Alexander Metz

[Alexander Metz @FragMetz]

@tweethue @miss_shivs Are you fucking kidding us?! This is a persistent issues. So get your head out of your ass and do your own trouble shooting instead of asking stupid questions like that.

[Jan Wollenhaupt @Jan_Wollenhaupt]

Proud to represent @HzbMxde at the Fragment-based Down Under Conference 2022 and show our facility for cristallographic fragment screening at @HZB_BESSY and our workflow of growing fragment hits using @biosolveit tools.

#FBDDDU

Great job of hosting by @ARC_CFBD

[Structural Biology @ActaCrystD]

Chia-Ying Huang et al.: Probing ligand binding of endothiapepsin by `temperature-resolved' macromolecular crystallography #FragmentBinding #ProteinPlasticity ... #IUCr https://t.co/hXnNykAwNB

[Manfred S. Weiss @ManfredSWeiss]

Of Problems and Opportunities – How to Treat and How to not Treat Crystallographic Fragment-Screening Data https://t.co/O5Pv0FoxQc

[Ido Ben-Shalom @IdoBenShalom]

Hi @united, why are there NO #vegetarian/#vegan meals on your flights??? @peta

[Alexander Metz @FragMetz]

@dzvng Glückwunsch und alles Gute!

[Jan Wollenhaupt @Jan_Wollenhaupt]

what to do with your crystallographic fragment hits?

our approach now in Acta Cryst D

big team effort by Klebe group @Uni_MR and @HzbMxde
thanks to all involved, you are great people to work with!
@FragMetz @TatjanaBKL @ManfredSWeiss

@iNEXT_Discovery @HZBde @HZB_BESSY

[Frank von Delft @FrankvonDelft]

It's been quite a year...

[Tatjana @TatjanaBKL]

My first first author paper! So happy and excited to see it published in a journal!

[Johannes Karges @Johannes_Karges]

Rational Design of Ru complexes for 1- and 2-Photon Photodynamic Therapy is out in @NatureComms. Very excited to see that some work I started 3.5 years ago and allowed me to work from France to China is published now. @GasserGroup @group_ctm @BlacqueO
https://t.co/s0AKYkTIZt

[Ido Ben-Shalom @IdoBenShalom]

Thanks to the collaborators from Silicon Therapeutics: Zhixiong Lin, Brian Radak, Charles Lin, and Woody Sherman

[COVID Moonshot @covid_moonshot]

Quick reminder: Moonshot's next newsletter with a deep-dive on all the latest results is coming out in a few days. Sign up here if you would like to receive it: https://t.co/QEcMqfcx4y

[Practical_Fragments @PracticalFrag]

More fragment screening with crystals! A round-up with detailed experimental conditions and results for two different libraries against several proteins.
https://t.co/v6xtQJQX1G
@ChemMedChem @Structure_CP @Biomol_MDPI @HZB_BESSY @ManfredSWeiss

[Coffeezilla @coffeebreak_YT]

NEW VIDEO:
In a time when a lot sucks, this is the most inspiring, altruistic project I’ve ever had the fortune of learning about.

It’s called The COVID Moonshot Project, and I want to show you their incredible work, and explain why they need your help.
https://t.co/uFAI46lrjC

[HZB-MXde @HzbMxde]

At present, researchers at the HZB keep their MX beamlines busy with the second campaign of screening compounds against the main protease
MPro of SARS-CoV-2.

[Tristan Croll @CrollTristan]

Oh, wow - looks like they're all out by *nine* residues (Pro 918 is where Pro 927 should be; Leu 907 is where Trp 916 should be). Would *not* have been easy to pick this in the original 6nur, but 7btf is both higher resolution and has slightly more "tail".

[JCIM & JCTC Journals @JCIM_JCTC]

#Protein–Ligand Complex Solvation Thermodynamics: Development, Parameterization, and Testing of #GIST-Based Solvent Functionals
https://t.co/XkCerVVCYy
#Current_issue #Computational_chemistry

[Kai Kupferschmidt @kakape]

My good news contribution for today: Researchers in Denmark are starting to test a promising drug in #covid19 patients, barely a month after research appeared showing the drug could stop the virus in cell culture. Quick thread https://t.co/pji5bA53fK

[Andy Biotech @AndyBiotech]

#COVID19 This is probably the best scientific explainer I have seen on why we should all wear masks against #coronavirus
https://t.co/bCXCA7tgpQ

“We cannot any longer claim that masks ���are not effective”. We cannot allow the perfect to be the enemy of the good.” #Masks4All

[COVID Moonshot @covid_moonshot]

Check out the latest post from @jchodera on his docking results for a re-purposing screen using @foldingathome resources:
https://t.co/hJp1rERmxG

@london_lab @PostEra_AI