Federico Rossari

MD PhD | Cancer Gene&Cell Therapy @NaldiniLab, Milan | Visiting Scholar, @penn CCI | Medical Oncology fellow @MyUniSR, Milan | Alumnus @ScuolaSantAnna, Pisa

[Federico Rossari @f_rossari]

🧵1/
🚨 Just out in Science Translational Medicine @ScienceTM our latest work @NaldiniLab:
We show how tumor-targeted cytokines can rescue CAR-T function and recruit endogenous T cells to fight glioblastoma, the toughest brain cancer.
🔗https://t.co/dRuvDW6ISN
👇 Here's a thread:

[Andrea Necchi @AndreaNecchi]

n preparation of my #ESMO25 Presidential discussion of RC48-C016 trial (Ph III Disitamab vedotin+Toripalimab vs chemo 1L HER2+ metastatic #urothelialcarcinoma) I would love to hear your opinion on the preferred option for 1L therapy.
Provided EVP is available/reimbursed and a clinical trial testing HER2-ADC+IO vs chemo is available at your site, which option would you choose first: @myESMO @urotoday @brunolarvol @OncLive @OncoAlert @montypal @DrChoueiri @IBCG_BladderCA @BladderCancerUS @WorldBladderCan @PGrivasMDPhD @shilpaonc @UroDocAsh @SpiessPhilippe

[Waggoner Lab @LabWaggoner]

Tumor-targeted cytokine delivery by engineered myeloid cells unlocks CAR T cell efficacy and endogenous T cell responses in glioblastoma @MolTherapy
on
https://t.co/uyT4tdHews @ScienceTM @NaldiniLab

[Molecular Therapy Family of Journals @MolTherapy]

Tumor-targeted cytokine delivery by engineered myeloid cells unlocks CAR T cell efficacy and endogenous T cell responses in glioblastoma https://t.co/YMT2CTC7kH #genetherapy #celltherapy

[Federico Rossari @f_rossari]

Our commentary is out in @MolTherapy!
How targeted cytokines help CAR T cells fight GBM by rewiring the TME & boosting immunity.
Details 👉 https://t.co/7csgjuuZDs

@NaldiniLab
#Immunotherapy #CART #GBM

[Giorgio Orofino @giorgio_orofino]

🚨 Paper Alert 🚨
Truly honored for being part of this super project led by the fantastic @f_rossari out in @ScienceTM ! We showed how reprogramming the #TME via #HSC #engineering may restore #CART cell function also in #GBM !
Kudos to the super team who made this happen 🙌

[Federico Rossari @f_rossari]

🙏

[Renato Ostuni @OstuniLab]

Out in @ScienceTM! The Naldini lab delivers another masterclass of stem/immune cell gene engineering to deliver cytokines in the TME and boost CAR-T cell activity in glioblastoma.
Kudos to @f_rossari @giorgiaalvisi and Nadia Coltella for this important study🔥

[Waggoner Lab @LabWaggoner]

Tumor-targeted cytokine delivery by TAMs establishes a private cross-talk that rescues CAR T cell function and engages host T cells to treat GBM
https://t.co/uyT4tdHMm0
@NaldiniLab @ScienceTM

[John Connolly @John_E_Connolly]

A cross-talk established by tumor-targeted cytokines rescues CAR T cell activity and engages host T cells against glioblastoma in mice | Science Translational Medicine https://t.co/7KqRGs4OCp

[andrea casadei gardini @casadei_gardini]

Excited to share our new study published in JNCI! 🧬
In >500 real-world BTC pts treated with cisplatin, gemcitabine & durvalumab, we found:
✔️ SMAD4 mut = better outcomes
❌ TP53 & TERT mut = worse survival
🔬 A new clinico-molecular score for patients

https://t.co/RS2BSYVEl7

[Federico Rossari @f_rossari]

Huge thanks to all co-authors, including @GiorgiaAlvisi @OttaviaVitaloni @FilippoBirocchi @giorgio_orofino @OstuniLab @Mariosqua
#Glioblastoma #CARTcells #Immunotherapy #TumorMicroenvironment #CancerResearch #OncoTwitter #SciComm

[Federico Rossari @f_rossari]

🧵1/
🚨 Just out in Science Translational Medicine @ScienceTM our latest work @NaldiniLab:
We show how tumor-targeted cytokines can rescue CAR-T function and recruit endogenous T cells to fight glioblastoma, the toughest brain cancer.
🔗https://t.co/dRuvDW6ISN
👇 Here's a thread:

[Federico Rossari @f_rossari]

12/
📌 Bottom line:
Delivering IFN-α and orthogonal IL-2 via tumor-resident TEMs rewires the GBM microenvironment, rescues CAR-T cells, and engages the host immune system.

🔗 Read it here: https://t.co/dRuvDW6ISN
🧠🧬🧪