filippkramer

founder @unobio

[filippkramer @fvkramer]

The one-person biotech is about more than team size. It's about where the industry is heading.

As biotech becomes more distributed and accessible, deciding what to build, how, and when becomes increasingly important.

Today we're introducing Praxis, our integrated biotech development platform.

From scientific hypotheses and clinical strategy to CRO selection and financing, we're building the infrastructure for a new generation of biotech companies.

We're opening applications for our first 20 companies.

https://t.co/FkHXhLpSfD

[filippkramer @fvkramer]

A great chance for any early, strong technical team to come build in Miami!

[Pascal Unger @PascalUnger]

Anyone can build now. Few dare to aim big enough.

That's why we're launching Southbound W27 by @thelabmiami & @focal_vc today.

Code is now cheap, abundant, and written by machines. What’s scarce is real ambition, intelligence, compute, and distribution.

It's what Southbound is built for: To help the best technical founders think bigger and move faster from day 1.

We're now opening applications to the second cohort of our winter residency.

If you want to:
- Escape the cold
- Work on an absurdly ambitious problem, surrounded by your best technical peers
- Get weekly mentorship by unicorn founders
- Funding on an uncapped MFN SAFE (vs giving up 7%)
- $1M in perks and compute
- and much more

... then join us in Miami from Jan 11 - Apr 11 2027.

Southbound is:
- Limited to 10 spots (teams or solo founders)
- Fully in person in Miami
- 7 days / week in office.

The cohort is small by design: Instead of being a number in a big batch, you get a hand-picked group of your best peers, weekly dinners with unicorn founders, and real time with focal’s GPs.

Rolling admission until all 10 spots are filled / applications close Dec 11.

Apply asap (link in comments!)

@ayalstern | @DanielDarling | @amiine_afia | @wynwoodceo | @SydneyWasi

[Pascal Unger @PascalUnger]

Anyone can build now. Few dare to aim big enough.

That's why we're launching Southbound W27 by @thelabmiami & @focal_vc today.

Code is now cheap, abundant, and written by machines. What’s scarce is real ambition, intelligence, compute, and distribution.

It's what Southbound is built for: To help the best technical founders think bigger and move faster from day 1.

We're now opening applications to the second cohort of our winter residency.

If you want to:
- Escape the cold
- Work on an absurdly ambitious problem, surrounded by your best technical peers
- Get weekly mentorship by unicorn founders
- Funding on an uncapped MFN SAFE (vs giving up 7%)
- $1M in perks and compute
- and much more

... then join us in Miami from Jan 11 - Apr 11 2027.

Southbound is:
- Limited to 10 spots (teams or solo founders)
- Fully in person in Miami
- 7 days / week in office.

The cohort is small by design: Instead of being a number in a big batch, you get a hand-picked group of your best peers, weekly dinners with unicorn founders, and real time with focal’s GPs.

Rolling admission until all 10 spots are filled / applications close Dec 11.

Apply asap (link in comments!)

@ayalstern | @DanielDarling | @amiine_afia | @wynwoodceo | @SydneyWasi

[filippkramer @fvkramer]

@PascalUnger @thelabmiami @focal_vc An exceptional, dense growing Miami tech group!

[Barrett Lyon @BarrettLyon]

Today we’re launching https://t.co/RDkfsVglfw, enabling Agentic Defined Networking for everyone. We raised $38M from @a16z, @AnimoVentures and https://t.co/vbtAvydk57.

Create private networks for you and your AI agents, without a server in the middle. 38M+ threats blocked since December.

Our first private-network call was a freedom call. Now it’s your turn.

[IPO Newsroom @IPONewsroom_]

Anthropic has filed for an IPO, with its prospectus revealing just how fast the company is scaling.

FY25 revenue jumped 1,088% YoY to $4.59B, while compute and infrastructure spending rose 190% to $7.33B.

The company posted an $8.06B operating loss and ended 2025 with $20.28B in cash and short-term investments.

Anthropic’s two largest direct customers accounted for 24% of total revenue combined.

[filippkramer @fvkramer]

LOE pressure causes in crease BD demand for external assets. May shift to later-stage, de-risked, differentiated deals rather than just "less of everything".

[filippkramer @fvkramer]

@QuiverQuant positive EV

[Bio Protocol @BioProtocol]

Fund, learn, use.

Bio is building rails to modernize how biomedical science reaches the real world:

• Bio Protocol: fund research, build communities, go lab → market
• BioAgents: AI scientists surface what works, for whom and why
• Biofy: commerce layer turns research into real, shippable products

Digital rails for accelerated scientific production.

From lab to shelf exponentially cheaper and faster.

Ship science in 2026.

[filippkramer @fvkramer]

@thdxr invent claude code -> entire developer community shows how to use it

[filippkramer @fvkramer]

@biogerontology It would be cool to have dynamic diagrams where you could adjust weights of a signaling molecule and see the downstream weighted response

[filippkramer @fvkramer]

@jrkelly Single person biotech companies without ever touching a lab

[filippkramer @fvkramer]

@SteveWiesnerSMB Similarly why hiring sales people from top brands doesn't always work - the brand's marketing did most of the work.

Big corp promotions hide so many factors

[filippkramer @fvkramer]

@naval slop vibes

[filippkramer @fvkramer]

@amritwt 😂

[filippkramer @fvkramer]

@hthieblot The better engineer before LLMs, the better after. The opposite is true as well. The worse before the worse after. Widens the normal distribution and flattens the curve

[Pascal Unger @PascalUnger]

𝐋𝐚𝐮𝐧𝐜𝐡 𝐀𝐥𝐞𝐫𝐭: Winter 2026 Residency for Technical Founders at Inception!

This winter, we’re bringing together 10 hardcore AI builders for an exclusive residency in Miami with all the firepower of a top accelerator without the heavy dilution!

This is the most talent-dense, high-velocity, carefully curated launchpad for technical AI founders outside SF to start a venture scale company - AND you get to escape the harsh winter while you ship!

The 3+ month residency - hosted in partnership with The LAB Miami - is hyper selective (10 startups only), highly intense (6+ days / week in office) and fully in person (Miami relocation required / costs offset).

Plus you get mentored by unicorn founders including Digital Ocean ($4B NYSE), Mural ($2B), Papa ($1B), vLex (acquired for $1B), Quicknode ($1B), Spotnana ($1B), and many more.

The best part: There’s no “too early” - apply with nothing more than your drive to build a venture scale company, your idea, and the ability to ship exceptional products at breakneck speed.

Applications just opened - apply at https://t.co/mESQH4gjb9 to start in Jan 2026!

𝐏𝐒: 𝐓𝐨 𝐫𝐞𝐟𝐞𝐫 𝐚 𝐛𝐫𝐢𝐥𝐥𝐢𝐚𝐧𝐭 𝐛𝐮𝐢𝐥𝐝𝐞𝐫, 𝐭𝐚𝐠 𝐭𝐡𝐞𝐦 𝐛𝐞𝐥𝐨𝐰 𝐚𝐧𝐝 𝐰𝐞’𝐥𝐥 𝐩𝐫𝐢𝐨𝐫𝐢𝐭𝐢𝐳𝐞 𝐭𝐡𝐞𝐢𝐫 𝐚𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧.

@focal_vc

[Mike Krieger @mikeyk]

We’re launching our Claude for Life Sciences initiative today, including new bioinformatics Skills, and new MCPs from @benchling, @BioRender, PubMed, @WileyGlobal, @Sagebio, @10xGenomics and more:

https://t.co/qONB8arod2

[Nathan S. Cheng thinks you should work on aging. @realNathanCheng]

🧵1/ LBF7 Spain is happening and we're doing something kinda wild:

-We’re gathering the smartest people who want to SOLVE AGING
-going to a longevity resort in the Spanish mountains
-to learn, discuss and ACTUALLY BUILD stuff for 7 days straight

Here’s what we’re cooking 👇

[filippkramer @fvkramer]

@AWSSupport As of 30 minutes ago our alerts showed failed connections. Nothing else changed on our end