem cells.

This is a big deal -- the potential to redefine fertility is real.

[Patrick Collison @patrickc]

New project: https://t.co/0mvpzkysHb.

More: https://t.co/G5af6WXdTL.

[Esteban Arellano @exarellanom]

@sama @ChatGPTapp hey codex

[Esteban Arellano @exarellanom]

@MichLieben ads

[Esteban Arellano @exarellanom]

@HeyGen Hyperframes

[HeyGen @HeyGen]

We built our launch video in Claude Code using HyperFrames.

Now it's yours.

Open source, agent-native framework. HTML to MP4.

$ npx skills add heygen-com/hyperframes

RT + Comment "HyperFrames" to get the full source code of this launch video (must follow)

[Elon Musk @elonmusk]

Engineering is real magic

[Tesla @Tesla]

TERAFAB: the next step to becoming a galactic civilization

Together with @SpaceX & @xAI, we're building the largest chip manufacturing facility ever (1TW/year) – combining logic, memory & advanced packaging under one roof.

To harness as much power as possible from the Sun, we need to send 100 million tons of solar capture into space – per year.

This requires massive scale.

– Capability to launch millions of tons of mass into orbit

– Solar-powered AI satellites

– Millions of @Tesla_Optimus robots to help build it out

All of these need chips: 100-200GW of chips for Optimus alone, plus terawatts for solar-powered AI satellites.

That's more than all the chip manufacturers in the world combined can provide today, or even by 2030 (based on projected production growth).

We're building TERAFAB to close the gap between today’s chip production & the future's demand – a future among the stars

https://t.co/tHumlppgMm

[Esteban Arellano @exarellanom]

@thsottiaux the Mac app tends to get laggy after a lot of use

[Esteban Arellano @exarellanom]

@thedeoncardoza @claudeai Playbook

[Esteban Arellano @exarellanom]

@amigafreelance https://t.co/yvSON1SzuL

[Esteban Arellano @exarellanom]

@lennysan https://t.co/yvSON1SzuL

[Esteban Arellano @exarellanom]

@Zephyr_hg STUDIO

[Andrej Karpathy @karpathy]

I've never felt this much behind as a programmer. The profession is being dramatically refactored as the bits contributed by the programmer are increasingly sparse and between. I have a sense that I could be 10X more powerful if I just properly string together what has become available over the last ~year and a failure to claim the boost feels decidedly like skill issue. There's a new programmable layer of abstraction to master (in addition to the usual layers below) involving agents, subagents, their prompts, contexts, memory, modes, permissions, tools, plugins, skills, hooks, MCP, LSP, slash commands, workflows, IDE integrations, and a need to build an all-encompassing mental model for strengths and pitfalls of fundamentally stochastic, fallible, unintelligible and changing entities suddenly intermingled with what used to be good old fashioned engineering. Clearly some powerful alien tool was handed around except it comes with no manual and everyone has to figure out how to hold it and operate it, while the resulting magnitude 9 earthquake is rocking the profession. Roll up your sleeves to not fall behind.